DegronMD - Q9NRJ4(TULP4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1239S	TCGA-12-3651	GBM	TCGA	PPMY	ITCH	1241:1244	Mutation rewiring degron network	0.2778
p.T1239S	DO13845	GBM	ICGC	PPMY	ITCH	1241:1244	Mutation rewiring degron network	0.2778
p.G1017S	TCGA-2Y-A9GU	LIHC	TCGA	PRAPLQPLA	DEG_APCC_DBOX_1	1005:1013	Mutation rewiring degron network	0.2222
p.G1017S	DO234308	ESAD	ICGC	PRAPLQPLA	DEG_APCC_DBOX_1	1005:1013	Mutation rewiring degron network	0.2222
p.G1017S	DO219507	LIHC	ICGC	PRAPLQPLA	DEG_APCC_DBOX_1	1005:1013	Mutation rewiring degron network	0.2222
p.Y961C	TCGA-46-3768	LUSC	TCGA	PPPY	ITCH	958:961	Mutation altering degron motif	0.7087
p.Y961C	DO26466	LUSC	ICGC	PPPY	ITCH	958:961	Mutation altering degron motif	0.7087
p.C1250Y	TCGA-55-8089	LUAD	TCGA	PPMY	ITCH	1241:1244	Mutation rewiring degron network	0.1667
p.C1250Y	DO23690	LUAD	ICGC	PPMY	ITCH	1241:1244	Mutation rewiring degron network	0.1667
p.S1251C	TCGA-77-7141	LUSC	TCGA	PPMY	ITCH	1241:1244	Mutation rewiring degron network	0.1389
p.S1251C	DO26450	LUSC	ICGC	PPMY	ITCH	1241:1244	Mutation rewiring degron network	0.1389
p.V1132F	TCGA-78-8655	LUAD	TCGA	PPPY	ITCH	1119:1122	Mutation rewiring degron network	0.0556
p.V1132F	DO45403	LUAD	ICGC	PPPY	ITCH	1119:1122	Mutation rewiring degron network	0.0556
p.V948I	TCGA-AA-3672	COAD	TCGA	PPPY	ITCH	958:961	Mutation rewiring degron network	0.0556
p.V948I	DO9010	COAD	ICGC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.0556
p.V948I	SIDM00988	Kidney Carcinoma	GDSC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.0556
p.V948I	SIDM00192	Colorectal Carcinoma	GDSC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.0556
p.V948I	BFTC-909	kidney	COSMIC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.0556
p.S1234I	TCGA-AP-A051	UCEC	TCGA	PPMY	ITCH	1241:1244	Mutation rewiring degron network	0.1389
p.S1234I	DO42673	UCEC	ICGC	PPMY	ITCH	1241:1244	Mutation rewiring degron network	0.1389
p.P1110S	TCGA-BS-A0U8	UCEC	TCGA	PPPY	ITCH	1119:1122	Mutation rewiring degron network	0.0833
p.P1110S	DO41380	UCEC	ICGC	PPPY	ITCH	1119:1122	Mutation rewiring degron network	0.0833
p.K830N	TCGA-CK-4951	COAD	TCGA	PPPY	ITCH	834:837	Mutation substituting flanking lysine	0.3333
p.K830N	DO10582	COAD	ICGC	PPPY	ITCH	834:837	Mutation substituting flanking lysine	0.3333
p.R950C	TCGA-CM-4746	COAD	TCGA	PPPY	ITCH	958:961	Mutation rewiring degron network	0.1111
p.R950C	DO7882	COAD	ICGC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.1111
p.R950C	SIDM00585	Hepatocellular Carcinoma	GDSC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.1111
p.R950C	HuH-7	liver	COSMIC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.1111
p.D1003N	TCGA-CQ-7071	HNSC	TCGA	PRAPLQPLA	DEG_APCC_DBOX_1	1005:1013	Mutation rewiring degron network	0.2778
p.D1003N	DO49069	HNSC	ICGC	PRAPLQPLA	DEG_APCC_DBOX_1	1005:1013	Mutation rewiring degron network	0.2778
p.S1236F	TCGA-CV-7089	HNSC	TCGA	PPMY	ITCH	1241:1244	Mutation rewiring degron network	0.1944
p.S1236F	DO15158	HNSC	ICGC	PPMY	ITCH	1241:1244	Mutation rewiring degron network	0.1944
p.R1118W	TCGA-D5-6540	COAD	TCGA	PPPY	ITCH	1119:1122	Mutation rewiring degron network	0.3056
p.R1118W	DO9708	COAD	ICGC	PPPY	ITCH	1119:1122	Mutation rewiring degron network	0.3056
p.R1118W	SIDM00539	Esophageal Carcinoma	GDSC	PPPY	ITCH	1119:1122	Mutation rewiring degron network	0.3056
p.R1118W	ACH-001496	Esophageal Cancer	CCLE	PPPY	ITCH	1119:1122	Mutation rewiring degron network	0.3056
p.R1118W	ESO26	oesophagus	COSMIC	PPPY	ITCH	1119:1122	Mutation rewiring degron network	0.3056
p.P1121A	TCGA-L5-A88W	ESCA	TCGA	PPPY	ITCH	1119:1122	Mutation altering degron motif	0.6392
p.A965V	TCGA-VQ-A91K	STAD	TCGA	PPPY	ITCH	958:961	Mutation rewiring degron network	0.2222
p.A965V	DO51785	STAD	ICGC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.2222
p.R1118Q	TCGA-WE-A8ZN	SKCM	TCGA	PPPY	ITCH	1119:1122	Mutation rewiring degron network	0.3056
p.R1118Q	DO51285	SKCM	ICGC	PPPY	ITCH	1119:1122	Mutation rewiring degron network	0.3056
p.P1242S	DO222441	ESCA	ICGC	PPMY	ITCH	1241:1244	Mutation altering degron motif	0.6752
p.R1006W	DO233871	GACA	ICGC	PRAPLQPLA	DEG_APCC_DBOX_1	1005:1013	Mutation altering degron motif	0.8634
p.G1129R	DO231155	LUSC	ICGC	PPPY	ITCH	1119:1122	Mutation rewiring degron network	0.1389
p.P1011L	DO222653	MELA	ICGC	PRAPLQPLA	DEG_APCC_DBOX_1	1005:1013	Mutation altering degron motif	0.6471
p.L1109M	DO228582	PRAD	ICGC	PPPY	ITCH	1119:1122	Mutation rewiring degron network	0.0556
p.P836L	SIDM02059	Colorectal Carcinoma	GDSC	PPPY	ITCH	834:837	Mutation altering degron motif	0.6471
p.E963Q	SIDM00509	Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.2778
p.E963Q	ACH-000187	Lung Cancer	CCLE	PPPY	ITCH	958:961	Mutation rewiring degron network	0.2778
p.E963Q	COR-L311	lung	COSMIC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.2778
p.E825D	SIDM00499	Prostate Carcinoma	GDSC	PPPY	ITCH	834:837	Mutation rewiring degron network	0.0833
p.E825D	ACH-000956	Prostate Cancer	CCLE	PPPY	ITCH	834:837	Mutation rewiring degron network	0.0833
p.E825D	22RV1	prostate	COSMIC	PPPY	ITCH	834:837	Mutation rewiring degron network	0.0833
p.P1120R	SIDM00330	Neuroblastoma	GDSC	PPPY	ITCH	1119:1122	Mutation altering degron motif	0.7512
p.P1120R	ACH-001355	Neuroblastoma	CCLE	PPPY	ITCH	1119:1122	Mutation altering degron motif	0.7512
p.P1120R	LAN-6	autonomic ganglia	COSMIC	PPPY	ITCH	1119:1122	Mutation altering degron motif	0.7512
p.P949S	SIDM00496	Thyroid Gland Carcinoma	GDSC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.0833
p.P949S	SIDM00291	Melanoma	GDSC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.0833
p.P949S	SIDM00057	Neuroblastoma	GDSC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.0833
p.P949S	SIDM00552	Rhabdomyosarcoma	GDSC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.0833
p.P949S	SIDM00549	B-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.0833
p.P949S	KYM-1	soft tissue	COSMIC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.0833
p.P949S	HTC-C3	thyroid	COSMIC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.0833
p.P949S	HMV-II	skin	COSMIC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.0833
p.P949S	LC4-1	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.0833
p.R950H	SIDM00660	Colorectal Carcinoma	GDSC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.1111
p.R950H	ACH-000985	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	958:961	Mutation rewiring degron network	0.1111
p.R950H	LS-411N	large intestine	COSMIC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.1111
p.A969V	SIDM00619	Thyroid Gland Carcinoma	GDSC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.1111
p.A969V	KMH-2	thyroid	COSMIC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.1111
p.A969T	SIDM00516	Melanoma	GDSC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.1111
p.A969T	ACH-002166	Skin Cancer	CCLE	PPPY	ITCH	958:961	Mutation rewiring degron network	0.1111
p.A969T	MZ7-mel	skin	COSMIC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.1111
p.Y1122C	SIDM00312	Plasma Cell Myeloma	GDSC	PPPY	ITCH	1119:1122	Mutation altering degron motif	0.7087
p.Y1122C	ACH-000183	Myeloma	CCLE	PPPY	ITCH	1119:1122	Mutation altering degron motif	0.7087
p.Y1122C	L-363	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	1119:1122	Mutation altering degron motif	0.7087
p.P954L	SIDM01750	Melanoma	GDSC	PPPY	ITCH	958:961	Mutation rewiring degron network	0.2222
p.P954L	ACH-000801	Skin Cancer	CCLE	PPPY	ITCH	958:961	Mutation rewiring degron network	0.2222
p.I831M	ACH-001061	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	834:837	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TULP4

UniProt ID: Q9NRJ4

Entrez ID: 56995

Protein name: Tubby-related protein 4 (Tubby superfamily protein) (Tubby-like protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TULP4 in