DegronMD

Uniprot ID: P41162

Source protein: ETS translocation variant 3

Source gene: ETV3

Class: DEG_SPOP_SBC_1

Location: 284:288

E3 ligase: SPOP

DEGRON score: 0.8799

ASA_SCORE: 66.34

COIL: 0.8952

CONS_SCORE: 0.4621

DSS_SCORE: 0.2281

HELIX: 0.0574

FCONS_SCORE: 0.8621

RIG_SCORE: 0.704

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S275P	TCGA-CC-A3MC	LIHC	TCGA	PFTSS	DEG_SPOP_SBC_1	0.0833
p.S275P	DO22893	LIHC	ICGC	PFTSS	DEG_SPOP_SBC_1	0.0833
p.P284H	TCGA-DF-A2KU	UCEC	TCGA	PFTSS	DEG_SPOP_SBC_1	0.7694
p.P284H	DO223286	UCEC	ICGC	PFTSS	DEG_SPOP_SBC_1	0.7694
p.S287T	TCGA-SJ-A6ZI	UCEC	TCGA	PFTSS	DEG_SPOP_SBC_1	0.6005
p.S287T	DO219784	UCEC	ICGC	PFTSS	DEG_SPOP_SBC_1	0.6005
p.S277R	DO229022	LICA	ICGC	PFTSS	DEG_SPOP_SBC_1	0.1389
p.S288R	DO229026	LICA	ICGC	PFTSS	DEG_SPOP_SBC_1	0.7427
p.P280Q	DO229008	LICA	ICGC	PFTSS	DEG_SPOP_SBC_1	0.2222
p.Y276C	ACH-000682	Head and Neck Cancer	CCLE	PFTSS	DEG_SPOP_SBC_1	0.1111
p.S287N	ACH-001591	Lung Cancer	CCLE	PFTSS	DEG_SPOP_SBC_1	0.7069
p.S287N	NCI-H1417	lung	COSMIC	PFTSS	DEG_SPOP_SBC_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41162	ETS translocation variant 3	DEG_SPOP_SBC_1	284:288	PFTSS	SPOP	0.8799	More...
Q04206	Transcription factor p65	DEG_SPOP_SBC_1	350:354	PFTSS	SPOP	0.9593	More...
Q86UU0	B-cell CLL/lymphoma 9-like protein	DEG_SPOP_SBC_1	1070:1074	PFTSS	SPOP	0.9837	More...
Q8N680	Zinc finger and BTB domain-containing protein 2	DEG_SPOP_SBC_1	280:284	PFTSS	SPOP	0.6045	More...
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	DEG_SPOP_SBC_1	755:759	PFTSS	SPOP	0.6167	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	1646:1650	PFTSS	SPOP	0.9077	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons