DegronMD

Degron: DGLYSSLP

Uniprot ID: A5PKW4

Source protein: PH and SEC7 domain-containing protein 1

Source gene: PSD

Class: CBL_PTK

Location: 186:193

E3 ligase: CBL

DEGRON score: 0.8883

ASA_SCORE: 59.975

COIL: 0.7176

CONS_SCORE: 0.2992

DSS_SCORE: 0.5675

HELIX: 0.1516

FCONS_SCORE: 1.0377

RIG_SCORE: 0.6809

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S190Y	TCGA-55-A4DF	LUAD	TCGA	DGLYSSLP	CBL_PTK	0.712
p.S190Y	DO45318	LUAD	ICGC	DGLYSSLP	CBL_PTK	0.712
p.P193T	TCGA-FS-A1ZB	SKCM	TCGA	DGLYSSLP	CBL_PTK	0.7031
p.P193T	DO37886	SKCM	ICGC	DGLYSSLP	CBL_PTK	0.7031
p.S191F	TCGA-ER-A19F	SKCM	TCGA	DGLYSSLP	CBL_PTK	0.6871
p.S191F	DO37679	SKCM	ICGC	DGLYSSLP	CBL_PTK	0.6871
p.G198A	TCGA-AX-A1C5	UCEC	TCGA	DGLYSSLP	CBL_PTK	0.1944
p.G198A	DO41422	UCEC	ICGC	DGLYSSLP	CBL_PTK	0.1944
p.G198A	SIDM01278	Colorectal Carcinoma	GDSC	DGLYSSLP	CBL_PTK	0.1944
p.G198S	DO234151	ESAD	ICGC	DGLYSSLP	CBL_PTK	0.1944
p.G198D	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DGLYSSLP	CBL_PTK	0.1944
p.G198D	ACH-000981	Leukemia	CCLE	DGLYSSLP	CBL_PTK	0.1944
p.A179V	SNU-1040	large_intestine	COSMIC	DGLYSSLP	CBL_PTK	0.1389
p.A179T	GP5d	large_intestine	COSMIC	DGLYSSLP	CBL_PTK	0.1389
p.R202S	DO229038	LICA	ICGC	DGLYSSLP	CBL_PTK	0.0833
p.R202C	DO27805	MALY	ICGC	DGLYSSLP	CBL_PTK	0.0833
p.G202C	WM1552C	skin	COSMIC	DGLYSSLP	CBL_PTK	0.0833

Showing 1 to 17 of 17 entries

Drug responses associated with PSD mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

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All proteins holding degron of DGLYSSLP

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A5PKW4	PH and SEC7 domain-containing protein 1	CBL_PTK	186:193	DGLYSSLP	CBL	0.8883	More...

Showing 1 to 1 of 1 entries