DegronMD - Q8N680(ZBTB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R290C	TCGA-06-5416	GBM	TCGA	PFTSS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.1667
p.R290C	TCGA-AP-A1DV	UCEC	TCGA	PFTSS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.1667
p.R290C	DO10880	GBM	ICGC	PFTSS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.1667
p.R290C	DO43186	UCEC	ICGC	PFTSS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.1667
p.T277I	TCGA-21-5783	LUSC	TCGA	PFTSS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.25
p.T277I	DO27437	LUSC	ICGC	PFTSS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.25
p.R290H	TCGA-59-2349	OV	TCGA	PFTSS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.1667
p.R290H	DO28621	OV	ICGC	PFTSS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.1667
p.Q170H	TCGA-AZ-6598	COAD	TCGA	TSRISQEQVPEA	DEG_COP1_1	163:174	Mutation altering degron motif	0.647
p.Q170H	DO10276	COAD	ICGC	TSRISQEQVPEA	DEG_COP1_1	163:174	Mutation altering degron motif	0.647
p.Q170H	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	TSRISQEQVPEA	DEG_COP1_1	163:174	Mutation altering degron motif	0.647
p.Q170H	ACH-000900	Lung Cancer	CCLE	TSRISQEQVPEA	DEG_COP1_1	163:174	Mutation altering degron motif	0.647
p.Q170H	NCI-H23	lung	COSMIC	TSRISQEQVPEA	DEG_COP1_1	163:174	Mutation altering degron motif	0.647
p.Q286H	TCGA-EE-A2M7	SKCM	TCGA	PFTSS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.2778
p.Q286H	DO37847	SKCM	ICGC	PFTSS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.2778
p.E169K	TCGA-EK-A2RD	CESC	TCGA	TSRISQEQVPEA	DEG_COP1_1	163:174	Mutation altering degron motif	0.591
p.E169K	DO49946	CESC	ICGC	TSRISQEQVPEA	DEG_COP1_1	163:174	Mutation altering degron motif	0.591
p.R160L	TCGA-G3-A6UC	LIHC	TCGA	TSRISQEQVPEA	DEG_COP1_1	163:174	Mutation rewiring degron network	0.25
p.R160L	DO48559	LIHC	ICGC	TSRISQEQVPEA	DEG_COP1_1	163:174	Mutation rewiring degron network	0.25
p.G156R	TCGA-HU-A4GX	STAD	TCGA	TSRISQEQVPEA	DEG_COP1_1	163:174	Mutation rewiring degron network	0.1389
p.G156R	DO47757	STAD	ICGC	TSRISQEQVPEA	DEG_COP1_1	163:174	Mutation rewiring degron network	0.1389
p.Q176H	TCGA-KR-A7K8	LIHC	TCGA	TSRISQEQVPEA	DEG_COP1_1	163:174	Mutation rewiring degron network	0.2778
p.Q176H	DO52305	LIHC	ICGC	TSRISQEQVPEA	DEG_COP1_1	163:174	Mutation rewiring degron network	0.2778
p.T163N	DO229015	LICA	ICGC	TSRISQEQVPEA	DEG_COP1_1	163:174	Mutation altering degron motif	0.7055
p.S167R	DO229029	LICA	ICGC	TSRISQEQVPEA	DEG_COP1_1	163:174	Mutation altering degron motif	0.8538
p.E153G	SIDM00608	Plasma Cell Myeloma	GDSC	TSRISQEQVPEA	DEG_COP1_1	163:174	Mutation rewiring degron network	0.0556
p.E153G	ACH-000714	Myeloma	CCLE	TSRISQEQVPEA	DEG_COP1_1	163:174	Mutation rewiring degron network	0.0556
p.E153G	KMS-11	haematopoietic and lymphoid tissue	COSMIC	TSRISQEQVPEA	DEG_COP1_1	163:174	Mutation rewiring degron network	0.0556
p.H272R	SIDM01608	Endometrial Carcinoma	GDSC	PFTSS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.1111
p.H272R	ACH-000990	Endometrial/Uterine Cancer	CCLE	PFTSS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.1111
p.G278A	ACH-000868	Lung Cancer	CCLE	PFTSS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.2778
p.E173K	ACH-001415	Bladder Cancer	CCLE	TSRISQEQVPEA	DEG_COP1_1	163:174	Mutation altering degron motif	0.7022

Kaplan plot for ZBTB2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZBTB2

UniProt ID: Q8N680

Entrez ID: 57621

Protein name: Zinc finger and BTB domain-containing protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZBTB2 in