DegronMD

Uniprot ID: P55196

Source protein: Afadin

Source gene: AFDN

Class: DEG_APCC_DBOX_1

Location: 1491:1499

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8549

ASA_SCORE: 105.9222

COIL: 0.5484

CONS_SCORE: 0.3076

DSS_SCORE: 0.5343

HELIX: 0.4311

FCONS_SCORE: 0.9652

RIG_SCORE: 0.7935

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1498Q	SIDM02014	Esophageal Carcinoma	GDSC	ERRDLQYIT	DEG_APCC_DBOX_1	0.6744
p.M1489I	SIDM00506	Small Cell Lung Carcinoma	GDSC	ERRDLQYIT	DEG_APCC_DBOX_1	0.7222
p.M1489I	COR-L88	lung	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	0.7222
p.S1506F	SW684	soft_tissue	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	0.5833
p.S1506F	K2	skin	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	0.5833
p.S1489F	K2	skin	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	0.7222
p.S1489F	SW684	soft_tissue	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	0.7222
p.R1487C	T84	large_intestine	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	0.2222
p.S1505F	K2	skin	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	0.1667
p.S1505F	SW684	soft_tissue	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	0.1667
p.S1509C	SNU-C5	large_intestine	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	0.0556
p.E1487D	CW-2	large_intestine	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	0.2222
p.Y1504C	LNCaP-Clone-FGC	prostate	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	0.1944
p.R1495C	T84	large_intestine	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	0.8301
p.S1493C	SNU-C5	large_intestine	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	0.7541
p.R1488C	T84	large_intestine	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	0.25
p.Y1497C	LNCaP-Clone-FGC	prostate	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	0.7087
p.Y1496C	LNCaP-Clone-FGC	prostate	COSMIC	ERRDLQYIT	DEG_APCC_DBOX_1	0.7087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55196	Afadin	DEG_APCC_DBOX_1	1491:1499	ERRDLQYIT	APC,CDC20,FZR1	0.8549	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons