DegronMD

Uniprot ID: Q8N680

Source protein: Zinc finger and BTB domain-containing protein 2

Source gene: ZBTB2

Class: DEG_COP1_1

Location: 163:174

E3 ligase: COP1

DEGRON score: 0.7638

ASA_SCORE: 96.6667

COIL: 0.8058

CONS_SCORE: 0.4938

DSS_SCORE: 0.7191

HELIX: 0.1244

FCONS_SCORE: 0.9853

RIG_SCORE: 0.6601

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q170H	TCGA-AZ-6598	COAD	TCGA	TSRISQEQVPEA	DEG_COP1_1	0.647
p.Q170H	DO10276	COAD	ICGC	TSRISQEQVPEA	DEG_COP1_1	0.647
p.Q170H	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	TSRISQEQVPEA	DEG_COP1_1	0.647
p.Q170H	ACH-000900	Lung Cancer	CCLE	TSRISQEQVPEA	DEG_COP1_1	0.647
p.Q170H	NCI-H23	lung	COSMIC	TSRISQEQVPEA	DEG_COP1_1	0.647
p.E169K	TCGA-EK-A2RD	CESC	TCGA	TSRISQEQVPEA	DEG_COP1_1	0.591
p.E169K	DO49946	CESC	ICGC	TSRISQEQVPEA	DEG_COP1_1	0.591
p.R160L	TCGA-G3-A6UC	LIHC	TCGA	TSRISQEQVPEA	DEG_COP1_1	0.25
p.R160L	DO48559	LIHC	ICGC	TSRISQEQVPEA	DEG_COP1_1	0.25
p.G156R	TCGA-HU-A4GX	STAD	TCGA	TSRISQEQVPEA	DEG_COP1_1	0.1389
p.G156R	DO47757	STAD	ICGC	TSRISQEQVPEA	DEG_COP1_1	0.1389
p.Q176H	TCGA-KR-A7K8	LIHC	TCGA	TSRISQEQVPEA	DEG_COP1_1	0.2778
p.Q176H	DO52305	LIHC	ICGC	TSRISQEQVPEA	DEG_COP1_1	0.2778
p.T163N	DO229015	LICA	ICGC	TSRISQEQVPEA	DEG_COP1_1	0.7055
p.S167R	DO229029	LICA	ICGC	TSRISQEQVPEA	DEG_COP1_1	0.8538
p.E153G	SIDM00608	Plasma Cell Myeloma	GDSC	TSRISQEQVPEA	DEG_COP1_1	0.0556
p.E153G	ACH-000714	Myeloma	CCLE	TSRISQEQVPEA	DEG_COP1_1	0.0556
p.E153G	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	TSRISQEQVPEA	DEG_COP1_1	0.0556
p.E173K	ACH-001415	Bladder Cancer	CCLE	TSRISQEQVPEA	DEG_COP1_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N680	Zinc finger and BTB domain-containing protein 2	DEG_COP1_1	163:174	TSRISQEQVPEA	COP1	0.7638	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons