DegronMD

Uniprot ID: Q96G27

Source protein: WW domain-binding protein 1

Source gene: WBP1

Class: DEG_SCF_FBW7_1

Location: 194:199

E3 ligase: FBXW7

DEGRON score: 0.9919

ASA_SCORE: 87.05

COIL: 0.9383

CONS_SCORE: 0.4684

DSS_SCORE: 0.6229

HELIX: 0.0315

FCONS_SCORE: 0.7135

RIG_SCORE: 0.6134

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R206P	TCGA-KB-A93G	STAD	TCGA	VTPAST	DEG_SCF_FBW7_1	0.1389
p.R206P	DO222335	STAD	ICGC	VTPAST	DEG_SCF_FBW7_1	0.1389
p.P184R	DO223007	ESCA	ICGC	VTPAST	DEG_SCF_FBW7_1	0.0556
p.E187K	DO49683	LIAD	ICGC	VTPAST	DEG_SCF_FBW7_1	0.1389
p.V194G	DO48553	PAEN	ICGC	VTPAST	DEG_SCF_FBW7_1	0.7532
p.P201A	SIDM01112	Osteosarcoma	GDSC	VTPAST	DEG_SCF_FBW7_1	0.2778
p.P201A	SIDM00529	Breast Carcinoma	GDSC	VTPAST	DEG_SCF_FBW7_1	0.2778
p.H185N	SIDM01135	Pancreatic Carcinoma	GDSC	VTPAST	DEG_SCF_FBW7_1	0.0833
p.H185N	SIDM01525	Acute Myeloid Leukemia	GDSC	VTPAST	DEG_SCF_FBW7_1	0.0833
p.H185N	PANC-10-05	pancreas	COSMIC	VTPAST	DEG_SCF_FBW7_1	0.0833
p.C203F	SIDM01133	Other Solid Cancers	GDSC	VTPAST	DEG_SCF_FBW7_1	0.2222
p.C203F	NCI-H835	lung	COSMIC	VTPAST	DEG_SCF_FBW7_1	0.2222
p.R207C	SIDM00118	Colorectal Carcinoma	GDSC	VTPAST	DEG_SCF_FBW7_1	0.1111
p.R207C	ACH-001081	Colon/Colorectal Cancer	CCLE	VTPAST	DEG_SCF_FBW7_1	0.1111
p.R207C	HCC2998	large_intestine	COSMIC	VTPAST	DEG_SCF_FBW7_1	0.1111
p.H185Y	SIDM01598	Non-Small Cell Lung Carcinoma	GDSC	VTPAST	DEG_SCF_FBW7_1	0.0833
p.R204C	HCC2998	large_intestine	COSMIC	VTPAST	DEG_SCF_FBW7_1	0.1944
p.C200F	NCI-H835	lung	COSMIC	VTPAST	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons