DegronMD - A5PKW4(PSD)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A473P	TCGA-44-2656	LUAD	TCGA	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.3056
p.A473P	DO26052	LUAD	ICGC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.3056
p.S190Y	TCGA-55-A4DF	LUAD	TCGA	DGLYSSLP	CBL_PTK	186:193	Mutation altering degron motif	0.712
p.S190Y	DO45318	LUAD	ICGC	DGLYSSLP	CBL_PTK	186:193	Mutation altering degron motif	0.712
p.Q480H	TCGA-78-7540	LUAD	TCGA	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.1111
p.Q480H	DO23810	LUAD	ICGC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.1111
p.A462S	TCGA-A6-5661	COAD	TCGA	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.1944
p.A462S	DO8634	COAD	ICGC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.1944
p.G198A	TCGA-AX-A1C5	UCEC	TCGA	DGLYSSLP	CBL_PTK	186:193	Mutation rewiring degron network	0.1944
p.G198A	DO41422	UCEC	ICGC	DGLYSSLP	CBL_PTK	186:193	Mutation rewiring degron network	0.1944
p.G198A	SIDM01278	Colorectal Carcinoma	GDSC	DGLYSSLP	CBL_PTK	186:193	Mutation rewiring degron network	0.1944
p.S191F	TCGA-ER-A19F	SKCM	TCGA	DGLYSSLP	CBL_PTK	186:193	Mutation altering degron motif	0.6871
p.S191F	DO37679	SKCM	ICGC	DGLYSSLP	CBL_PTK	186:193	Mutation altering degron motif	0.6871
p.G482V	TCGA-ER-A19G	SKCM	TCGA	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.0556
p.G482V	DO47284	SKCM	ICGC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.0556
p.S468Y	TCGA-F5-6814	READ	TCGA	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation altering degron motif	0.712
p.S468Y	DO36556	READ	ICGC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation altering degron motif	0.712
p.P193T	TCGA-FS-A1ZB	SKCM	TCGA	DGLYSSLP	CBL_PTK	186:193	Mutation altering degron motif	0.7031
p.P193T	DO37886	SKCM	ICGC	DGLYSSLP	CBL_PTK	186:193	Mutation altering degron motif	0.7031
p.A459T	TCGA-HZ-A49I	PAAD	TCGA	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.1111
p.A459T	TCGA-KK-A5A1	PRAD	TCGA	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.1111
p.A459T	TCGA-KV-A74V	KIRP	TCGA	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.1111
p.A459T	DO48480	KIRP	ICGC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.1111
p.A459T	DO32790	PAAD	ICGC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.1111
p.A459T	DO49845	PRAD	ICGC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.1111
p.T479A	TCGA-KR-A7K0	LIHC	TCGA	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.1389
p.T479A	DO49696	LIHC	ICGC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.1389
p.P463H	TCGA-KV-A74V	KIRP	TCGA	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.2222
p.P463H	DO48480	KIRP	ICGC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.2222
p.A473V	TCGA-Z7-A8R6	BRCA	TCGA	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.3056
p.A473V	DO51231	BRCA	ICGC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.3056
p.G198S	DO234151	ESAD	ICGC	DGLYSSLP	CBL_PTK	186:193	Mutation rewiring degron network	0.1944
p.R202S	DO229038	LICA	ICGC	DGLYSSLP	CBL_PTK	186:193	Mutation rewiring degron network	0.0833
p.R202C	DO27805	MALY	ICGC	DGLYSSLP	CBL_PTK	186:193	Mutation rewiring degron network	0.0833
p.G482R	DO52651	MALY	ICGC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.0556
p.P458S	DO222418	MELA	ICGC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.0833
p.P466L	SIDM01004	Chronic Myelogenous Leukemia	GDSC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.3056
p.P466L	ACH-000983	Leukemia	CCLE	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.3056
p.P466L	KCL-22	haematopoietic and lymphoid tissue	COSMIC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.3056
p.G198D	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DGLYSSLP	CBL_PTK	186:193	Mutation rewiring degron network	0.1944
p.G198D	ACH-000981	Leukemia	CCLE	DGLYSSLP	CBL_PTK	186:193	Mutation rewiring degron network	0.1944
p.A462T	SIDM00216	Colorectal Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.1944
p.A462T	ACH-000989	Colon/Colorectal Cancer	CCLE	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.1944
p.A462T	SNU-175	large intestine	COSMIC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.1944
p.G469V	SIDM00705	Non-Cancerous	GDSC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation altering degron motif	0.7532
p.G469V	SIDM00712	Non-Cancerous	GDSC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation altering degron motif	0.7532
p.G469V	SIDM00696	Non-Cancerous	GDSC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation altering degron motif	0.7532
p.G469V	SIDM00772	Breast Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation altering degron motif	0.7532
p.G469V	SIDM00713	Mesothelioma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation altering degron motif	0.7532
p.G469V	SIDM00792	Small Cell Lung Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation altering degron motif	0.7532
p.G482E	SIDM01059	Melanoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.0556
p.G482E	ACH-000915	Skin Cancer	CCLE	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.0556
p.G482E	IPC-298	skin	COSMIC	DSGTSS	DEG_SCF_TRCP1_1	467:472	Mutation rewiring degron network	0.0556
p.A179V	SNU-1040	large intestine	COSMIC	DGLYSSLP	CBL_PTK	186:193	Mutation rewiring degron network	0.1389
p.A179T	GP5d	large intestine	COSMIC	DGLYSSLP	CBL_PTK	186:193	Mutation rewiring degron network	0.1389
p.G202C	WM1552C	skin	COSMIC	DGLYSSLP	CBL_PTK	186:193	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PSD

UniProt ID: A5PKW4

Entrez ID: 5662

Protein name: PH and SEC7 domain-containing protein 1 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Exchange factor for ARF6) (Exchange factor for ARF6 A) (Pleckstrin homology and SEC7 domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PSD in