DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPMY
Uniprot ID:
Q01954
Source protein:
Zinc finger protein basonuclin-1
Source gene:
BNC1
Class:
ITCH
Location:
74:77
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.8829
ASA_SCORE:
77.775
COIL:
0.927
CONS_SCORE:
0.3043
DSS_SCORE:
0.1766
HELIX:
0.0245
FCONS_SCORE:
0.7398
RIG_SCORE:
0.7635
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q81P
TCGA-A5-A1OF
UCEC
TCGA
PPMY
ITCH
0.2222
p.Q81P
DO42568
UCEC
ICGC
PPMY
ITCH
0.2222
p.P74H
TCGA-CM-5864
COAD
TCGA
PPMY
ITCH
0.7694
p.P74H
DO8690
COAD
ICGC
PPMY
ITCH
0.7694
p.P74S
TCGA-CU-A0YN
BLCA
TCGA
PPMY
ITCH
0.6752
p.P74S
DO488
BLCA
ICGC
PPMY
ITCH
0.6752
p.A67S
TCGA-DF-A2KN
UCEC
TCGA
PPMY
ITCH
0.1389
p.A67S
DO223282
UCEC
ICGC
PPMY
ITCH
0.1389
p.R72G
TCGA-FI-A2F4
UCEC
TCGA
PPMY
ITCH
0.2778
p.R72G
DO43434
UCEC
ICGC
PPMY
ITCH
0.2778
p.A65V
TCGA-FR-A726
SKCM
TCGA
PPMY
ITCH
0.0833
p.A65V
DO48665
SKCM
ICGC
PPMY
ITCH
0.0833
p.E83K
TCGA-QB-AA9O
SKCM
TCGA
PPMY
ITCH
0.1667
p.E83K
DO51267
SKCM
ICGC
PPMY
ITCH
0.1667
p.A67T
TCGA-VS-A9U6
CESC
TCGA
PPMY
ITCH
0.1389
p.A67T
DO219728
CESC
ICGC
PPMY
ITCH
0.1389
p.A67T
SIDM02059
Colorectal Carcinoma
GDSC
PPMY
ITCH
0.1389
p.Q86L
SIDM00425
Ovarian Carcinoma
GDSC
PPMY
ITCH
0.0833
p.Q86L
OVTOKO
ovary
COSMIC
PPMY
ITCH
0.0833
p.L68I
SIDM00120
Prostate Carcinoma
GDSC
PPMY
ITCH
0.1667
p.L68I
DU-145
prostate
COSMIC
PPMY
ITCH
0.1667
p.V83L
ACH-000410
Bone Cancer
CCLE
PPMY
ITCH
0.1667
p.V83L
Saos-2
bone
COSMIC
PPMY
ITCH
0.1667
p.Q79L
ACH-000663
Ovarian Cancer
CCLE
PPMY
ITCH
0.2778
p.Q79L
OVTOKO
ovary
COSMIC
PPMY
ITCH
0.2778
Drug responses associated with BNC1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPMY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P13521
Secretogranin-2
ITCH
167:170
PPMY
ITCH,NEDD4
0.519
More...
Q01954
Zinc finger protein basonuclin-1
ITCH
74:77
PPMY
ITCH,NEDD4
0.8829
More...
Q86VH2
Kinesin-like protein KIF27
ITCH
608:611
PPMY
ITCH,NEDD4
0.6139
More...
Q86WA8
Lon protease homolog 2, peroxisomal
ITCH
640:643
PPMY
ITCH,NEDD4
0.768
More...
Q96LT9
RNA-binding region-containing protein 3
ITCH
206:209
PPMY
ITCH,NEDD4
0.9928
More...
Q9HBD1
Roquin-2
ITCH
703:706
PPMY
ITCH,NEDD4
0.9939
More...
Q9HCF6
Transient receptor potential cation channel subfamily M member 3
ITCH
1515:1518
PPMY
ITCH,NEDD4
0.8817
More...
Q9NRJ4
Tubby-related protein 4
ITCH
1241:1244
PPMY
ITCH,NEDD4
0.769
More...
O15255
CAAX box protein 1
ITCH
94:97
PPMY
ITCH,NEDD4
0.956
More...
Q8NA69
Testis-expressed protein 45
ITCH
496:499
PPMY
ITCH,NEDD4
0.9984
More...
Q9P281
BAH and coiled-coil domain-containing protein 1
ITCH
901:904
PPMY
ITCH,NEDD4
0.9559
More...