DegronMD

Uniprot ID: Q9UIF8

Source protein: Bromodomain adjacent to zinc finger domain protein 2B

Source gene: BAZ2B

Class: DEG_SCF_TRCP1_1

Location: 248:253

E3 ligase: BTRC

DEGRON score: 0.9889

ASA_SCORE: 88.3333

COIL: 0.9597

CONS_SCORE: 0.4553

DSS_SCORE: 0.7482

HELIX: 0.029

FCONS_SCORE: 1.1137

RIG_SCORE: 0.4518

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S245N	TCGA-A5-A1OF	UCEC	TCGA	DSGTSS	DEG_SCF_TRCP1_1	0.25
p.S261G	TCGA-AX-A060	UCEC	TCGA	DSGTSS	DEG_SCF_TRCP1_1	0.1111
p.G259S	TCGA-CF-A1HR	BLCA	TCGA	DSGTSS	DEG_SCF_TRCP1_1	0.1667
p.S261N	TCGA-CG-5728	STAD	TCGA	DSGTSS	DEG_SCF_TRCP1_1	0.1111
p.G257S	DO469	BLCA	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.2222
p.G248D	DO225382	BRCA	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.7198
p.D252E	DO229029	LICA	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.6758
p.E256D	DO231091	LUSC	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.25
p.S259N	DO38619	STAD	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.1667
p.D262N	DO229242	THCA	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.0833
p.S259G	DO42576	UCEC	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.1667
p.S243N	DO42568	UCEC	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.1944
p.T251R	SIDM01320	Pancreatic Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.6765
p.T251R	ACH-000468	Pancreatic Cancer	CCLE	DSGTSS	DEG_SCF_TRCP1_1	0.6765
p.S261C	ACH-001395	Breast Cancer	CCLE	DSGTSS	DEG_SCF_TRCP1_1	0.1111
p.A241T	KP-1N	pancreas	COSMIC	DSGTSS	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A5PKW4	PH and SEC7 domain-containing protein 1	DEG_SCF_TRCP1_1	467:472	DSGTSS	BTRC	0.8696	More...
O94901	SUN domain-containing protein 1	DEG_SCF_TRCP1_1	74:79	DSGTSS	BTRC	0.9911	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SCF_TRCP1_1	248:253	DSGTSS	BTRC	0.9889	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons