DegronMD

Uniprot ID: Q9HCF6

Source protein: Transient receptor potential cation channel subfamily M member 3

Source gene: TRPM3

Class: ITCH

Location: 1515:1518

E3 ligase: ITCH,NEDD4

DEGRON score: 0.8817

ASA_SCORE: 72.55

COIL: 0.8493

CONS_SCORE: 0.331

DSS_SCORE: 0.5442

HELIX: 0.1195

FCONS_SCORE: 1.1142

RIG_SCORE: 0.691

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1526F	TCGA-BS-A0UV	UCEC	TCGA	PPMY	ITCH	0.1111
p.S1520P	TCGA-EI-6917	READ	TCGA	PPMY	ITCH	0.2778
p.L1505I	TCGA-IQ-A61J	HNSC	TCGA	PPMY	ITCH	0.0556
p.Y1510C	DO48566	BLCA	ICGC	PPMY	ITCH	0.1944
p.R1506C	DO48566	BLCA	ICGC	PPMY	ITCH	0.0833
p.E1513K	DO2819	BRCA	ICGC	PPMY	ITCH	0.2778
p.K1524N	DO2401	BRCA	ICGC	PPMY	ITCH	0.1667
p.A1507T	DO7798	COAD	ICGC	PPMY	ITCH	0.1111
p.A1517V	DO222884	COCA	ICGC	PPMY	ITCH	0.6936
p.A1517V	DO51761	STAD	ICGC	PPMY	ITCH	0.6936
p.E1505K	DO52079	HNSC	ICGC	PPMY	ITCH	0.0556
p.E1514K	DO37786	SKCM	ICGC	PPMY	ITCH	0.3056
p.E1514K	SIDM01504	Small Cell Lung Carcinoma	GDSC	PPMY	ITCH	0.3056
p.E1514K	ACH-000594	Lung Cancer	CCLE	PPMY	ITCH	0.3056
p.A1520T	DO38328	STAD	ICGC	PPMY	ITCH	0.2778
p.E1513D	DO41644	UCEC	ICGC	PPMY	ITCH	0.2778
p.S1527F	DO43755	UCEC	ICGC	PPMY	ITCH	0.0833
p.I1528V	DO41361	UCEC	ICGC	PPMY	ITCH	0.0556
p.F1523I	SIDM01296	Esophageal Carcinoma	GDSC	PPMY	ITCH	0.1944
p.L1511V	SIDM00189	Melanoma	GDSC	PPMY	ITCH	0.2222
p.L1511V	ACH-002098	Skin Cancer	CCLE	PPMY	ITCH	0.2222
p.L1511V	CP67-MEL	skin	COSMIC	PPMY	ITCH	0.2222
p.A1515V	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PPMY	ITCH	0.6936
p.A1515V	H513	pleura	COSMIC	PPMY	ITCH	0.6936
p.A1526S	201T	lung	COSMIC	PPMY	ITCH	0.1111
p.D1507N	SW684	soft_tissue	COSMIC	PPMY	ITCH	0.1111
p.D1517N	SW684	soft_tissue	COSMIC	PPMY	ITCH	0.6932
p.R1506H	KMRC-1	kidney	COSMIC	PPMY	ITCH	0.0833
p.R1506H	HUH-6-clone5	liver	COSMIC	PPMY	ITCH	0.0833
p.R1506H	HuO-3N1	bone	COSMIC	PPMY	ITCH	0.0833
p.R1506H	SKG-IIIa	cervix	COSMIC	PPMY	ITCH	0.0833
p.R1506H	G-402	soft_tissue	COSMIC	PPMY	ITCH	0.0833
p.A1516S	201T	lung	COSMIC	PPMY	ITCH	0.7588
p.D1520N	SW684	soft_tissue	COSMIC	PPMY	ITCH	0.2778
p.A1512P	NCI-H720	lung	COSMIC	PPMY	ITCH	0.25
p.L1515V	CP67-MEL	skin	COSMIC	PPMY	ITCH	0.6765
p.A1519V	H513	pleura	COSMIC	PPMY	ITCH	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13521	Secretogranin-2	ITCH	167:170	PPMY	ITCH,NEDD4	0.519	More...
Q01954	Zinc finger protein basonuclin-1	ITCH	74:77	PPMY	ITCH,NEDD4	0.8829	More...
Q86VH2	Kinesin-like protein KIF27	ITCH	608:611	PPMY	ITCH,NEDD4	0.6139	More...
Q86WA8	Lon protease homolog 2, peroxisomal	ITCH	640:643	PPMY	ITCH,NEDD4	0.768	More...
Q96LT9	RNA-binding region-containing protein 3	ITCH	206:209	PPMY	ITCH,NEDD4	0.9928	More...
Q9HBD1	Roquin-2	ITCH	703:706	PPMY	ITCH,NEDD4	0.9939	More...
Q9HCF6	Transient receptor potential cation channel subfamily M member 3	ITCH	1515:1518	PPMY	ITCH,NEDD4	0.8817	More...
Q9NRJ4	Tubby-related protein 4	ITCH	1241:1244	PPMY	ITCH,NEDD4	0.769	More...
O15255	CAAX box protein 1	ITCH	94:97	PPMY	ITCH,NEDD4	0.956	More...
Q8NA69	Testis-expressed protein 45	ITCH	496:499	PPMY	ITCH,NEDD4	0.9984	More...
Q9P281	BAH and coiled-coil domain-containing protein 1	ITCH	901:904	PPMY	ITCH,NEDD4	0.9559	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPMY

Degron related mutations and impact score

Drug responses associated with TRPM3 mutations

All proteins holding degron of PPMY