DegronMD - Q9HBD1(RC3H2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R886M	TCGA-05-4382	LUAD	TCGA	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation rewiring degron network	0.1389
p.R886M	DO24900	LUAD	ICGC	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation rewiring degron network	0.1389
p.A907V	TCGA-06-5858	GBM	TCGA	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation rewiring degron network	0.0833
p.A907V	TCGA-21-1080	LUSC	TCGA	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation rewiring degron network	0.0833
p.A907V	TCGA-FI-A2D5	UCEC	TCGA	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation rewiring degron network	0.0833
p.A907V	DO228935	COCA	ICGC	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation rewiring degron network	0.0833
p.A907V	DO10892	GBM	ICGC	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation rewiring degron network	0.0833
p.A907V	DO26502	LUSC	ICGC	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation rewiring degron network	0.0833
p.A907V	DO41331	UCEC	ICGC	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation rewiring degron network	0.0833
p.A907V	ACH-001369	Ovarian Cancer	CCLE	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation rewiring degron network	0.0833
p.I893R	TCGA-95-7567	LUAD	TCGA	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation altering degron motif	0.8102
p.I893R	DO25564	LUAD	ICGC	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation altering degron motif	0.8102
p.P895S	TCGA-AJ-A3EK	UCEC	TCGA	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation altering degron motif	0.6752
p.P895S	TCGA-EE-A2GB	SKCM	TCGA	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation altering degron motif	0.6752
p.P895S	TCGA-EE-A3AE	SKCM	TCGA	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation altering degron motif	0.6752
p.P895S	DO222683	MELA	ICGC	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation altering degron motif	0.6752
p.P895S	DO37802	SKCM	ICGC	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation altering degron motif	0.6752
p.P895S	DO37417	SKCM	ICGC	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation altering degron motif	0.6752
p.P895S	DO41584	UCEC	ICGC	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation altering degron motif	0.6752
p.Q707R	TCGA-AX-A05Z	UCEC	TCGA	PPMY	ITCH	703:706	Mutation rewiring degron network	0.3056
p.Q707R	DO40884	UCEC	ICGC	PPMY	ITCH	703:706	Mutation rewiring degron network	0.3056
p.R699C	TCGA-AX-A1C9	UCEC	TCGA	PPMY	ITCH	703:706	Mutation rewiring degron network	0.2222
p.R699C	DO43098	UCEC	ICGC	PPMY	ITCH	703:706	Mutation rewiring degron network	0.2222
p.R699C	SIDM00680	Colorectal Carcinoma	GDSC	PPMY	ITCH	703:706	Mutation rewiring degron network	0.2222
p.R699C	ACH-000957	Colon/Colorectal Cancer	CCLE	PPMY	ITCH	703:706	Mutation rewiring degron network	0.2222
p.R699C	LS-180	large intestine	COSMIC	PPMY	ITCH	703:706	Mutation rewiring degron network	0.2222
p.P892S	TCGA-B5-A3FC	UCEC	TCGA	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation rewiring degron network	0.3056
p.P892S	TCGA-EE-A3JD	SKCM	TCGA	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation rewiring degron network	0.3056
p.P892S	DO50299	SKCM	ICGC	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation rewiring degron network	0.3056
p.P892S	DO41871	UCEC	ICGC	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation rewiring degron network	0.3056
p.Y706C	TCGA-D8-A140	BRCA	TCGA	PPMY	ITCH	703:706	Mutation altering degron motif	0.7087
p.Y706C	DO2204	BRCA	ICGC	PPMY	ITCH	703:706	Mutation altering degron motif	0.7087
p.N715K	TCGA-EO-A22X	UCEC	TCGA	PPMY	ITCH	703:706	Mutation rewiring degron network	0.0833
p.N715K	DO43907	UCEC	ICGC	PPMY	ITCH	703:706	Mutation rewiring degron network	0.0833
p.R708Q	TCGA-EW-A1OV	BRCA	TCGA	PPMY	ITCH	703:706	Mutation rewiring degron network	0.2778
p.R708Q	DO1550	BRCA	ICGC	PPMY	ITCH	703:706	Mutation rewiring degron network	0.2778
p.A907T	TCGA-VQ-A8PP	STAD	TCGA	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation rewiring degron network	0.0833
p.A907T	DO51774	STAD	ICGC	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation rewiring degron network	0.0833
p.R699H	TCGA-XK-AAIW	PRAD	TCGA	PPMY	ITCH	703:706	Mutation rewiring degron network	0.2222
p.R699H	DO51407	PRAD	ICGC	PPMY	ITCH	703:706	Mutation rewiring degron network	0.2222
p.P693S	DO224805	BRCA	ICGC	PPMY	ITCH	703:706	Mutation rewiring degron network	0.0556
p.P693S	DO52546	BRCA	ICGC	PPMY	ITCH	703:706	Mutation rewiring degron network	0.0556
p.P900H	DO228912	LICA	ICGC	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation rewiring degron network	0.2778
p.A907E	DO228976	LICA	ICGC	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation rewiring degron network	0.0833
p.R702H	DO228138	PBCA	ICGC	PPMY	ITCH	703:706	Mutation rewiring degron network	0.3056
p.R702H	SIDM00213	Thyroid Gland Carcinoma	GDSC	PPMY	ITCH	703:706	Mutation rewiring degron network	0.3056
p.R702H	ACH-000903	Thyroid Cancer	CCLE	PPMY	ITCH	703:706	Mutation rewiring degron network	0.3056
p.R702H	FTC-133	thyroid	COSMIC	PPMY	ITCH	703:706	Mutation rewiring degron network	0.3056
p.R702C	SIDM00373	Endometrial Carcinoma	GDSC	PPMY	ITCH	703:706	Mutation rewiring degron network	0.3056
p.R702C	ACH-000974	Endometrial/Uterine Cancer	CCLE	PPMY	ITCH	703:706	Mutation rewiring degron network	0.3056
p.P704A	SIDM00845	Burkitt's Lymphoma	GDSC	PPMY	ITCH	703:706	Mutation altering degron motif	0.7503
p.P704A	SIDM00035	Thyroid Gland Carcinoma	GDSC	PPMY	ITCH	703:706	Mutation altering degron motif	0.7503
p.P704A	SIDM00461	Acute Myeloid Leukemia	GDSC	PPMY	ITCH	703:706	Mutation altering degron motif	0.7503
p.P704A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PPMY	ITCH	703:706	Mutation altering degron motif	0.7503
p.P704A	SIDM01519	Head and Neck Carcinoma	GDSC	PPMY	ITCH	703:706	Mutation altering degron motif	0.7503
p.P704A	ACH-000037	Sarcoma	CCLE	PPMY	ITCH	703:706	Mutation altering degron motif	0.7503
p.P704A	ACH-000786	Lymphoma	CCLE	PPMY	ITCH	703:706	Mutation altering degron motif	0.7503
p.P704A	S-117	soft tissue	COSMIC	PPMY	ITCH	703:706	Mutation altering degron motif	0.7503
p.P704A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PPMY	ITCH	703:706	Mutation altering degron motif	0.7503
p.P704A	DND-41	haematopoietic and lymphoid tissue	COSMIC	PPMY	ITCH	703:706	Mutation altering degron motif	0.7503
p.P704A	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPMY	ITCH	703:706	Mutation altering degron motif	0.7503
p.P900L	SIDM01146	Gastric Carcinoma	GDSC	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation rewiring degron network	0.2778
p.P900L	ACH-000932	Gastric Cancer	CCLE	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation rewiring degron network	0.2778
p.P900L	NCI-SNU-1	stomach	COSMIC	IIPFSD	LIG_APCC_ABBA_1	893:898	Mutation rewiring degron network	0.2778
p.M705V	SIDM01525	Acute Myeloid Leukemia	GDSC	PPMY	ITCH	703:706	Mutation altering degron motif	0.6097
p.M705V	ACH-000557	Leukemia	CCLE	PPMY	ITCH	703:706	Mutation altering degron motif	0.6097

Kaplan plot for RC3H2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RC3H2

UniProt ID: Q9HBD1

Entrez ID: 54542

Protein name: Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RC3H2 in