DegronMD - Q9UIF8(BAZ2B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S30A	TCGA-06-5416	GBM	TCGA	PTSSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.0833
p.S30A	DO10880	GBM	ICGC	PTSSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.0833
p.S465C	TCGA-17-Z026	LUAD	TCGA	ATSSS	DEG_SPOP_SBC_1	463:467	Mutation altering degron motif	0.8652
p.I455L	TCGA-2H-A9GO	ESCA	TCGA	ATSSS	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.1111
p.T474K	TCGA-80-5607	LUAD	TCGA	ATSSS	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.1389
p.A525V	TCGA-90-A4ED	LUSC	TCGA	AASST	DEG_SPOP_SBC_1	525:529	Mutation altering degron motif	0.5825
p.A525V	SIDM01113	Other Sarcomas	GDSC	AASST	DEG_SPOP_SBC_1	525:529	Mutation altering degron motif	0.5825
p.A525V	ACH-000939	Sarcoma	CCLE	AASST	DEG_SPOP_SBC_1	525:529	Mutation altering degron motif	0.5825
p.A525V	SK-UT-1	soft tissue	COSMIC	AASST	DEG_SPOP_SBC_1	525:529	Mutation altering degron motif	0.5825
p.S245N	TCGA-A5-A1OF	UCEC	TCGA	DSGTSS	DEG_SCF_TRCP1_1	248:253	Mutation rewiring degron network	0.25
p.S2019C	TCGA-A8-A07F	BRCA	TCGA	ASTSS	DEG_SPOP_SBC_1	2020:2024	Mutation blocking phosphorylation signal	0.75
p.S2019C	SIDM00272	Breast Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	2020:2024	Mutation blocking phosphorylation signal	0.75
p.S2019C	ACH-000910	Breast Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	2020:2024	Mutation blocking phosphorylation signal	0.75
p.S2019C	MDA-MB-453	breast	COSMIC	ASTSS	DEG_SPOP_SBC_1	2020:2024	Mutation blocking phosphorylation signal	0.75
p.R6W	TCGA-AA-A010	COAD	TCGA	AASST	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.1944
p.R6W	SIDM00537	Colorectal Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.1944
p.R6W	SIDM00079	Ovarian Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.1944
p.R6W	ACH-000811	Ovarian Cancer	CCLE	AASST	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.1944
p.R6W	ACH-001345	Colon/Colorectal Cancer	CCLE	AASST	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.1944
p.R6W	SK-OV-3	ovary	COSMIC	AASST	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.1944
p.R6W	GP5d	large intestine	COSMIC	AASST	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.1944
p.S261G	TCGA-AX-A060	UCEC	TCGA	DSGTSS	DEG_SCF_TRCP1_1	248:253	Mutation rewiring degron network	0.1111
p.S10L	TCGA-B6-A1KF	BRCA	TCGA	AASST	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.3056
p.S10L	TCGA-B6-A1KF	BRCA	TCGA	PTSSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1389
p.S10L	DO1604	BRCA	ICGC	AASST	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.3056
p.S10L	DO1604	BRCA	ICGC	PTSSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1389
p.G259S	TCGA-CF-A1HR	BLCA	TCGA	DSGTSS	DEG_SCF_TRCP1_1	248:253	Mutation rewiring degron network	0.1667
p.S261N	TCGA-CG-5728	STAD	TCGA	DSGTSS	DEG_SCF_TRCP1_1	248:253	Mutation rewiring degron network	0.1111
p.S532F	TCGA-D3-A51J	SKCM	TCGA	AASST	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.25
p.P468L	TCGA-EE-A20C	SKCM	TCGA	ATSSS	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.3056
p.S21L	TCGA-EO-A22U	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	17:21	Mutation altering degron motif	0.7667
p.S21L	DO43755	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	17:21	Mutation altering degron motif	0.7667
p.S1643C	TCGA-FD-A6TC	BLCA	TCGA	PFTSS	DEG_SPOP_SBC_1	1646:1650	Mutation rewiring degron network	0.25
p.G1639R	TCGA-OR-A5KB	ACC	TCGA	PFTSS	DEG_SPOP_SBC_1	1646:1650	Mutation rewiring degron network	0.1389
p.G257S	DO469	BLCA	ICGC	DSGTSS	DEG_SCF_TRCP1_1	248:253	Mutation rewiring degron network	0.2222
p.G248D	DO225382	BRCA	ICGC	DSGTSS	DEG_SCF_TRCP1_1	248:253	Mutation altering degron motif	0.7198
p.P528L	DO228483	BRCA	ICGC	AASST	DEG_SPOP_SBC_1	525:529	Mutation altering degron motif	0.7582
p.P528L	DO227999	COCA	ICGC	AASST	DEG_SPOP_SBC_1	525:529	Mutation altering degron motif	0.7582
p.P528L	DO229005	COCA	ICGC	AASST	DEG_SPOP_SBC_1	525:529	Mutation altering degron motif	0.7582
p.P528L	DO229505	LAML	ICGC	AASST	DEG_SPOP_SBC_1	525:529	Mutation altering degron motif	0.7582
p.P528L	DO52365	LUSC	ICGC	AASST	DEG_SPOP_SBC_1	525:529	Mutation altering degron motif	0.7582
p.N476S	DO8360	COAD	ICGC	ATSSS	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.0833
p.A1659V	DO230342	COCA	ICGC	PFTSS	DEG_SPOP_SBC_1	1646:1650	Mutation rewiring degron network	0.0833
p.A1652D	DO222755	COCA	ICGC	PFTSS	DEG_SPOP_SBC_1	1646:1650	Mutation rewiring degron network	0.2778
p.S2024N	DO229003	COCA	ICGC	ASTSS	DEG_SPOP_SBC_1	2020:2024	Mutation altering degron motif	0.7069
p.S2024N	DO234285	ESAD	ICGC	ASTSS	DEG_SPOP_SBC_1	2020:2024	Mutation altering degron motif	0.7069
p.A524V	DO234199	ESAD	ICGC	AASST	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.3056
p.A524T	DO234390	ESAD	ICGC	AASST	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.3056
p.E474Q	DO222744	ESCA	ICGC	ATSSS	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.1389
p.K2034R	DO228313	LICA	ICGC	ASTSS	DEG_SPOP_SBC_1	2020:2024	Mutation substituting flanking lysine	0.1667
p.S20F	DO228946	LICA	ICGC	PTSSS	DEG_SPOP_SBC_1	17:21	Mutation altering degron motif	0.9093
p.A467E	DO229018	LICA	ICGC	ATSSS	DEG_SPOP_SBC_1	463:467	Mutation altering degron motif	0.7701
p.P466T	DO229018	LICA	ICGC	ATSSS	DEG_SPOP_SBC_1	463:467	Mutation altering degron motif	0.7031
p.P466T	DO229019	LICA	ICGC	ATSSS	DEG_SPOP_SBC_1	463:467	Mutation altering degron motif	0.7031
p.D252E	DO229029	LICA	ICGC	DSGTSS	DEG_SCF_TRCP1_1	248:253	Mutation altering degron motif	0.6758
p.Q1648K	DO229029	LICA	ICGC	PFTSS	DEG_SPOP_SBC_1	1646:1650	Mutation altering degron motif	0.6944
p.T15N	DO229028	LICA	ICGC	AASST	DEG_SPOP_SBC_1	11:15	Mutation altering degron motif	0.7055
p.H477N	DO229027	LICA	ICGC	ATSSS	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.0556
p.H468N	DO229035	LICA	ICGC	ATSSS	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.3056
p.E519D	DO44790	LICA	ICGC	AASST	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.1667
p.S464T	DO45299	LIRI	ICGC	ATSSS	DEG_SPOP_SBC_1	463:467	Mutation altering degron motif	0.7116
p.S2023G	DO48709	LIRI	ICGC	ASTSS	DEG_SPOP_SBC_1	2020:2024	Mutation altering degron motif	0.6993
p.T472K	DO25957	LUAD	ICGC	ATSSS	DEG_SPOP_SBC_1	463:467	Mutation substituting flanking lysine	0.3056
p.E256D	DO231091	LUSC	ICGC	DSGTSS	DEG_SCF_TRCP1_1	248:253	Mutation rewiring degron network	0.25
p.A523V	DO45482	LUSC	ICGC	AASST	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.2778
p.A523V	SK-UT-1	soft tissue	COSMIC	AASST	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.2778
p.P466L	DO222775	MELA	ICGC	ATSSS	DEG_SPOP_SBC_1	463:467	Mutation altering degron motif	0.7582
p.P466L	DO47665	SKCM	ICGC	ATSSS	DEG_SPOP_SBC_1	463:467	Mutation altering degron motif	0.7582
p.S530F	DO47359	SKCM	ICGC	AASST	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.3056
p.S259N	DO38619	STAD	ICGC	DSGTSS	DEG_SCF_TRCP1_1	248:253	Mutation rewiring degron network	0.1667
p.D262N	DO229242	THCA	ICGC	DSGTSS	DEG_SCF_TRCP1_1	248:253	Mutation rewiring degron network	0.0833
p.K1651N	DO42033	UCEC	ICGC	PFTSS	DEG_SPOP_SBC_1	1646:1650	Mutation rewiring degron network	0.3056
p.V1637A	DO42201	UCEC	ICGC	PFTSS	DEG_SPOP_SBC_1	1646:1650	Mutation rewiring degron network	0.0833
p.S259G	DO42576	UCEC	ICGC	DSGTSS	DEG_SCF_TRCP1_1	248:253	Mutation rewiring degron network	0.1667
p.S243N	DO42568	UCEC	ICGC	DSGTSS	DEG_SCF_TRCP1_1	248:253	Mutation rewiring degron network	0.1944
p.E1643G	DO41235	UCEC	ICGC	PFTSS	DEG_SPOP_SBC_1	1646:1650	Mutation rewiring degron network	0.25
p.P461T	SIDM00845	Burkitt's Lymphoma	GDSC	ATSSS	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.2778
p.P461T	SIDM00035	Thyroid Gland Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.2778
p.P461T	SIDM00461	Acute Myeloid Leukemia	GDSC	ATSSS	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.2778
p.P461T	SIDM01519	Head and Neck Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.2778
p.K518Q	SIDM00585	Hepatocellular Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	525:529	Mutation substituting flanking lysine	0.25
p.K518Q	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	525:529	Mutation substituting flanking lysine	0.25
p.K518Q	ACH-000480	Liver Cancer	CCLE	AASST	DEG_SPOP_SBC_1	525:529	Mutation substituting flanking lysine	0.25
p.K518Q	ACH-000858	Lung Cancer	CCLE	AASST	DEG_SPOP_SBC_1	525:529	Mutation substituting flanking lysine	0.25
p.L1654V	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	PFTSS	DEG_SPOP_SBC_1	1646:1650	Mutation rewiring degron network	0.2222
p.L1654V	ACH-000343	Lung Cancer	CCLE	PFTSS	DEG_SPOP_SBC_1	1646:1650	Mutation rewiring degron network	0.2222
p.L1654V	NCI-H522	lung	COSMIC	PFTSS	DEG_SPOP_SBC_1	1646:1650	Mutation rewiring degron network	0.2222
p.P23H	SIDM00217	Colorectal Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.1111
p.P23H	SIDM00217	Colorectal Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2778
p.P23H	ACH-000999	Colon/Colorectal Cancer	CCLE	AASST	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.1111
p.P23H	ACH-000999	Colon/Colorectal Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2778
p.P23H	SNU-1040	large intestine	COSMIC	AASST	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.1111
p.P23H	SNU-1040	large intestine	COSMIC	PTSSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2778
p.T251R	SIDM01320	Pancreatic Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	248:253	Mutation altering degron motif	0.6765
p.T251R	ACH-000468	Pancreatic Cancer	CCLE	DSGTSS	DEG_SCF_TRCP1_1	248:253	Mutation altering degron motif	0.6765
p.V28I	ACH-000088	Non-Cancerous	CCLE	PTSSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1389
p.A26G	ACH-001283	Bone Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1944
p.S261C	ACH-001395	Breast Cancer	CCLE	DSGTSS	DEG_SCF_TRCP1_1	248:253	Mutation rewiring degron network	0.1111
p.A241T	KP-1N	pancreas	COSMIC	DSGTSS	DEG_SCF_TRCP1_1	248:253	Mutation rewiring degron network	0.1389
p.R14Q	SNU-C1	large intestine	COSMIC	AASST	DEG_SPOP_SBC_1	11:15	Mutation altering degron motif	0.7329
p.E456Q	NCI-H1734	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.1389
p.L535S	KYSE-70	oesophagus	COSMIC	AASST	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.1667
p.C16Y	GP5d	large intestine	COSMIC	AASST	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.3056
p.C16Y	GP5d	large intestine	COSMIC	PTSSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.3056
p.R2024G	NCI-H510A	lung	COSMIC	ASTSS	DEG_SPOP_SBC_1	2020:2024	Mutation altering degron motif	0.7568

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BAZ2B

UniProt ID: Q9UIF8

Entrez ID: 29994

Protein name: Bromodomain adjacent to zinc finger domain protein 2B (hWALp4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BAZ2B in