DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
FVLHHD
Uniprot ID:
Q8NA69
Source protein:
Testis-expressed protein 45
Source gene:
TEX45
Class:
LIG_APCC_ABBA_1
Location:
301:306
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8325
ASA_SCORE:
77.2167
COIL:
0.6228
CONS_SCORE:
0.2882
DSS_SCORE:
0.4988
HELIX:
0.0373
FCONS_SCORE:
0.6389
RIG_SCORE:
0.7366
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A295V
SIDM02049
Pancreatic Carcinoma
GDSC
FVLHHD
LIG_APCC_ABBA_1
0.1667
Drug responses associated with TEX45 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of FVLHHD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NA69
Testis-expressed protein 45
LIG_APCC_ABBA_1
301:306
FVLHHD
APC,CDC20,FZR1
0.8325
More...