DegronMD

Uniprot ID: A5PKW4

Source protein: PH and SEC7 domain-containing protein 1

Source gene: PSD

Class: DEG_SCF_TRCP1_1

Location: 467:472

E3 ligase: BTRC

DEGRON score: 0.8696

ASA_SCORE: 71.5667

COIL: 0.8688

CONS_SCORE: 0.2568

DSS_SCORE: 0.8191

HELIX: 0.1008

FCONS_SCORE: 0.9733

RIG_SCORE: 0.5123

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A473P	TCGA-44-2656	LUAD	TCGA	DSGTSS	DEG_SCF_TRCP1_1	0.3056
p.A473P	DO26052	LUAD	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.3056
p.Q480H	TCGA-78-7540	LUAD	TCGA	DSGTSS	DEG_SCF_TRCP1_1	0.1111
p.Q480H	DO23810	LUAD	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.1111
p.A462S	TCGA-A6-5661	COAD	TCGA	DSGTSS	DEG_SCF_TRCP1_1	0.1944
p.A462S	DO8634	COAD	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.1944
p.G482V	TCGA-ER-A19G	SKCM	TCGA	DSGTSS	DEG_SCF_TRCP1_1	0.0556
p.G482V	DO47284	SKCM	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.0556
p.S468Y	TCGA-F5-6814	READ	TCGA	DSGTSS	DEG_SCF_TRCP1_1	0.712
p.S468Y	DO36556	READ	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.712
p.A459T	TCGA-HZ-A49I	PAAD	TCGA	DSGTSS	DEG_SCF_TRCP1_1	0.1111
p.A459T	TCGA-KK-A5A1	PRAD	TCGA	DSGTSS	DEG_SCF_TRCP1_1	0.1111
p.A459T	TCGA-KV-A74V	KIRP	TCGA	DSGTSS	DEG_SCF_TRCP1_1	0.1111
p.A459T	DO48480	KIRP	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.1111
p.A459T	DO32790	PAAD	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.1111
p.A459T	DO49845	PRAD	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.1111
p.T479A	TCGA-KR-A7K0	LIHC	TCGA	DSGTSS	DEG_SCF_TRCP1_1	0.1389
p.T479A	DO49696	LIHC	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.1389
p.P463H	TCGA-KV-A74V	KIRP	TCGA	DSGTSS	DEG_SCF_TRCP1_1	0.2222
p.P463H	DO48480	KIRP	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.2222
p.A473V	TCGA-Z7-A8R6	BRCA	TCGA	DSGTSS	DEG_SCF_TRCP1_1	0.3056
p.A473V	DO51231	BRCA	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.3056
p.G482R	DO52651	MALY	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.0556
p.P458S	DO222418	MELA	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.0833
p.P466L	SIDM01004	Chronic Myelogenous Leukemia	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.3056
p.P466L	ACH-000983	Leukemia	CCLE	DSGTSS	DEG_SCF_TRCP1_1	0.3056
p.P466L	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	DSGTSS	DEG_SCF_TRCP1_1	0.3056
p.A462T	SIDM00216	Colorectal Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.1944
p.A462T	ACH-000989	Colon/Colorectal Cancer	CCLE	DSGTSS	DEG_SCF_TRCP1_1	0.1944
p.A462T	SNU-175	large_intestine	COSMIC	DSGTSS	DEG_SCF_TRCP1_1	0.1944
p.G469V	SIDM00705	Non-Cancerous	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.7532
p.G469V	SIDM00712	Non-Cancerous	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.7532
p.G469V	SIDM00696	Non-Cancerous	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.7532
p.G469V	SIDM00772	Breast Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.7532
p.G469V	SIDM00713	Mesothelioma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.7532
p.G469V	SIDM00792	Small Cell Lung Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.7532
p.G482E	SIDM01059	Melanoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.0556
p.G482E	ACH-000915	Skin Cancer	CCLE	DSGTSS	DEG_SCF_TRCP1_1	0.0556
p.G482E	IPC-298	skin	COSMIC	DSGTSS	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A5PKW4	PH and SEC7 domain-containing protein 1	DEG_SCF_TRCP1_1	467:472	DSGTSS	BTRC	0.8696	More...
O94901	SUN domain-containing protein 1	DEG_SCF_TRCP1_1	74:79	DSGTSS	BTRC	0.9911	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SCF_TRCP1_1	248:253	DSGTSS	BTRC	0.9889	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGTSS

Degron related mutations and impact score

Drug responses associated with PSD mutations

All proteins holding degron of DSGTSS