DegronMD

Uniprot ID: Q9UBC2

Source protein: Epidermal growth factor receptor substrate 15-like 1

Source gene: EPS15L1

Class: DEG_SPOP_SBC_1

Location: 755:759

E3 ligase: SPOP

DEGRON score: 0.6167

ASA_SCORE: 64.48

COIL: 0.7976

CONS_SCORE: 0.3726

DSS_SCORE: 0.6952

HELIX: 0.1138

FCONS_SCORE: 0.9414

RIG_SCORE: 0.6014

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P755S	TCGA-DA-A1I5	SKCM	TCGA	PFTSS	DEG_SPOP_SBC_1	0.6752
p.P755S	DO37447	SKCM	ICGC	PFTSS	DEG_SPOP_SBC_1	0.6752
p.Q746H	DO225213	BRCA	ICGC	PFTSS	DEG_SPOP_SBC_1	0.0833
p.Q746H	DO227529	BRCA	ICGC	PFTSS	DEG_SPOP_SBC_1	0.0833
p.S745R	DO229019	LICA	ICGC	PFTSS	DEG_SPOP_SBC_1	0.0556
p.D768E	DO229006	LICA	ICGC	PFTSS	DEG_SPOP_SBC_1	0.0833
p.D768E	DO229259	THCA	ICGC	PFTSS	DEG_SPOP_SBC_1	0.0833
p.A763T	SIDM00845	Burkitt's Lymphoma	GDSC	PFTSS	DEG_SPOP_SBC_1	0.2222
p.A763T	ACH-000786	Lymphoma	CCLE	PFTSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41162	ETS translocation variant 3	DEG_SPOP_SBC_1	284:288	PFTSS	SPOP	0.8799	More...
Q04206	Transcription factor p65	DEG_SPOP_SBC_1	350:354	PFTSS	SPOP	0.9593	More...
Q86UU0	B-cell CLL/lymphoma 9-like protein	DEG_SPOP_SBC_1	1070:1074	PFTSS	SPOP	0.9837	More...
Q8N680	Zinc finger and BTB domain-containing protein 2	DEG_SPOP_SBC_1	280:284	PFTSS	SPOP	0.6045	More...
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	DEG_SPOP_SBC_1	755:759	PFTSS	SPOP	0.6167	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	1646:1650	PFTSS	SPOP	0.9077	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons