DegronMD

Uniprot ID: P55196

Source protein: Afadin

Source gene: AFDN

Class: DEG_SCF_FBW7_1

Location: 1329:1334

E3 ligase: FBXW7

DEGRON score: 0.9943

ASA_SCORE: 95.8

COIL: 0.9578

CONS_SCORE: 0.2509

DSS_SCORE: 0.6177

HELIX: 0.0283

FCONS_SCORE: 0.8534

RIG_SCORE: 0.6305

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1339N	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	VTPAST	DEG_SCF_FBW7_1	0.1944
p.D1339N	SIDM00673	Breast Carcinoma	GDSC	VTPAST	DEG_SCF_FBW7_1	0.1944
p.Y1334H	SIDM00487	Colorectal Carcinoma	GDSC	VTPAST	DEG_SCF_FBW7_1	0.7229
p.Y1334H	CCK-81	large_intestine	COSMIC	VTPAST	DEG_SCF_FBW7_1	0.7229
p.V1332A	CCK-81	large_intestine	COSMIC	VTPAST	DEG_SCF_FBW7_1	0.6936
p.S1332T	NCI-H630	large_intestine	COSMIC	VTPAST	DEG_SCF_FBW7_1	0.7116
p.S1324T	NCI-H630	large_intestine	COSMIC	VTPAST	DEG_SCF_FBW7_1	0.1944
p.S1325T	NCI-H630	large_intestine	COSMIC	VTPAST	DEG_SCF_FBW7_1	0.2222
p.A1330T	SNU-1040	large_intestine	COSMIC	VTPAST	DEG_SCF_FBW7_1	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons