DegronMD

Uniprot ID: P55196

Source protein: Afadin

Source gene: AFDN

Class: LIG_APCC_ABBA_1

Location: 250:255

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5208

ASA_SCORE: 37.5667

COIL: 0.2193

CONS_SCORE: 0.5602

DSS_SCORE: 0.4578

HELIX: 0.2062

FCONS_SCORE: 1.1336

RIG_SCORE: 0.8001

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A257T	SIDM02059	Colorectal Carcinoma	GDSC	LRIYAD	LIG_APCC_ABBA_1	0.2778
p.A257T	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRIYAD	LIG_APCC_ABBA_1	0.2778
p.A257T	SIDM00104	Mesothelioma	GDSC	LRIYAD	LIG_APCC_ABBA_1	0.2778
p.A257T	H2369	pleura	COSMIC	LRIYAD	LIG_APCC_ABBA_1	0.2778
p.A257T	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LRIYAD	LIG_APCC_ABBA_1	0.2778
p.P263S	SIDM00190	Melanoma	GDSC	LRIYAD	LIG_APCC_ABBA_1	0.5556
p.P263S	CP66-MEL	skin	COSMIC	LRIYAD	LIG_APCC_ABBA_1	0.5556
p.R258W	SIDM01503	Small Cell Lung Carcinoma	GDSC	LRIYAD	LIG_APCC_ABBA_1	0.3611
p.L246V	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	LRIYAD	LIG_APCC_ABBA_1	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55196	Afadin	LIG_APCC_ABBA_1	250:255	LRIYAD	APC,CDC20,FZR1	0.5208	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons