DegronMD

Uniprot ID: Q9NRJ4

Source protein: Tubby-related protein 4

Source gene: TULP4

Class: ITCH

Location: 958:961

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9994

ASA_SCORE: 80.65

COIL: 0.9515

CONS_SCORE: 0.427

DSS_SCORE: 0.5954

HELIX: 0.0155

FCONS_SCORE: 1.0683

RIG_SCORE: 0.6447

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y961C	TCGA-46-3768	LUSC	TCGA	PPPY	ITCH	0.7087
p.Y961C	DO26466	LUSC	ICGC	PPPY	ITCH	0.7087
p.E963Q	SIDM00509	Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	0.2778
p.E963Q	ACH-000187	Lung Cancer	CCLE	PPPY	ITCH	0.2778
p.E963Q	COR-L311	lung	COSMIC	PPPY	ITCH	0.2778
p.A965V	TCGA-VQ-A91K	STAD	TCGA	PPPY	ITCH	0.2222
p.A965V	DO51785	STAD	ICGC	PPPY	ITCH	0.2222
p.P954L	SIDM01750	Melanoma	GDSC	PPPY	ITCH	0.2222
p.P954L	ACH-000801	Skin Cancer	CCLE	PPPY	ITCH	0.2222
p.R950C	TCGA-CM-4746	COAD	TCGA	PPPY	ITCH	0.1111
p.R950C	DO7882	COAD	ICGC	PPPY	ITCH	0.1111
p.R950C	SIDM00585	Hepatocellular Carcinoma	GDSC	PPPY	ITCH	0.1111
p.R950C	HuH-7	liver	COSMIC	PPPY	ITCH	0.1111
p.R950H	SIDM00660	Colorectal Carcinoma	GDSC	PPPY	ITCH	0.1111
p.R950H	ACH-000985	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	0.1111
p.R950H	LS-411N	large_intestine	COSMIC	PPPY	ITCH	0.1111
p.A969V	SIDM00619	Thyroid Gland Carcinoma	GDSC	PPPY	ITCH	0.1111
p.A969V	KMH-2	thyroid	COSMIC	PPPY	ITCH	0.1111
p.A969T	SIDM00516	Melanoma	GDSC	PPPY	ITCH	0.1111
p.A969T	ACH-002166	Skin Cancer	CCLE	PPPY	ITCH	0.1111
p.A969T	MZ7-mel	skin	COSMIC	PPPY	ITCH	0.1111
p.P949S	SIDM00496	Thyroid Gland Carcinoma	GDSC	PPPY	ITCH	0.0833
p.P949S	SIDM00291	Melanoma	GDSC	PPPY	ITCH	0.0833
p.P949S	SIDM00057	Neuroblastoma	GDSC	PPPY	ITCH	0.0833
p.P949S	SIDM00552	Rhabdomyosarcoma	GDSC	PPPY	ITCH	0.0833

Showing 1 to 25 of 35 entries

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Drug responses associated with TULP4 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPPY

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96DV4	39S ribosomal protein L38, mitochondrial	ITCH	347:350	PPPY	ITCH,NEDD4	0.6466	More...
O15072	A disintegrin and metalloproteinase with thrombospondin motifs 3	ITCH	1058:1061	PPPY	ITCH,NEDD4	0.9797	More...
Q13625	Apoptosis-stimulating of p53 protein 2	ITCH	871:874	PPPY	ITCH,NEDD4	0.9885	More...
P54259	Atrophin-1	ITCH	445:448	PPPY	ITCH,NEDD4	0.973	More...
P54259	Atrophin-1	ITCH	636:639	PPPY	ITCH,NEDD4	0.9909	More...
Q8WXX7	Autism susceptibility gene 2 protein	ITCH	516:519	PPPY	ITCH,NEDD4	0.9979	More...
O00512	B-cell CLL/lymphoma 9 protein	ITCH	515:518	PPPY	ITCH,NEDD4	0.9973	More...
Q86UU0	B-cell CLL/lymphoma 9-like protein	ITCH	561:564	PPPY	ITCH,NEDD4	0.9923	More...
O95395	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3	ITCH	285:288	PPPY	ITCH,NEDD4	0.5532	More...
O95415	Brain protein I3	ITCH	39:42	PPPY	ITCH,NEDD4	0.9496	More...
Q15018	BRISC complex subunit Abraxas 2	ITCH	305:308	PPPY	ITCH,NEDD4	0.9939	More...
Q9P203	BTB/POZ domain-containing protein 7	ITCH	762:765	PPPY	ITCH,NEDD4	0.9575	More...
Q9Y6W3	Calpain-7	ITCH	624:627	PPPY	ITCH,NEDD4	0.5393	More...
Q8WXE0	Caskin-2	ITCH	751:754	PPPY	ITCH,NEDD4	0.6879	More...
Q9H305	Cell death-inducing p53-target protein 1	ITCH	6:9	PPPY	ITCH,NEDD4	0.9945	More...
Q9H305	Cell death-inducing p53-target protein 1	ITCH	51:54	PPPY	ITCH,NEDD4	0.9943	More...
Q16630	Cleavage and polyadenylation specificity factor subunit 6	ITCH	387:390	PPPY	ITCH,NEDD4	0.9919	More...
Q8WXI2	Connector enhancer of kinase suppressor of ras 2	ITCH	704:707	PPPY	ITCH,NEDD4	0.9478	More...
Q86YQ8	Copine-8	ITCH	550:553	PPPY	ITCH,NEDD4	0.743	More...
Q6UUV7	CREB-regulated transcription coactivator 3	ITCH	445:448	PPPY	ITCH,NEDD4	0.998	More...
Q96J86	Cysteine and tyrosine-rich protein 1	ITCH	113:116	PPPY	ITCH,NEDD4	0.9396	More...
Q96J86	Cysteine and tyrosine-rich protein 1	ITCH	129:132	PPPY	ITCH,NEDD4	0.9428	More...
Q96J86	Cysteine and tyrosine-rich protein 1	ITCH	145:148	PPPY	ITCH,NEDD4	0.9794	More...
Q9H1C7	Cysteine-rich and transmembrane domain-containing protein 1	ITCH	6:9	PPPY	ITCH,NEDD4	0.9391	More...
Q9BTC0	Death-inducer obliterator 1	ITCH	1817:1820	PPPY	ITCH,NEDD4	0.9967	More...

Showing 1 to 25 of 180 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPPY

Degron related mutations and impact score

Drug responses associated with TULP4 mutations

All proteins holding degron of PPPY