DegronMD

Uniprot ID: Q8N680

Source protein: Zinc finger and BTB domain-containing protein 2

Source gene: ZBTB2

Class: DEG_SPOP_SBC_1

Location: 280:284

E3 ligase: SPOP

DEGRON score: 0.6045

ASA_SCORE: 55.38

COIL: 0.5864

CONS_SCORE: 0.4758

DSS_SCORE: 0.462

HELIX: 0.055

FCONS_SCORE: 0.9321

RIG_SCORE: 0.6987

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R290C	TCGA-06-5416	GBM	TCGA	PFTSS	DEG_SPOP_SBC_1	0.1667
p.R290C	TCGA-AP-A1DV	UCEC	TCGA	PFTSS	DEG_SPOP_SBC_1	0.1667
p.R290C	DO10880	GBM	ICGC	PFTSS	DEG_SPOP_SBC_1	0.1667
p.R290C	DO43186	UCEC	ICGC	PFTSS	DEG_SPOP_SBC_1	0.1667
p.T277I	TCGA-21-5783	LUSC	TCGA	PFTSS	DEG_SPOP_SBC_1	0.25
p.T277I	DO27437	LUSC	ICGC	PFTSS	DEG_SPOP_SBC_1	0.25
p.R290H	TCGA-59-2349	OV	TCGA	PFTSS	DEG_SPOP_SBC_1	0.1667
p.R290H	DO28621	OV	ICGC	PFTSS	DEG_SPOP_SBC_1	0.1667
p.Q286H	TCGA-EE-A2M7	SKCM	TCGA	PFTSS	DEG_SPOP_SBC_1	0.2778
p.Q286H	DO37847	SKCM	ICGC	PFTSS	DEG_SPOP_SBC_1	0.2778
p.H272R	SIDM01608	Endometrial Carcinoma	GDSC	PFTSS	DEG_SPOP_SBC_1	0.1111
p.H272R	ACH-000990	Endometrial/Uterine Cancer	CCLE	PFTSS	DEG_SPOP_SBC_1	0.1111
p.G278A	ACH-000868	Lung Cancer	CCLE	PFTSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41162	ETS translocation variant 3	DEG_SPOP_SBC_1	284:288	PFTSS	SPOP	0.8799	More...
Q04206	Transcription factor p65	DEG_SPOP_SBC_1	350:354	PFTSS	SPOP	0.9593	More...
Q86UU0	B-cell CLL/lymphoma 9-like protein	DEG_SPOP_SBC_1	1070:1074	PFTSS	SPOP	0.9837	More...
Q8N680	Zinc finger and BTB domain-containing protein 2	DEG_SPOP_SBC_1	280:284	PFTSS	SPOP	0.6045	More...
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	DEG_SPOP_SBC_1	755:759	PFTSS	SPOP	0.6167	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	1646:1650	PFTSS	SPOP	0.9077	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons