DegronMD

Uniprot ID: Q96G27

Source protein: WW domain-binding protein 1

Source gene: WBP1

Class: DEG_SIAH_1

Location: 189:197

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9561

ASA_SCORE: 80.5889

COIL: 0.9416

CONS_SCORE: 0.5379

DSS_SCORE: 0.7178

HELIX: 0.0273

FCONS_SCORE: 0.9189

RIG_SCORE: 0.5624

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G191R	TCGA-AJ-A8CW	UCEC	TCGA	EPGAGVTPA	DEG_SIAH_1	0.6457
p.G191R	DO223583	CLLE	ICGC	EPGAGVTPA	DEG_SIAH_1	0.6457
p.G191R	DO52400	UCEC	ICGC	EPGAGVTPA	DEG_SIAH_1	0.6457
p.R206P	TCGA-KB-A93G	STAD	TCGA	EPGAGVTPA	DEG_SIAH_1	0.0833
p.R206P	DO222335	STAD	ICGC	EPGAGVTPA	DEG_SIAH_1	0.0833
p.P184R	DO223007	ESCA	ICGC	EPGAGVTPA	DEG_SIAH_1	0.1944
p.E187K	DO49683	LIAD	ICGC	EPGAGVTPA	DEG_SIAH_1	0.2778
p.V194G	DO48553	PAEN	ICGC	EPGAGVTPA	DEG_SIAH_1	0.7532
p.S181G	SIDM00120	Prostate Carcinoma	GDSC	EPGAGVTPA	DEG_SIAH_1	0.1111
p.S181G	DU-145	prostate	COSMIC	EPGAGVTPA	DEG_SIAH_1	0.1111
p.P201A	SIDM01112	Osteosarcoma	GDSC	EPGAGVTPA	DEG_SIAH_1	0.2222
p.P201A	SIDM00529	Breast Carcinoma	GDSC	EPGAGVTPA	DEG_SIAH_1	0.2222
p.H185N	SIDM01135	Pancreatic Carcinoma	GDSC	EPGAGVTPA	DEG_SIAH_1	0.2222
p.H185N	SIDM01525	Acute Myeloid Leukemia	GDSC	EPGAGVTPA	DEG_SIAH_1	0.2222
p.H185N	PANC-10-05	pancreas	COSMIC	EPGAGVTPA	DEG_SIAH_1	0.2222
p.C203F	SIDM01133	Other Solid Cancers	GDSC	EPGAGVTPA	DEG_SIAH_1	0.1667
p.C203F	NCI-H835	lung	COSMIC	EPGAGVTPA	DEG_SIAH_1	0.1667
p.R207C	SIDM00118	Colorectal Carcinoma	GDSC	EPGAGVTPA	DEG_SIAH_1	0.0556
p.R207C	ACH-001081	Colon/Colorectal Cancer	CCLE	EPGAGVTPA	DEG_SIAH_1	0.0556
p.R207C	HCC2998	large_intestine	COSMIC	EPGAGVTPA	DEG_SIAH_1	0.0556
p.H185Y	SIDM01598	Non-Small Cell Lung Carcinoma	GDSC	EPGAGVTPA	DEG_SIAH_1	0.2222
p.H182N	PANC-10-05	pancreas	COSMIC	EPGAGVTPA	DEG_SIAH_1	0.1389
p.R204C	HCC2998	large_intestine	COSMIC	EPGAGVTPA	DEG_SIAH_1	0.1389
p.C200F	NCI-H835	lung	COSMIC	EPGAGVTPA	DEG_SIAH_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96G27	WW domain-binding protein 1	DEG_SIAH_1	189:197	EPGAGVTPA	SIAH1,SIAH2,SIAH3	0.9561	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons