DegronMD

Uniprot ID: P55196

Source protein: Afadin

Source gene: AFDN

Class: LIG_APCC_ABBAyCdc20_2

Location: 1255:1261

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9726

ASA_SCORE: 111.7

COIL: 0.9433

CONS_SCORE: 0.2549

DSS_SCORE: 0.6864

HELIX: 0.0407

FCONS_SCORE: 0.8952

RIG_SCORE: 0.6059

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1250L	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	KPHMHTD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R1250L	SCC-3	haematopoietic_and_lymphoid_tissue	COSMIC	KPHMHTD	LIG_APCC_ABBAyCdc20_2	0.1944
p.M1263T	SIDM00685	Glioblastoma	GDSC	KPHMHTD	LIG_APCC_ABBAyCdc20_2	0.2778
p.M1263T	LN-18	central_nervous_system	COSMIC	KPHMHTD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R1248W	SIDM00217	Colorectal Carcinoma	GDSC	KPHMHTD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R1248W	SNU-1040	large_intestine	COSMIC	KPHMHTD	LIG_APCC_ABBAyCdc20_2	0.1389
p.S1268N	SIDM01608	Endometrial Carcinoma	GDSC	KPHMHTD	LIG_APCC_ABBAyCdc20_2	0.1389
p.M1249I	HL-60	haematopoietic_and_lymphoid_tissue	COSMIC	KPHMHTD	LIG_APCC_ABBAyCdc20_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55196	Afadin	LIG_APCC_ABBAyCdc20_2	1255:1261	KPHMHTD	APC,CDC20,FZR1	0.9726	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons