DegronMD - Q96G27(WBP1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D129Y	TCGA-21-1082	LUSC	TCGA	PPAY	ITCH	124:127	Mutation rewiring degron network	0.2778
p.D129Y	TCGA-21-1082	LUSC	TCGA	PPPY	ITCH	138:141	Mutation rewiring degron network	0.0833
p.D129Y	DO26463	LUSC	ICGC	PPAY	ITCH	124:127	Mutation rewiring degron network	0.2778
p.D129Y	DO26463	LUSC	ICGC	PPPY	ITCH	138:141	Mutation rewiring degron network	0.0833
p.G191R	TCGA-AJ-A8CW	UCEC	TCGA	EPGAGVTPA	DEG_SIAH_1	189:197	Mutation altering degron motif	0.6457
p.G191R	DO223583	CLLE	ICGC	EPGAGVTPA	DEG_SIAH_1	189:197	Mutation altering degron motif	0.6457
p.G191R	DO52400	UCEC	ICGC	EPGAGVTPA	DEG_SIAH_1	189:197	Mutation altering degron motif	0.6457
p.R133H	TCGA-AX-A2HC	UCEC	TCGA	PPAY	ITCH	124:127	Mutation rewiring degron network	0.1667
p.R133H	TCGA-AX-A2HC	UCEC	TCGA	PPPY	ITCH	138:141	Mutation rewiring degron network	0.1944
p.R133H	DO41572	UCEC	ICGC	PPAY	ITCH	124:127	Mutation rewiring degron network	0.1667
p.R133H	DO41572	UCEC	ICGC	PPPY	ITCH	138:141	Mutation rewiring degron network	0.1944
p.G135C	TCGA-B5-A3FA	UCEC	TCGA	PPAY	ITCH	124:127	Mutation rewiring degron network	0.1111
p.G135C	TCGA-B5-A3FA	UCEC	TCGA	PPPY	ITCH	138:141	Mutation rewiring degron network	0.25
p.G135C	DO52402	UCEC	ICGC	PPAY	ITCH	124:127	Mutation rewiring degron network	0.1111
p.G135C	DO52402	UCEC	ICGC	PPPY	ITCH	138:141	Mutation rewiring degron network	0.25
p.R147C	TCGA-BT-A2LD	BLCA	TCGA	PPPY	ITCH	138:141	Mutation rewiring degron network	0.1667
p.R147C	DO578	BLCA	ICGC	PPPY	ITCH	138:141	Mutation rewiring degron network	0.1667
p.E128Q	TCGA-CR-7390	HNSC	TCGA	PPAY	ITCH	124:127	Mutation rewiring degron network	0.3056
p.E128Q	TCGA-CR-7390	HNSC	TCGA	PPPY	ITCH	138:141	Mutation rewiring degron network	0.0556
p.E128Q	DO14302	HNSC	ICGC	PPAY	ITCH	124:127	Mutation rewiring degron network	0.3056
p.E128Q	DO14302	HNSC	ICGC	PPPY	ITCH	138:141	Mutation rewiring degron network	0.0556
p.R206P	TCGA-KB-A93G	STAD	TCGA	VTPAST	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.1389
p.R206P	TCGA-KB-A93G	STAD	TCGA	EPGAGVTPA	DEG_SIAH_1	189:197	Mutation rewiring degron network	0.0833
p.R206P	DO222335	STAD	ICGC	VTPAST	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.1389
p.R206P	DO222335	STAD	ICGC	EPGAGVTPA	DEG_SIAH_1	189:197	Mutation rewiring degron network	0.0833
p.R117C	TCGA-ND-A4WC	UCS	TCGA	PPAY	ITCH	124:127	Mutation rewiring degron network	0.1389
p.R117C	TCGA-YC-A89H	BLCA	TCGA	PPAY	ITCH	124:127	Mutation rewiring degron network	0.1389
p.P184R	DO223007	ESCA	ICGC	VTPAST	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.0556
p.P184R	DO223007	ESCA	ICGC	EPGAGVTPA	DEG_SIAH_1	189:197	Mutation rewiring degron network	0.1944
p.P139T	DO233808	GACA	ICGC	PPPY	ITCH	138:141	Mutation altering degron motif	0.7031
p.V130A	DO233823	GACA	ICGC	PPAY	ITCH	124:127	Mutation rewiring degron network	0.25
p.V130A	DO233823	GACA	ICGC	PPPY	ITCH	138:141	Mutation rewiring degron network	0.1111
p.E187K	DO49683	LIAD	ICGC	VTPAST	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.1389
p.E187K	DO49683	LIAD	ICGC	EPGAGVTPA	DEG_SIAH_1	189:197	Mutation rewiring degron network	0.2778
p.V194G	DO48553	PAEN	ICGC	VTPAST	DEG_SCF_FBW7_1	194:199	Mutation altering degron motif	0.7532
p.V194G	DO48553	PAEN	ICGC	EPGAGVTPA	DEG_SIAH_1	189:197	Mutation altering degron motif	0.7532
p.A126T	DO232224	PBCA	ICGC	PPAY	ITCH	124:127	Mutation altering degron motif	0.6028
p.Y127N	SIDM00915	Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	124:127	Mutation altering degron motif	0.7059
p.Y127N	NCI-H378	lung	COSMIC	PPAY	ITCH	124:127	Mutation altering degron motif	0.7059
p.E128K	SIDM00602	Gastric Carcinoma	GDSC	PPAY	ITCH	124:127	Mutation rewiring degron network	0.3056
p.E128K	SIDM00602	Gastric Carcinoma	GDSC	PPPY	ITCH	138:141	Mutation rewiring degron network	0.0556
p.S181G	SIDM00120	Prostate Carcinoma	GDSC	EPGAGVTPA	DEG_SIAH_1	189:197	Mutation rewiring degron network	0.1111
p.S181G	DU-145	prostate	COSMIC	EPGAGVTPA	DEG_SIAH_1	189:197	Mutation rewiring degron network	0.1111
p.P140A	SIDM00643	Non-Cancerous	GDSC	PPPY	ITCH	138:141	Mutation altering degron motif	0.6392
p.P140A	SIDM01240	Melanoma	GDSC	PPPY	ITCH	138:141	Mutation altering degron motif	0.6392
p.P201A	SIDM01112	Osteosarcoma	GDSC	VTPAST	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.2778
p.P201A	SIDM01112	Osteosarcoma	GDSC	EPGAGVTPA	DEG_SIAH_1	189:197	Mutation rewiring degron network	0.2222
p.P201A	SIDM00529	Breast Carcinoma	GDSC	VTPAST	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.2778
p.P201A	SIDM00529	Breast Carcinoma	GDSC	EPGAGVTPA	DEG_SIAH_1	189:197	Mutation rewiring degron network	0.2222
p.G135S	SIDM00719	Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	124:127	Mutation rewiring degron network	0.1111
p.G135S	SIDM00719	Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	138:141	Mutation rewiring degron network	0.25
p.G135S	NCI-H345	lung	COSMIC	PPAY	ITCH	124:127	Mutation rewiring degron network	0.1111
p.G135S	NCI-H345	lung	COSMIC	PPPY	ITCH	138:141	Mutation rewiring degron network	0.25
p.H185N	SIDM01135	Pancreatic Carcinoma	GDSC	VTPAST	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.0833
p.H185N	SIDM01135	Pancreatic Carcinoma	GDSC	EPGAGVTPA	DEG_SIAH_1	189:197	Mutation rewiring degron network	0.2222
p.H185N	SIDM01525	Acute Myeloid Leukemia	GDSC	VTPAST	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.0833
p.H185N	SIDM01525	Acute Myeloid Leukemia	GDSC	EPGAGVTPA	DEG_SIAH_1	189:197	Mutation rewiring degron network	0.2222
p.H185N	PANC-10-05	pancreas	COSMIC	VTPAST	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.0833
p.H185N	PANC-10-05	pancreas	COSMIC	EPGAGVTPA	DEG_SIAH_1	189:197	Mutation rewiring degron network	0.2222
p.C203F	SIDM01133	Other Solid Cancers	GDSC	VTPAST	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.2222
p.C203F	SIDM01133	Other Solid Cancers	GDSC	EPGAGVTPA	DEG_SIAH_1	189:197	Mutation rewiring degron network	0.1667
p.C203F	NCI-H835	lung	COSMIC	VTPAST	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.2222
p.C203F	NCI-H835	lung	COSMIC	EPGAGVTPA	DEG_SIAH_1	189:197	Mutation rewiring degron network	0.1667
p.P140L	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	138:141	Mutation altering degron motif	0.6471
p.R207C	SIDM00118	Colorectal Carcinoma	GDSC	VTPAST	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.1111
p.R207C	SIDM00118	Colorectal Carcinoma	GDSC	EPGAGVTPA	DEG_SIAH_1	189:197	Mutation rewiring degron network	0.0556
p.R207C	ACH-001081	Colon/Colorectal Cancer	CCLE	VTPAST	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.1111
p.R207C	ACH-001081	Colon/Colorectal Cancer	CCLE	EPGAGVTPA	DEG_SIAH_1	189:197	Mutation rewiring degron network	0.0556
p.R207C	HCC2998	large intestine	COSMIC	VTPAST	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.1111
p.R207C	HCC2998	large intestine	COSMIC	EPGAGVTPA	DEG_SIAH_1	189:197	Mutation rewiring degron network	0.0556
p.H185Y	SIDM01598	Non-Small Cell Lung Carcinoma	GDSC	VTPAST	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.0833
p.H185Y	SIDM01598	Non-Small Cell Lung Carcinoma	GDSC	EPGAGVTPA	DEG_SIAH_1	189:197	Mutation rewiring degron network	0.2222
p.K115E	ACH-000994	Endometrial/Uterine Cancer	CCLE	PPAY	ITCH	124:127	Mutation rewiring degron network	0.0833
p.Y124N	NCI-H378	lung	COSMIC	PPAY	ITCH	124:127	Mutation altering degron motif	0.7059
p.H182N	PANC-10-05	pancreas	COSMIC	EPGAGVTPA	DEG_SIAH_1	189:197	Mutation rewiring degron network	0.1389
p.G132S	NCI-H345	lung	COSMIC	PPAY	ITCH	124:127	Mutation rewiring degron network	0.1944
p.G132S	NCI-H345	lung	COSMIC	PPPY	ITCH	138:141	Mutation rewiring degron network	0.1667
p.R204C	HCC2998	large intestine	COSMIC	VTPAST	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.1944
p.R204C	HCC2998	large intestine	COSMIC	EPGAGVTPA	DEG_SIAH_1	189:197	Mutation rewiring degron network	0.1389
p.C200F	NCI-H835	lung	COSMIC	VTPAST	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.3056
p.C200F	NCI-H835	lung	COSMIC	EPGAGVTPA	DEG_SIAH_1	189:197	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WBP1

UniProt ID: Q96G27

Entrez ID: 23559

Protein name: WW domain-binding protein 1 (WBP-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WBP1 in