DegronMD

Uniprot ID: P41162

Source protein: ETS translocation variant 3

Source gene: ETV3

Class: LIG_APCC_ABBAyCdc20_2

Location: 236:242

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9987

ASA_SCORE: 74.9429

COIL: 0.9464

CONS_SCORE: 0.4472

DSS_SCORE: 0.3646

HELIX: 0.017

FCONS_SCORE: 0.8093

RIG_SCORE: 0.6593

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P232H	TCGA-AP-A059	UCEC	TCGA	RPGMYPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.P232H	DO41361	UCEC	ICGC	RPGMYPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.V249A	TCGA-AX-A0J0	UCEC	TCGA	RPGMYPD	LIG_APCC_ABBAyCdc20_2	0.1389
p.V249A	DO41133	UCEC	ICGC	RPGMYPD	LIG_APCC_ABBAyCdc20_2	0.1389
p.L231R	TCGA-AX-A0J0	UCEC	TCGA	RPGMYPD	LIG_APCC_ABBAyCdc20_2	0.1944
p.L231R	DO41133	UCEC	ICGC	RPGMYPD	LIG_APCC_ABBAyCdc20_2	0.1944
p.L233R	TCGA-EY-A215	UCEC	TCGA	RPGMYPD	LIG_APCC_ABBAyCdc20_2	0.25
p.L233R	DO42665	UCEC	ICGC	RPGMYPD	LIG_APCC_ABBAyCdc20_2	0.25
p.P251A	TCGA-KP-A3W4	UCEC	TCGA	RPGMYPD	LIG_APCC_ABBAyCdc20_2	0.0833
p.P251A	DO219781	UCEC	ICGC	RPGMYPD	LIG_APCC_ABBAyCdc20_2	0.0833
p.A248T	DO222794	COCA	ICGC	RPGMYPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.A248T	SIDM00537	Colorectal Carcinoma	GDSC	RPGMYPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.A248T	GP5d	large_intestine	COSMIC	RPGMYPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.P232R	DO10839	ESAD	ICGC	RPGMYPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.L231I	DO229019	LICA	ICGC	RPGMYPD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D242E	DO229008	LICA	ICGC	RPGMYPD	LIG_APCC_ABBAyCdc20_2	0.5647
p.A235T	ACH-000165	Non-Cancerous	CCLE	RPGMYPD	LIG_APCC_ABBAyCdc20_2	0.3056
p.A235S	ACH-001737	Leukemia	CCLE	RPGMYPD	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41162	ETS translocation variant 3	LIG_APCC_ABBAyCdc20_2	236:242	RPGMYPD	APC,CDC20,FZR1	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons