DegronMD - P55196(AFDN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A257T	SIDM02059	Colorectal Carcinoma	GDSC	LRIYAD	LIG_APCC_ABBA_1	250:255	Mutation rewiring degron network	0.2778
p.A257T	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRIYAD	LIG_APCC_ABBA_1	250:255	Mutation rewiring degron network	0.2778
p.A257T	SIDM00104	Mesothelioma	GDSC	LRIYAD	LIG_APCC_ABBA_1	250:255	Mutation rewiring degron network	0.2778
p.A257T	H2369	pleura	COSMIC	LRIYAD	LIG_APCC_ABBA_1	250:255	Mutation rewiring degron network	0.2778
p.A257T	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LRIYAD	LIG_APCC_ABBA_1	250:255	Mutation rewiring degron network	0.2778
p.E1498Q	SIDM02014	Esophageal Carcinoma	GDSC	ERRDLQYIT	DEG_APCC_DBOX_1	1491:1499	Mutation altering degron motif	0.6744
p.D1339N	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	VTPAST	DEG_SCF_FBW7_1	1329:1334	Mutation rewiring degron network	0.1944
p.D1339N	SIDM00673	Breast Carcinoma	GDSC	VTPAST	DEG_SCF_FBW7_1	1329:1334	Mutation rewiring degron network	0.1944
p.M1489I	SIDM00506	Small Cell Lung Carcinoma	GDSC	ERRDLQYIT	DEG_APCC_DBOX_1	1491:1499	Mutation blocking phosphorylation signal	0.7222
p.M1489I	COR-L88	lung	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	1491:1499	Mutation blocking phosphorylation signal	0.7222
p.P263S	SIDM00190	Melanoma	GDSC	LRIYAD	LIG_APCC_ABBA_1	250:255	Mutation blocking phosphorylation signal	0.5556
p.P263S	CP66-MEL	skin	COSMIC	LRIYAD	LIG_APCC_ABBA_1	250:255	Mutation blocking phosphorylation signal	0.5556
p.R1250L	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	KPHMHTD	LIG_APCC_ABBAyCdc20_2	1255:1261	Mutation rewiring degron network	0.1944
p.R1250L	SCC-3	haematopoietic and lymphoid tissue	COSMIC	KPHMHTD	LIG_APCC_ABBAyCdc20_2	1255:1261	Mutation rewiring degron network	0.1944
p.Y1334H	SIDM00487	Colorectal Carcinoma	GDSC	VTPAST	DEG_SCF_FBW7_1	1329:1334	Mutation altering degron motif	0.7229
p.Y1334H	CCK-81	large intestine	COSMIC	VTPAST	DEG_SCF_FBW7_1	1329:1334	Mutation altering degron motif	0.7229
p.M1263T	SIDM00685	Glioblastoma	GDSC	KPHMHTD	LIG_APCC_ABBAyCdc20_2	1255:1261	Mutation rewiring degron network	0.2778
p.M1263T	LN-18	central nervous system	COSMIC	KPHMHTD	LIG_APCC_ABBAyCdc20_2	1255:1261	Mutation rewiring degron network	0.2778
p.R1248W	SIDM00217	Colorectal Carcinoma	GDSC	KPHMHTD	LIG_APCC_ABBAyCdc20_2	1255:1261	Mutation rewiring degron network	0.1389
p.R1248W	SNU-1040	large intestine	COSMIC	KPHMHTD	LIG_APCC_ABBAyCdc20_2	1255:1261	Mutation rewiring degron network	0.1389
p.R258W	SIDM01503	Small Cell Lung Carcinoma	GDSC	LRIYAD	LIG_APCC_ABBA_1	250:255	Mutation substituting flanking lysine	0.3611
p.S1268N	SIDM01608	Endometrial Carcinoma	GDSC	KPHMHTD	LIG_APCC_ABBAyCdc20_2	1255:1261	Mutation rewiring degron network	0.1389
p.V1332A	CCK-81	large intestine	COSMIC	VTPAST	DEG_SCF_FBW7_1	1329:1334	Mutation altering degron motif	0.6936
p.S1506F	SW684	soft tissue	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	1491:1499	Mutation blocking phosphorylation signal	0.5833
p.S1506F	K2	skin	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	1491:1499	Mutation blocking phosphorylation signal	0.5833
p.S1489F	K2	skin	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	1491:1499	Mutation blocking phosphorylation signal	0.7222
p.S1489F	SW684	soft tissue	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	1491:1499	Mutation blocking phosphorylation signal	0.7222
p.R1487C	T84	large intestine	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	1491:1499	Mutation rewiring degron network	0.2222
p.S1332T	NCI-H630	large intestine	COSMIC	VTPAST	DEG_SCF_FBW7_1	1329:1334	Mutation altering degron motif	0.7116
p.S1324T	NCI-H630	large intestine	COSMIC	VTPAST	DEG_SCF_FBW7_1	1329:1334	Mutation rewiring degron network	0.1944
p.S1505F	K2	skin	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	1491:1499	Mutation rewiring degron network	0.1667
p.S1505F	SW684	soft tissue	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	1491:1499	Mutation rewiring degron network	0.1667
p.S1509C	SNU-C5	large intestine	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	1491:1499	Mutation rewiring degron network	0.0556
p.E1487D	CW-2	large intestine	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	1491:1499	Mutation rewiring degron network	0.2222
p.Y1504C	LNCaP-Clone-FGC	prostate	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	1491:1499	Mutation rewiring degron network	0.1944
p.R1495C	T84	large intestine	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	1491:1499	Mutation altering degron motif	0.8301
p.S1493C	SNU-C5	large intestine	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	1491:1499	Mutation altering degron motif	0.7541
p.R1488C	T84	large intestine	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	1491:1499	Mutation rewiring degron network	0.25
p.S1325T	NCI-H630	large intestine	COSMIC	VTPAST	DEG_SCF_FBW7_1	1329:1334	Mutation rewiring degron network	0.2222
p.Y1497C	LNCaP-Clone-FGC	prostate	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	1491:1499	Mutation altering degron motif	0.7087
p.A1330T	SNU-1040	large intestine	COSMIC	VTPAST	DEG_SCF_FBW7_1	1329:1334	Mutation altering degron motif	0.7139
p.M1249I	HL-60	haematopoietic and lymphoid tissue	COSMIC	KPHMHTD	LIG_APCC_ABBAyCdc20_2	1255:1261	Mutation rewiring degron network	0.1667
p.L246V	CMK	haematopoietic and lymphoid tissue	COSMIC	LRIYAD	LIG_APCC_ABBA_1	250:255	Mutation blocking phosphorylation signal	0.6667
p.Y1496C	LNCaP-Clone-FGC	prostate	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	1491:1499	Mutation altering degron motif	0.7087

Kaplan plot for AFDN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AFDN

UniProt ID: P55196

Entrez ID: 4301

Protein name: Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AFDN in