DegronMD

Uniprot ID: Q9HBD1

Source protein: Roquin-2

Source gene: RC3H2

Class: LIG_APCC_ABBA_1

Location: 893:898

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9952

ASA_SCORE: 60.6167

COIL: 0.8388

CONS_SCORE: 0.3867

DSS_SCORE: 0.488

HELIX: 0.0398

FCONS_SCORE: 0.8908

RIG_SCORE: 0.7764

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R886M	TCGA-05-4382	LUAD	TCGA	IIPFSD	LIG_APCC_ABBA_1	0.1389
p.R886M	DO24900	LUAD	ICGC	IIPFSD	LIG_APCC_ABBA_1	0.1389
p.A907V	TCGA-06-5858	GBM	TCGA	IIPFSD	LIG_APCC_ABBA_1	0.0833
p.A907V	TCGA-21-1080	LUSC	TCGA	IIPFSD	LIG_APCC_ABBA_1	0.0833
p.A907V	TCGA-FI-A2D5	UCEC	TCGA	IIPFSD	LIG_APCC_ABBA_1	0.0833
p.A907V	DO228935	COCA	ICGC	IIPFSD	LIG_APCC_ABBA_1	0.0833
p.A907V	DO10892	GBM	ICGC	IIPFSD	LIG_APCC_ABBA_1	0.0833
p.A907V	DO26502	LUSC	ICGC	IIPFSD	LIG_APCC_ABBA_1	0.0833
p.A907V	DO41331	UCEC	ICGC	IIPFSD	LIG_APCC_ABBA_1	0.0833
p.A907V	ACH-001369	Ovarian Cancer	CCLE	IIPFSD	LIG_APCC_ABBA_1	0.0833
p.I893R	TCGA-95-7567	LUAD	TCGA	IIPFSD	LIG_APCC_ABBA_1	0.8102
p.I893R	DO25564	LUAD	ICGC	IIPFSD	LIG_APCC_ABBA_1	0.8102
p.P895S	TCGA-AJ-A3EK	UCEC	TCGA	IIPFSD	LIG_APCC_ABBA_1	0.6752
p.P895S	TCGA-EE-A2GB	SKCM	TCGA	IIPFSD	LIG_APCC_ABBA_1	0.6752
p.P895S	TCGA-EE-A3AE	SKCM	TCGA	IIPFSD	LIG_APCC_ABBA_1	0.6752
p.P895S	DO222683	MELA	ICGC	IIPFSD	LIG_APCC_ABBA_1	0.6752
p.P895S	DO37802	SKCM	ICGC	IIPFSD	LIG_APCC_ABBA_1	0.6752
p.P895S	DO37417	SKCM	ICGC	IIPFSD	LIG_APCC_ABBA_1	0.6752
p.P895S	DO41584	UCEC	ICGC	IIPFSD	LIG_APCC_ABBA_1	0.6752
p.P892S	TCGA-B5-A3FC	UCEC	TCGA	IIPFSD	LIG_APCC_ABBA_1	0.3056
p.P892S	TCGA-EE-A3JD	SKCM	TCGA	IIPFSD	LIG_APCC_ABBA_1	0.3056
p.P892S	DO50299	SKCM	ICGC	IIPFSD	LIG_APCC_ABBA_1	0.3056
p.P892S	DO41871	UCEC	ICGC	IIPFSD	LIG_APCC_ABBA_1	0.3056
p.A907T	TCGA-VQ-A8PP	STAD	TCGA	IIPFSD	LIG_APCC_ABBA_1	0.0833
p.A907T	DO51774	STAD	ICGC	IIPFSD	LIG_APCC_ABBA_1	0.0833
p.P900H	DO228912	LICA	ICGC	IIPFSD	LIG_APCC_ABBA_1	0.2778
p.A907E	DO228976	LICA	ICGC	IIPFSD	LIG_APCC_ABBA_1	0.0833
p.P900L	SIDM01146	Gastric Carcinoma	GDSC	IIPFSD	LIG_APCC_ABBA_1	0.2778
p.P900L	ACH-000932	Gastric Cancer	CCLE	IIPFSD	LIG_APCC_ABBA_1	0.2778
p.P900L	NCI-SNU-1	stomach	COSMIC	IIPFSD	LIG_APCC_ABBA_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IIPFSD

Degron related mutations and impact score

Drug responses associated with RC3H2 mutations

All proteins holding degron of IIPFSD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HBD1	Roquin-2	LIG_APCC_ABBA_1	893:898	IIPFSD	APC,CDC20,FZR1	0.9952	More...