DegronMD - Q86UU0(BCL9L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R994M	TCGA-21-1082	LUSC	TCGA	SPSMAVPSP	DEG_COP1_1	997:1005	Mutation rewiring degron network	0.25
p.R994M	DO26463	LUSC	ICGC	SPSMAVPSP	DEG_COP1_1	997:1005	Mutation rewiring degron network	0.25
p.H565R	TCGA-77-7465	LUSC	TCGA	PPPY	ITCH	561:564	Mutation rewiring degron network	0.3056
p.H565R	DO27699	LUSC	ICGC	PPPY	ITCH	561:564	Mutation rewiring degron network	0.3056
p.A99V	TCGA-A2-A4S2	BRCA	TCGA	NPQAGVPPF	DEG_SIAH_1	96:104	Mutation altering degron motif	0.6936
p.A99V	DO44184	BRCA	ICGC	NPQAGVPPF	DEG_SIAH_1	96:104	Mutation altering degron motif	0.6936
p.P998H	TCGA-A5-A0G2	UCEC	TCGA	SPSMAVPSP	DEG_COP1_1	997:1005	Mutation altering degron motif	0.6583
p.P998H	DO41235	UCEC	ICGC	SPSMAVPSP	DEG_COP1_1	997:1005	Mutation altering degron motif	0.6583
p.P356L	TCGA-AA-A01R	COAD	TCGA	PNTPTAT	DEG_SCF_FBW7_1	353:359	Mutation altering degron motif	0.7582
p.P356L	DO7934	COAD	ICGC	PNTPTAT	DEG_SCF_FBW7_1	353:359	Mutation altering degron motif	0.7582
p.S1222F	TCGA-AD-6964	COAD	TCGA	VPSSS	DEG_SPOP_SBC_1	1219:1223	Mutation altering degron motif	0.7982
p.S1222F	TCGA-EE-A2GO	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	1219:1223	Mutation altering degron motif	0.7982
p.S1222F	DO8360	COAD	ICGC	VPSSS	DEG_SPOP_SBC_1	1219:1223	Mutation altering degron motif	0.7982
p.S1222F	DO37823	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	1219:1223	Mutation altering degron motif	0.7982
p.M1065I	TCGA-AP-A1DK	UCEC	TCGA	PFTSS	DEG_SPOP_SBC_1	1070:1074	Mutation rewiring degron network	0.1944
p.M1065I	DO42033	UCEC	ICGC	PFTSS	DEG_SPOP_SBC_1	1070:1074	Mutation rewiring degron network	0.1944
p.P1056L	TCGA-BA-A6DJ	HNSC	TCGA	PRSSS	DEG_SPOP_SBC_1	1049:1053	Mutation rewiring degron network	0.25
p.P1056L	DO52034	HNSC	ICGC	PRSSS	DEG_SPOP_SBC_1	1049:1053	Mutation rewiring degron network	0.25
p.G109S	TCGA-BH-A1FL	BRCA	TCGA	SVDSGE	DEG_Kelch_Keap1_1	118:123	Mutation rewiring degron network	0.0833
p.G109S	TCGA-BH-A1FL	BRCA	TCGA	NPQAGVPPF	DEG_SIAH_1	96:104	Mutation rewiring degron network	0.1944
p.G109S	DO5221	BRCA	ICGC	SVDSGE	DEG_Kelch_Keap1_1	118:123	Mutation rewiring degron network	0.0833
p.G109S	DO5221	BRCA	ICGC	NPQAGVPPF	DEG_SIAH_1	96:104	Mutation rewiring degron network	0.1944
p.T1043A	TCGA-BR-4361	STAD	TCGA	PRSSS	DEG_SPOP_SBC_1	1049:1053	Mutation rewiring degron network	0.1667
p.M1039L	TCGA-CG-5726	STAD	TCGA	PRSSS	DEG_SPOP_SBC_1	1049:1053	Mutation rewiring degron network	0.0556
p.M1039L	DO38483	STAD	ICGC	PRSSS	DEG_SPOP_SBC_1	1049:1053	Mutation rewiring degron network	0.0556
p.P130S	TCGA-CN-5355	HNSC	TCGA	SVDSGE	DEG_Kelch_Keap1_1	118:123	Mutation rewiring degron network	0.1389
p.P130S	DO14638	HNSC	ICGC	SVDSGE	DEG_Kelch_Keap1_1	118:123	Mutation rewiring degron network	0.1389
p.G1042C	TCGA-D3-A2JL	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	1049:1053	Mutation rewiring degron network	0.1389
p.P1045L	TCGA-ER-A193	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	1049:1053	Mutation rewiring degron network	0.2222
p.P1045L	TCGA-IB-7651	PAAD	TCGA	PRSSS	DEG_SPOP_SBC_1	1049:1053	Mutation rewiring degron network	0.2222
p.P1045L	DO46657	PAAD	ICGC	PRSSS	DEG_SPOP_SBC_1	1049:1053	Mutation rewiring degron network	0.2222
p.P1045L	DO47368	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	1049:1053	Mutation rewiring degron network	0.2222
p.A1001V	TCGA-EY-A549	UCEC	TCGA	SPSMAVPSP	DEG_COP1_1	997:1005	Mutation altering degron motif	0.5825
p.A1001V	TCGA-XK-AAIW	PRAD	TCGA	SPSMAVPSP	DEG_COP1_1	997:1005	Mutation altering degron motif	0.5825
p.A1001V	DO51407	PRAD	ICGC	SPSMAVPSP	DEG_COP1_1	997:1005	Mutation altering degron motif	0.5825
p.A1001V	DO48174	UCEC	ICGC	SPSMAVPSP	DEG_COP1_1	997:1005	Mutation altering degron motif	0.5825
p.A1001V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	SPSMAVPSP	DEG_COP1_1	997:1005	Mutation altering degron motif	0.5825
p.A1001V	SIDM00980	Gastric Carcinoma	GDSC	SPSMAVPSP	DEG_COP1_1	997:1005	Mutation altering degron motif	0.5825
p.A1001V	ACH-000948	Gastric Cancer	CCLE	SPSMAVPSP	DEG_COP1_1	997:1005	Mutation altering degron motif	0.5825
p.A1001V	ACH-001127	Leukemia	CCLE	SPSMAVPSP	DEG_COP1_1	997:1005	Mutation altering degron motif	0.5825
p.A1001V	23132-87	stomach	COSMIC	SPSMAVPSP	DEG_COP1_1	997:1005	Mutation altering degron motif	0.5825
p.A1001V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	SPSMAVPSP	DEG_COP1_1	997:1005	Mutation altering degron motif	0.5825
p.S991L	TCGA-FS-A4F5	SKCM	TCGA	SPSMAVPSP	DEG_COP1_1	997:1005	Mutation blocking phosphorylation signal	0.6111
p.S991L	DO37881	SKCM	ICGC	SPSMAVPSP	DEG_COP1_1	997:1005	Mutation blocking phosphorylation signal	0.6111
p.Q98R	TCGA-GC-A3YS	BLCA	TCGA	NPQAGVPPF	DEG_SIAH_1	96:104	Mutation altering degron motif	0.6218
p.Q98R	DO850	BLCA	ICGC	NPQAGVPPF	DEG_SIAH_1	96:104	Mutation altering degron motif	0.6218
p.C1216R	TCGA-HU-A4GT	STAD	TCGA	VPSSS	DEG_SPOP_SBC_1	1219:1223	Mutation rewiring degron network	0.25
p.C1216R	DO48020	STAD	ICGC	VPSSS	DEG_SPOP_SBC_1	1219:1223	Mutation rewiring degron network	0.25
p.P103H	TCGA-L5-A43J	ESCA	TCGA	NPQAGVPPF	DEG_SIAH_1	96:104	Mutation altering degron motif	0.7694
p.R125Q	TCGA-MX-A5UJ	STAD	TCGA	SVDSGE	DEG_Kelch_Keap1_1	118:123	Mutation rewiring degron network	0.2778
p.R125Q	DO48547	STAD	ICGC	SVDSGE	DEG_Kelch_Keap1_1	118:123	Mutation rewiring degron network	0.2778
p.A361T	TCGA-VQ-A8PB	STAD	TCGA	PNTPTAT	DEG_SCF_FBW7_1	353:359	Mutation rewiring degron network	0.2778
p.A361T	DO51766	STAD	ICGC	PNTPTAT	DEG_SCF_FBW7_1	353:359	Mutation rewiring degron network	0.2778
p.P1075S	TCGA-XK-AAIW	PRAD	TCGA	PFTSS	DEG_SPOP_SBC_1	1070:1074	Mutation rewiring degron network	0.3056
p.P1075S	DO51407	PRAD	ICGC	PFTSS	DEG_SPOP_SBC_1	1070:1074	Mutation rewiring degron network	0.3056
p.S1053P	DO222404	BTCA	ICGC	PRSSS	DEG_SPOP_SBC_1	1049:1053	Mutation altering degron motif	0.6752
p.G1063D	DO227987	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	1049:1053	Mutation rewiring degron network	0.0556
p.G1063D	DO227987	COCA	ICGC	PFTSS	DEG_SPOP_SBC_1	1070:1074	Mutation rewiring degron network	0.1389
p.P1075Q	DO234197	ESAD	ICGC	PFTSS	DEG_SPOP_SBC_1	1070:1074	Mutation rewiring degron network	0.3056
p.L94V	DO222489	ESCA	ICGC	NPQAGVPPF	DEG_SIAH_1	96:104	Mutation rewiring degron network	0.2778
p.G1006S	DO233216	GACA	ICGC	SPSMAVPSP	DEG_COP1_1	997:1005	Mutation rewiring degron network	0.3056
p.P1171L	DO233888	GACA	ICGC	PSPTPLGS	DEG_SCF_FBW7_1	1176:1183	Mutation rewiring degron network	0.1944
p.N96S	DO233867	GACA	ICGC	NPQAGVPPF	DEG_SIAH_1	96:104	Mutation altering degron motif	0.5958
p.K567T	DO233951	GACA	ICGC	PPPY	ITCH	561:564	Mutation substituting flanking lysine	0.3611
p.P1083T	DO228974	LICA	ICGC	PFTSS	DEG_SPOP_SBC_1	1070:1074	Mutation rewiring degron network	0.0833
p.Q124K	DO229028	LICA	ICGC	SVDSGE	DEG_Kelch_Keap1_1	118:123	Mutation rewiring degron network	0.3056
p.P574T	DO229027	LICA	ICGC	PPPY	ITCH	561:564	Mutation rewiring degron network	0.0556
p.P102T	DO229026	LICA	ICGC	NPQAGVPPF	DEG_SIAH_1	96:104	Mutation altering degron motif	0.5919
p.S118Y	DO229035	LICA	ICGC	SVDSGE	DEG_Kelch_Keap1_1	118:123	Mutation altering degron motif	0.8231
p.P1011T	DO229037	LICA	ICGC	SPSMAVPSP	DEG_COP1_1	997:1005	Mutation rewiring degron network	0.1667
p.P1075L	DO229058	LICA	ICGC	PFTSS	DEG_SPOP_SBC_1	1070:1074	Mutation rewiring degron network	0.3056
p.N1082K	DO229006	LICA	ICGC	PFTSS	DEG_SPOP_SBC_1	1070:1074	Mutation rewiring degron network	0.1111
p.P1172T	DO229009	LICA	ICGC	PSPTPLGS	DEG_SCF_FBW7_1	1176:1183	Mutation rewiring degron network	0.2222
p.D120E	DO229008	LICA	ICGC	SVDSGE	DEG_Kelch_Keap1_1	118:123	Mutation altering degron motif	0.5647
p.G349R	DO50743	LICA	ICGC	PNTPTAT	DEG_SCF_FBW7_1	353:359	Mutation rewiring degron network	0.2222
p.P1178L	DO222662	MELA	ICGC	PSPTPLGS	DEG_SCF_FBW7_1	1176:1183	Mutation altering degron motif	0.6471
p.S1073F	DO222662	MELA	ICGC	PFTSS	DEG_SPOP_SBC_1	1070:1074	Mutation altering degron motif	0.7982
p.G109D	DO35406	PACA	ICGC	SVDSGE	DEG_Kelch_Keap1_1	118:123	Mutation rewiring degron network	0.0833
p.G109D	DO35406	PACA	ICGC	NPQAGVPPF	DEG_SIAH_1	96:104	Mutation rewiring degron network	0.1944
p.M1174V	DO228741	PRAD	ICGC	PSPTPLGS	DEG_SCF_FBW7_1	1176:1183	Mutation rewiring degron network	0.2778
p.P561L	DO38404	STAD	ICGC	PPPY	ITCH	561:564	Mutation altering degron motif	0.7582
p.P1045S	DO229253	THCA	ICGC	PRSSS	DEG_SPOP_SBC_1	1049:1053	Mutation rewiring degron network	0.2222
p.T1179P	DO229253	THCA	ICGC	PSPTPLGS	DEG_SCF_FBW7_1	1176:1183	Mutation altering degron motif	0.7031
p.T1179P	DO229245	THCA	ICGC	PSPTPLGS	DEG_SCF_FBW7_1	1176:1183	Mutation altering degron motif	0.7031
p.S1222P	DO229216	THCA	ICGC	VPSSS	DEG_SPOP_SBC_1	1219:1223	Mutation altering degron motif	0.6752
p.G1048V	DO229211	THCA	ICGC	PRSSS	DEG_SPOP_SBC_1	1049:1053	Mutation rewiring degron network	0.3056
p.P1077R	SIDM00915	Small Cell Lung Carcinoma	GDSC	PFTSS	DEG_SPOP_SBC_1	1070:1074	Mutation rewiring degron network	0.25
p.P1077R	SIDM00719	Small Cell Lung Carcinoma	GDSC	PFTSS	DEG_SPOP_SBC_1	1070:1074	Mutation rewiring degron network	0.25
p.P1077R	NCI-H378	lung	COSMIC	PFTSS	DEG_SPOP_SBC_1	1070:1074	Mutation rewiring degron network	0.25
p.P1077R	NCI-H345	lung	COSMIC	PFTSS	DEG_SPOP_SBC_1	1070:1074	Mutation rewiring degron network	0.25
p.P1230L	SIDM00434	Plasma Cell Myeloma	GDSC	VPSSS	DEG_SPOP_SBC_1	1219:1223	Mutation rewiring degron network	0.1389
p.P1230L	ACH-000745	Myeloma	CCLE	VPSSS	DEG_SPOP_SBC_1	1219:1223	Mutation rewiring degron network	0.1389
p.R1050W	SIDM00660	Colorectal Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	1049:1053	Mutation altering degron motif	0.7523
p.R1050W	ACH-000985	Colon/Colorectal Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	1049:1053	Mutation altering degron motif	0.7523
p.R1050W	LS-411N	large intestine	COSMIC	PRSSS	DEG_SPOP_SBC_1	1049:1053	Mutation altering degron motif	0.7523
p.G554S	SIDM00589	Oral Cavity Carcinoma	GDSC	PPPY	ITCH	561:564	Mutation rewiring degron network	0.1389
p.G554S	ACH-000778	Head and Neck Cancer	CCLE	PPPY	ITCH	561:564	Mutation rewiring degron network	0.1389
p.G554S	HSC-3	upper aerodigestive tract	COSMIC	PPPY	ITCH	561:564	Mutation rewiring degron network	0.1389
p.P97L	SIDM00177	Melanoma	GDSC	NPQAGVPPF	DEG_SIAH_1	96:104	Mutation altering degron motif	0.7582
p.S566I	SIDM00653	Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	561:564	Mutation rewiring degron network	0.2778
p.S566I	ACH-000514	Lung Cancer	CCLE	PPPY	ITCH	561:564	Mutation rewiring degron network	0.2778
p.S566I	NCI-H1092	lung	COSMIC	PPPY	ITCH	561:564	Mutation rewiring degron network	0.2778
p.A1009V	SIDM00999	Bladder Carcinoma	GDSC	SPSMAVPSP	DEG_COP1_1	997:1005	Mutation rewiring degron network	0.2222
p.A1009V	ACH-000973	Bladder Cancer	CCLE	SPSMAVPSP	DEG_COP1_1	997:1005	Mutation rewiring degron network	0.2222
p.A1009V	639-V	urinary tract	COSMIC	SPSMAVPSP	DEG_COP1_1	997:1005	Mutation rewiring degron network	0.2222
p.G553W	SIDM00150	Colorectal Carcinoma	GDSC	PPPY	ITCH	561:564	Mutation rewiring degron network	0.1111
p.G553W	ACH-000969	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	561:564	Mutation rewiring degron network	0.1111
p.G553W	KM12	large intestine	COSMIC	PPPY	ITCH	561:564	Mutation rewiring degron network	0.1111
p.A1055T	SIDM01608	Endometrial Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	1049:1053	Mutation rewiring degron network	0.2778
p.A1055T	ACH-000990	Endometrial/Uterine Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	1049:1053	Mutation rewiring degron network	0.2778
p.P1082L	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PFTSS	DEG_SPOP_SBC_1	1070:1074	Mutation rewiring degron network	0.1111
p.L112V	SK-GT-4	oesophagus	COSMIC	SVDSGE	DEG_Kelch_Keap1_1	118:123	Mutation substituting flanking lysine	0.2778
p.L112V	SK-GT-4	oesophagus	COSMIC	NPQAGVPPF	DEG_SIAH_1	96:104	Mutation substituting flanking lysine	0.2222
p.P567S	SH-4	skin	COSMIC	PPPY	ITCH	561:564	Mutation substituting flanking lysine	0.3611
p.P1040R	NCI-H378	lung	COSMIC	PRSSS	DEG_SPOP_SBC_1	1049:1053	Mutation rewiring degron network	0.0833
p.P1040R	NCI-H345	lung	COSMIC	PRSSS	DEG_SPOP_SBC_1	1049:1053	Mutation rewiring degron network	0.0833
p.R109C	SNU-1040	large intestine	COSMIC	SVDSGE	DEG_Kelch_Keap1_1	118:123	Mutation rewiring degron network	0.0833
p.R109C	SNU-1040	large intestine	COSMIC	NPQAGVPPF	DEG_SIAH_1	96:104	Mutation rewiring degron network	0.1944
p.R1013W	LS-411N	large intestine	COSMIC	SPSMAVPSP	DEG_COP1_1	997:1005	Mutation blocking phosphorylation signal	0.5556
p.T997N	JAR	placenta	COSMIC	SPSMAVPSP	DEG_COP1_1	997:1005	Mutation altering degron motif	0.7055
p.A1074T	LS-411N	large intestine	COSMIC	PFTSS	DEG_SPOP_SBC_1	1070:1074	Mutation altering degron motif	0.7139
p.A1074S	DMS-53	lung	COSMIC	PFTSS	DEG_SPOP_SBC_1	1070:1074	Mutation altering degron motif	0.7588
p.P1082S	TOV-21G	ovary	COSMIC	PFTSS	DEG_SPOP_SBC_1	1070:1074	Mutation rewiring degron network	0.1111
p.R114P	NCI-H1299	lung	COSMIC	SVDSGE	DEG_Kelch_Keap1_1	118:123	Mutation rewiring degron network	0.2222
p.R114P	NCI-H1299	lung	COSMIC	NPQAGVPPF	DEG_SIAH_1	96:104	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BCL9L

UniProt ID: Q86UU0

Entrez ID: 283149

Protein name: B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BCL9L in