DegronMD - P41162(ETV3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P232H	TCGA-AP-A059	UCEC	TCGA	RPGMYPD	LIG_APCC_ABBAyCdc20_2	236:242	Mutation rewiring degron network	0.2222
p.P232H	DO41361	UCEC	ICGC	RPGMYPD	LIG_APCC_ABBAyCdc20_2	236:242	Mutation rewiring degron network	0.2222
p.I437V	TCGA-AP-A1DK	UCEC	TCGA	PISTPSGE	DEG_SCF_FBW7_2	436:443	Mutation altering degron motif	0.5965
p.I437V	DO42033	UCEC	ICGC	PISTPSGE	DEG_SCF_FBW7_2	436:443	Mutation altering degron motif	0.5965
p.V249A	TCGA-AX-A0J0	UCEC	TCGA	RPGMYPD	LIG_APCC_ABBAyCdc20_2	236:242	Mutation rewiring degron network	0.1389
p.V249A	DO41133	UCEC	ICGC	RPGMYPD	LIG_APCC_ABBAyCdc20_2	236:242	Mutation rewiring degron network	0.1389
p.L231R	TCGA-AX-A0J0	UCEC	TCGA	RPGMYPD	LIG_APCC_ABBAyCdc20_2	236:242	Mutation rewiring degron network	0.1944
p.L231R	DO41133	UCEC	ICGC	RPGMYPD	LIG_APCC_ABBAyCdc20_2	236:242	Mutation rewiring degron network	0.1944
p.S275P	TCGA-CC-A3MC	LIHC	TCGA	PFTSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.0833
p.S275P	DO22893	LIHC	ICGC	PFTSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.0833
p.P440S	TCGA-DF-A2KN	UCEC	TCGA	PISTPSGE	DEG_SCF_FBW7_2	436:443	Mutation altering degron motif	0.6752
p.P440S	DO223282	UCEC	ICGC	PISTPSGE	DEG_SCF_FBW7_2	436:443	Mutation altering degron motif	0.6752
p.P284H	TCGA-DF-A2KU	UCEC	TCGA	PFTSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7694
p.P284H	DO223286	UCEC	ICGC	PFTSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7694
p.L233R	TCGA-EY-A215	UCEC	TCGA	RPGMYPD	LIG_APCC_ABBAyCdc20_2	236:242	Mutation rewiring degron network	0.25
p.L233R	DO42665	UCEC	ICGC	RPGMYPD	LIG_APCC_ABBAyCdc20_2	236:242	Mutation rewiring degron network	0.25
p.P251A	TCGA-KP-A3W4	UCEC	TCGA	RPGMYPD	LIG_APCC_ABBAyCdc20_2	236:242	Mutation rewiring degron network	0.0833
p.P251A	DO219781	UCEC	ICGC	RPGMYPD	LIG_APCC_ABBAyCdc20_2	236:242	Mutation rewiring degron network	0.0833
p.S287T	TCGA-SJ-A6ZI	UCEC	TCGA	PFTSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.6005
p.S287T	DO219784	UCEC	ICGC	PFTSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.6005
p.A248T	DO222794	COCA	ICGC	RPGMYPD	LIG_APCC_ABBAyCdc20_2	236:242	Mutation rewiring degron network	0.1667
p.A248T	SIDM00537	Colorectal Carcinoma	GDSC	RPGMYPD	LIG_APCC_ABBAyCdc20_2	236:242	Mutation rewiring degron network	0.1667
p.A248T	GP5d	large intestine	COSMIC	RPGMYPD	LIG_APCC_ABBAyCdc20_2	236:242	Mutation rewiring degron network	0.1667
p.P232R	DO10839	ESAD	ICGC	RPGMYPD	LIG_APCC_ABBAyCdc20_2	236:242	Mutation rewiring degron network	0.2222
p.P430T	DO228948	LICA	ICGC	PISTPSGE	DEG_SCF_FBW7_2	436:443	Mutation rewiring degron network	0.1667
p.L231I	DO229019	LICA	ICGC	RPGMYPD	LIG_APCC_ABBAyCdc20_2	236:242	Mutation rewiring degron network	0.1944
p.S277R	DO229022	LICA	ICGC	PFTSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1389
p.S288R	DO229026	LICA	ICGC	PFTSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7427
p.D242E	DO229008	LICA	ICGC	RPGMYPD	LIG_APCC_ABBAyCdc20_2	236:242	Mutation altering degron motif	0.5647
p.P280Q	DO229008	LICA	ICGC	PFTSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.2222
p.D450Y	SIDM00807	Bladder Carcinoma	GDSC	PISTPSGE	DEG_SCF_FBW7_2	436:443	Mutation rewiring degron network	0.1389
p.D450Y	ACH-000905	Bladder Cancer	CCLE	PISTPSGE	DEG_SCF_FBW7_2	436:443	Mutation rewiring degron network	0.1389
p.D450Y	5637	urinary tract	COSMIC	PISTPSGE	DEG_SCF_FBW7_2	436:443	Mutation rewiring degron network	0.1389
p.A235T	ACH-000165	Non-Cancerous	CCLE	RPGMYPD	LIG_APCC_ABBAyCdc20_2	236:242	Mutation rewiring degron network	0.3056
p.Y276C	ACH-000682	Head and Neck Cancer	CCLE	PFTSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1111
p.S287N	ACH-001591	Lung Cancer	CCLE	PFTSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7069
p.S287N	NCI-H1417	lung	COSMIC	PFTSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7069
p.A235S	ACH-001737	Leukemia	CCLE	RPGMYPD	LIG_APCC_ABBAyCdc20_2	236:242	Mutation rewiring degron network	0.3056

Kaplan plot for ETV3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ETV3

UniProt ID: P41162

Entrez ID: 2117

Protein name: ETS translocation variant 3 (ETS domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ETV3 in