DegronMD

Uniprot ID: Q86UU0

Source protein: B-cell CLL/lymphoma 9-like protein

Source gene: BCL9L

Class: DEG_SPOP_SBC_1

Location: 1070:1074

E3 ligase: SPOP

DEGRON score: 0.9837

ASA_SCORE: 97.74

COIL: 0.9738

CONS_SCORE: 0.9399

DSS_SCORE: 0.7274

HELIX: 0.0114

FCONS_SCORE: 1.2167

RIG_SCORE: 0.5662

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1073F	DO222662	MELA	ICGC	PFTSS	DEG_SPOP_SBC_1	0.7982
p.A1074S	DMS-53	lung	COSMIC	PFTSS	DEG_SPOP_SBC_1	0.7588
p.A1074T	LS-411N	large_intestine	COSMIC	PFTSS	DEG_SPOP_SBC_1	0.7139
p.P1075S	TCGA-XK-AAIW	PRAD	TCGA	PFTSS	DEG_SPOP_SBC_1	0.3056
p.P1075S	DO51407	PRAD	ICGC	PFTSS	DEG_SPOP_SBC_1	0.3056
p.P1075Q	DO234197	ESAD	ICGC	PFTSS	DEG_SPOP_SBC_1	0.3056
p.P1075L	DO229058	LICA	ICGC	PFTSS	DEG_SPOP_SBC_1	0.3056
p.P1077R	SIDM00915	Small Cell Lung Carcinoma	GDSC	PFTSS	DEG_SPOP_SBC_1	0.25
p.P1077R	SIDM00719	Small Cell Lung Carcinoma	GDSC	PFTSS	DEG_SPOP_SBC_1	0.25
p.P1077R	NCI-H378	lung	COSMIC	PFTSS	DEG_SPOP_SBC_1	0.25
p.P1077R	NCI-H345	lung	COSMIC	PFTSS	DEG_SPOP_SBC_1	0.25
p.M1065I	TCGA-AP-A1DK	UCEC	TCGA	PFTSS	DEG_SPOP_SBC_1	0.1944
p.M1065I	DO42033	UCEC	ICGC	PFTSS	DEG_SPOP_SBC_1	0.1944
p.G1063D	DO227987	COCA	ICGC	PFTSS	DEG_SPOP_SBC_1	0.1389
p.N1082K	DO229006	LICA	ICGC	PFTSS	DEG_SPOP_SBC_1	0.1111
p.P1082L	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PFTSS	DEG_SPOP_SBC_1	0.1111
p.P1082S	TOV-21G	ovary	COSMIC	PFTSS	DEG_SPOP_SBC_1	0.1111
p.P1083T	DO228974	LICA	ICGC	PFTSS	DEG_SPOP_SBC_1	0.0833

Showing 1 to 18 of 18 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UU0	B-cell CLL/lymphoma 9-like protein	DEG_SPOP_SBC_1	1070:1074	PFTSS	SPOP	0.9837	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	1646:1650	PFTSS	SPOP	0.9077	More...
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	DEG_SPOP_SBC_1	755:759	PFTSS	SPOP	0.6167	More...
P41162	ETS translocation variant 3	DEG_SPOP_SBC_1	284:288	PFTSS	SPOP	0.8799	More...
Q04206	Transcription factor p65	DEG_SPOP_SBC_1	350:354	PFTSS	SPOP	0.9593	More...
Q8N680	Zinc finger and BTB domain-containing protein 2	DEG_SPOP_SBC_1	280:284	PFTSS	SPOP	0.6045	More...

Showing 1 to 6 of 6 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons