DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
TEX45
UniProt ID:
Q8NA69
Entrez ID:
374877
Protein name:
Testis-expressed protein 45
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
TEX45
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.A295V
SIDM02049
Pancreatic Carcinoma
GDSC
FVLHHD
LIG_APCC_ABBA_1
301:306
Mutation rewiring degron network
0.1667
p.D490E
SIDM00361
Non-Small Cell Lung Carcinoma
GDSC
PPMY
ITCH
496:499
Mutation rewiring degron network
0.1667
p.D490E
PC-3_[JPC-3]
lung
COSMIC
PPMY
ITCH
496:499
Mutation rewiring degron network
0.1667
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for TEX45 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc