DegronMD

Uniprot ID: Q9NRM7

Source protein: Serine/threonine-protein kinase LATS2

Source gene: LATS2

Class: ITCH

Location: 515:518

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9941

ASA_SCORE: 87.8

COIL: 0.9758

CONS_SCORE: 0.3969

DSS_SCORE: 0.5325

HELIX: 0.011

FCONS_SCORE: 1.1964

RIG_SCORE: 0.6642

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P516L	TCGA-18-3409	LUSC	TCGA	PPPY	ITCH	0.7582
p.P516L	DO26444	LUSC	ICGC	PPPY	ITCH	0.7582
p.P516L	ACH-000950	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	0.7582
p.P516S	DO228260	BRCA	ICGC	PPPY	ITCH	0.6752
p.S528L	TCGA-2W-A8YY	CESC	TCGA	PPPY	ITCH	0.5
p.S528L	TCGA-46-3769	LUSC	TCGA	PPPY	ITCH	0.5
p.S528L	DO223732	CESC	ICGC	PPPY	ITCH	0.5
p.S528L	DO26590	LUSC	ICGC	PPPY	ITCH	0.5
p.P514T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	0.3056
p.P514T	ACH-002256	Leukemia	CCLE	PPPY	ITCH	0.3056
p.P514T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PPPY	ITCH	0.3056
p.R512S	DO44666	LICA	ICGC	PPPY	ITCH	0.25
p.R511W	DO44086	COAD	ICGC	PPPY	ITCH	0.2222
p.P509S	TCGA-B0-4810	KIRC	TCGA	PPPY	ITCH	0.1667
p.P509S	DO17643	KIRC	ICGC	PPPY	ITCH	0.1667
p.R525C	TCGA-BT-A20J	BLCA	TCGA	PPPY	ITCH	0.1389
p.R525C	DO457	BLCA	ICGC	PPPY	ITCH	0.1389
p.R525C	SIDM00216	Colorectal Carcinoma	GDSC	PPPY	ITCH	0.1389
p.R525C	SIDM01146	Gastric Carcinoma	GDSC	PPPY	ITCH	0.1389
p.R525C	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	0.1389
p.R525C	ACH-000932	Gastric Cancer	CCLE	PPPY	ITCH	0.1389
p.R525C	ACH-000942	Leukemia	CCLE	PPPY	ITCH	0.1389
p.R525C	ACH-000989	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	0.1389
p.R525C	SNU-175	large_intestine	COSMIC	PPPY	ITCH	0.1389
p.R525C	NCI-SNU-1	stomach	COSMIC	PPPY	ITCH	0.1389

Showing 1 to 25 of 36 entries

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Drug responses associated with LATS2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPPY

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96DV4	39S ribosomal protein L38, mitochondrial	ITCH	347:350	PPPY	ITCH,NEDD4	0.6466	More...
O15072	A disintegrin and metalloproteinase with thrombospondin motifs 3	ITCH	1058:1061	PPPY	ITCH,NEDD4	0.9797	More...
Q13625	Apoptosis-stimulating of p53 protein 2	ITCH	871:874	PPPY	ITCH,NEDD4	0.9885	More...
P54259	Atrophin-1	ITCH	445:448	PPPY	ITCH,NEDD4	0.973	More...
P54259	Atrophin-1	ITCH	636:639	PPPY	ITCH,NEDD4	0.9909	More...
Q8WXX7	Autism susceptibility gene 2 protein	ITCH	516:519	PPPY	ITCH,NEDD4	0.9979	More...
O00512	B-cell CLL/lymphoma 9 protein	ITCH	515:518	PPPY	ITCH,NEDD4	0.9973	More...
Q86UU0	B-cell CLL/lymphoma 9-like protein	ITCH	561:564	PPPY	ITCH,NEDD4	0.9923	More...
O95395	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3	ITCH	285:288	PPPY	ITCH,NEDD4	0.5532	More...
O95415	Brain protein I3	ITCH	39:42	PPPY	ITCH,NEDD4	0.9496	More...
Q15018	BRISC complex subunit Abraxas 2	ITCH	305:308	PPPY	ITCH,NEDD4	0.9939	More...
Q9P203	BTB/POZ domain-containing protein 7	ITCH	762:765	PPPY	ITCH,NEDD4	0.9575	More...
Q9Y6W3	Calpain-7	ITCH	624:627	PPPY	ITCH,NEDD4	0.5393	More...
Q8WXE0	Caskin-2	ITCH	751:754	PPPY	ITCH,NEDD4	0.6879	More...
Q9H305	Cell death-inducing p53-target protein 1	ITCH	6:9	PPPY	ITCH,NEDD4	0.9945	More...
Q9H305	Cell death-inducing p53-target protein 1	ITCH	51:54	PPPY	ITCH,NEDD4	0.9943	More...
Q16630	Cleavage and polyadenylation specificity factor subunit 6	ITCH	387:390	PPPY	ITCH,NEDD4	0.9919	More...
Q8WXI2	Connector enhancer of kinase suppressor of ras 2	ITCH	704:707	PPPY	ITCH,NEDD4	0.9478	More...
Q86YQ8	Copine-8	ITCH	550:553	PPPY	ITCH,NEDD4	0.743	More...
Q6UUV7	CREB-regulated transcription coactivator 3	ITCH	445:448	PPPY	ITCH,NEDD4	0.998	More...
Q96J86	Cysteine and tyrosine-rich protein 1	ITCH	113:116	PPPY	ITCH,NEDD4	0.9396	More...
Q96J86	Cysteine and tyrosine-rich protein 1	ITCH	129:132	PPPY	ITCH,NEDD4	0.9428	More...
Q96J86	Cysteine and tyrosine-rich protein 1	ITCH	145:148	PPPY	ITCH,NEDD4	0.9794	More...
Q9H1C7	Cysteine-rich and transmembrane domain-containing protein 1	ITCH	6:9	PPPY	ITCH,NEDD4	0.9391	More...
Q9BTC0	Death-inducer obliterator 1	ITCH	1817:1820	PPPY	ITCH,NEDD4	0.9967	More...

Showing 1 to 25 of 180 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPPY

Degron related mutations and impact score

Drug responses associated with LATS2 mutations

All proteins holding degron of PPPY