DegronMD

Uniprot ID: Q9NRJ4

Source protein: Tubby-related protein 4

Source gene: TULP4

Class: DEG_APCC_DBOX_1

Location: 1005:1013

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9241

ASA_SCORE: 87.0667

COIL: 0.937

CONS_SCORE: 0.3309

DSS_SCORE: 0.6212

HELIX: 0.0292

FCONS_SCORE: 0.9788

RIG_SCORE: 0.662

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1017S	TCGA-2Y-A9GU	LIHC	TCGA	PRAPLQPLA	DEG_APCC_DBOX_1	0.2222
p.G1017S	DO234308	ESAD	ICGC	PRAPLQPLA	DEG_APCC_DBOX_1	0.2222
p.G1017S	DO219507	LIHC	ICGC	PRAPLQPLA	DEG_APCC_DBOX_1	0.2222
p.D1003N	TCGA-CQ-7071	HNSC	TCGA	PRAPLQPLA	DEG_APCC_DBOX_1	0.2778
p.D1003N	DO49069	HNSC	ICGC	PRAPLQPLA	DEG_APCC_DBOX_1	0.2778
p.R1006W	DO233871	GACA	ICGC	PRAPLQPLA	DEG_APCC_DBOX_1	0.8634
p.P1011L	DO222653	MELA	ICGC	PRAPLQPLA	DEG_APCC_DBOX_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRJ4	Tubby-related protein 4	DEG_APCC_DBOX_1	1005:1013	PRAPLQPLA	APC,CDC20,FZR1	0.9241	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons