DegronMD

Uniprot ID: Q04206

Source protein: Transcription factor p65

Source gene: RELA

Class: DEG_SPOP_SBC_1

Location: 350:354

E3 ligase: SPOP

DEGRON score: 0.9593

ASA_SCORE: 69.72

COIL: 0.7922

CONS_SCORE: 0.3921

DSS_SCORE: 0.4547

HELIX: 0.153

FCONS_SCORE: 1.0421

RIG_SCORE: 0.7063

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D347Y	DO51612	CESC	ICGC	PFTSS	DEG_SPOP_SBC_1	0.25
p.S364R	DO230326	COCA	ICGC	PFTSS	DEG_SPOP_SBC_1	0.0556
p.S364R	DO233295	NACA	ICGC	PFTSS	DEG_SPOP_SBC_1	0.0556
p.S358I	DO50323	ESAD	ICGC	PFTSS	DEG_SPOP_SBC_1	0.2222
p.P350H	DO228948	LICA	ICGC	PFTSS	DEG_SPOP_SBC_1	0.7694
p.L355M	DO229038	LICA	ICGC	PFTSS	DEG_SPOP_SBC_1	0.3056
p.S351F	DO220906	MELA	ICGC	PFTSS	DEG_SPOP_SBC_1	0.7982
p.L362P	DO50127	STAD	ICGC	PFTSS	DEG_SPOP_SBC_1	0.1111
p.P350L	SIDM00545	Melanoma	GDSC	PFTSS	DEG_SPOP_SBC_1	0.7582
p.P350L	ACH-000987	Skin Cancer	CCLE	PFTSS	DEG_SPOP_SBC_1	0.7582
p.P350L	Mewo	skin	COSMIC	PFTSS	DEG_SPOP_SBC_1	0.7582
p.S340F	SIDM01617	Endometrial Carcinoma	GDSC	PFTSS	DEG_SPOP_SBC_1	0.0556
p.S340F	ACH-000994	Endometrial/Uterine Cancer	CCLE	PFTSS	DEG_SPOP_SBC_1	0.0556
p.Q361H	KMH-2	thyroid	COSMIC	PFTSS	DEG_SPOP_SBC_1	0.1389
p.Q361H	KURAMOCHI	ovary	COSMIC	PFTSS	DEG_SPOP_SBC_1	0.1389
p.S359F	KURAMOCHI	ovary	COSMIC	PFTSS	DEG_SPOP_SBC_1	0.1944
p.S359F	KMH-2	thyroid	COSMIC	PFTSS	DEG_SPOP_SBC_1	0.1944
p.P347L	Mewo	skin	COSMIC	PFTSS	DEG_SPOP_SBC_1	0.25
p.T362A	CCK-81	large_intestine	COSMIC	PFTSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41162	ETS translocation variant 3	DEG_SPOP_SBC_1	284:288	PFTSS	SPOP	0.8799	More...
Q04206	Transcription factor p65	DEG_SPOP_SBC_1	350:354	PFTSS	SPOP	0.9593	More...
Q86UU0	B-cell CLL/lymphoma 9-like protein	DEG_SPOP_SBC_1	1070:1074	PFTSS	SPOP	0.9837	More...
Q8N680	Zinc finger and BTB domain-containing protein 2	DEG_SPOP_SBC_1	280:284	PFTSS	SPOP	0.6045	More...
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	DEG_SPOP_SBC_1	755:759	PFTSS	SPOP	0.6167	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	1646:1650	PFTSS	SPOP	0.9077	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons