DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
DGLYSSLP
Uniprot ID:
A5PKW4
Source protein:
PH and SEC7 domain-containing protein 1
Source gene:
PSD
Class:
CBL_PTK
Location:
186:193
E3 ligase:
CBL
DEGRON score:
0.8883
ASA_SCORE:
59.975
COIL:
0.7176
CONS_SCORE:
0.2992
DSS_SCORE:
0.5675
HELIX:
0.1516
FCONS_SCORE:
1.0377
RIG_SCORE:
0.6809
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S190Y
TCGA-55-A4DF
LUAD
TCGA
DGLYSSLP
CBL_PTK
0.712
p.S190Y
DO45318
LUAD
ICGC
DGLYSSLP
CBL_PTK
0.712
p.G198A
TCGA-AX-A1C5
UCEC
TCGA
DGLYSSLP
CBL_PTK
0.1944
p.G198A
DO41422
UCEC
ICGC
DGLYSSLP
CBL_PTK
0.1944
p.G198A
SIDM01278
Colorectal Carcinoma
GDSC
DGLYSSLP
CBL_PTK
0.1944
p.S191F
TCGA-ER-A19F
SKCM
TCGA
DGLYSSLP
CBL_PTK
0.6871
p.S191F
DO37679
SKCM
ICGC
DGLYSSLP
CBL_PTK
0.6871
p.P193T
TCGA-FS-A1ZB
SKCM
TCGA
DGLYSSLP
CBL_PTK
0.7031
p.P193T
DO37886
SKCM
ICGC
DGLYSSLP
CBL_PTK
0.7031
p.G198S
DO234151
ESAD
ICGC
DGLYSSLP
CBL_PTK
0.1944
p.R202S
DO229038
LICA
ICGC
DGLYSSLP
CBL_PTK
0.0833
p.R202C
DO27805
MALY
ICGC
DGLYSSLP
CBL_PTK
0.0833
p.G198D
SIDM00946
T-Lymphoblastic Leukemia
GDSC
DGLYSSLP
CBL_PTK
0.1944
p.G198D
ACH-000981
Leukemia
CCLE
DGLYSSLP
CBL_PTK
0.1944
p.A179V
SNU-1040
large_intestine
COSMIC
DGLYSSLP
CBL_PTK
0.1389
p.A179T
GP5d
large_intestine
COSMIC
DGLYSSLP
CBL_PTK
0.1389
p.G202C
WM1552C
skin
COSMIC
DGLYSSLP
CBL_PTK
0.0833
Drug responses associated with PSD mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DGLYSSLP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A5PKW4
PH and SEC7 domain-containing protein 1
CBL_PTK
186:193
DGLYSSLP
CBL
0.8883
More...