DegronMD

Uniprot ID: Q9UIF8

Source protein: Bromodomain adjacent to zinc finger domain protein 2B

Source gene: BAZ2B

Class: DEG_SPOP_SBC_1

Location: 1646:1650

E3 ligase: SPOP

DEGRON score: 0.9077

ASA_SCORE: 83.68

COIL: 0.9188

CONS_SCORE: 0.3421

DSS_SCORE: 0.2687

HELIX: 0.0228

FCONS_SCORE: 0.985

RIG_SCORE: 0.8013

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1643C	TCGA-FD-A6TC	BLCA	TCGA	PFTSS	DEG_SPOP_SBC_1	0.25
p.G1639R	TCGA-OR-A5KB	ACC	TCGA	PFTSS	DEG_SPOP_SBC_1	0.1389
p.A1659V	DO230342	COCA	ICGC	PFTSS	DEG_SPOP_SBC_1	0.0833
p.A1652D	DO222755	COCA	ICGC	PFTSS	DEG_SPOP_SBC_1	0.2778
p.Q1648K	DO229029	LICA	ICGC	PFTSS	DEG_SPOP_SBC_1	0.6944
p.K1651N	DO42033	UCEC	ICGC	PFTSS	DEG_SPOP_SBC_1	0.3056
p.V1637A	DO42201	UCEC	ICGC	PFTSS	DEG_SPOP_SBC_1	0.0833
p.E1643G	DO41235	UCEC	ICGC	PFTSS	DEG_SPOP_SBC_1	0.25
p.L1654V	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	PFTSS	DEG_SPOP_SBC_1	0.2222
p.L1654V	ACH-000343	Lung Cancer	CCLE	PFTSS	DEG_SPOP_SBC_1	0.2222
p.L1654V	NCI-H522	lung	COSMIC	PFTSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41162	ETS translocation variant 3	DEG_SPOP_SBC_1	284:288	PFTSS	SPOP	0.8799	More...
Q04206	Transcription factor p65	DEG_SPOP_SBC_1	350:354	PFTSS	SPOP	0.9593	More...
Q86UU0	B-cell CLL/lymphoma 9-like protein	DEG_SPOP_SBC_1	1070:1074	PFTSS	SPOP	0.9837	More...
Q8N680	Zinc finger and BTB domain-containing protein 2	DEG_SPOP_SBC_1	280:284	PFTSS	SPOP	0.6045	More...
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	DEG_SPOP_SBC_1	755:759	PFTSS	SPOP	0.6167	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	1646:1650	PFTSS	SPOP	0.9077	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons