DegronMD

Uniprot ID: O94901

Source protein: SUN domain-containing protein 1

Source gene: SUN1

Class: DEG_SCF_TRCP1_1

Location: 74:79

E3 ligase: BTRC

DEGRON score: 0.9911

ASA_SCORE: 65.5833

COIL: 0.8248

CONS_SCORE: 0.2624

DSS_SCORE: 0.4552

HELIX: 0.1252

FCONS_SCORE: 0.9576

RIG_SCORE: 0.6652

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E75Q	DO856	BLCA	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.6744
p.V81A	DO220823	BRCA	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.2778
p.Y67H	DO219724	CESC	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.1389
p.P70L	DO219106	COAD	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.2222
p.D67N	DO222358	LICA	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.1389
p.T80R	DO28249	OV	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.3056
p.P69L	DO47569	SKCM	ICGC	DSGTSS	DEG_SCF_TRCP1_1	0.1944
p.R86Q	SIDM00672	Hepatocellular Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.1389
p.R86Q	ACH-000625	Liver Cancer	CCLE	DSGTSS	DEG_SCF_TRCP1_1	0.1389
p.R86Q	Hep_3B2_1-7	NS	COSMIC	DSGTSS	DEG_SCF_TRCP1_1	0.1389
p.R86P	SIDM00002	Neuroblastoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.1389
p.R86P	SIDM01180	Hepatocellular Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.1389
p.R86P	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.1389
p.R86P	SIDM01413	Oral Cavity Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.1389
p.R86P	HCC-15	lung	COSMIC	DSGTSS	DEG_SCF_TRCP1_1	0.1389
p.R86P	SNU-387	liver	COSMIC	DSGTSS	DEG_SCF_TRCP1_1	0.1389
p.R86P	NBsusSR	autonomic_ganglia	COSMIC	DSGTSS	DEG_SCF_TRCP1_1	0.1389
p.S79G	SIDM00518	Mesothelioma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.8104
p.S79G	SIDM01050	Biliary Tract Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.8104
p.G68D	SIDM00488	Colorectal Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.1667
p.G68D	SIDM01146	Gastric Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.1667
p.G68D	SIDM00988	Kidney Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.1667
p.G76A	SIDM00576	Acute Myeloid Leukemia	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.754
p.G76A	SIDM01449	Pancreatic Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.754
p.G76A	SIDM01471	Chronic Myelogenous Leukemia	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.754
p.G76A	SIDM01685	B-Lymphoblastic Leukemia	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.754
p.G76A	SIDM01753	Gastric Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.754
p.G76C	SIDM01318	Hepatocellular Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	0.76
p.G76D	ACH-001970	Metastasis	CCLE	DSGTSS	DEG_SCF_TRCP1_1	0.7198
p.T79I	BT-483	breast	COSMIC	DSGTSS	DEG_SCF_TRCP1_1	0.7078
p.R74H	GP5d	large_intestine	COSMIC	DSGTSS	DEG_SCF_TRCP1_1	0.8244
p.V66A	LNCaP-Clone-FGC	prostate	COSMIC	DSGTSS	DEG_SCF_TRCP1_1	0.1111
p.T71A	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	DSGTSS	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A5PKW4	PH and SEC7 domain-containing protein 1	DEG_SCF_TRCP1_1	467:472	DSGTSS	BTRC	0.8696	More...
O94901	SUN domain-containing protein 1	DEG_SCF_TRCP1_1	74:79	DSGTSS	BTRC	0.9911	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SCF_TRCP1_1	248:253	DSGTSS	BTRC	0.9889	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGTSS

Degron related mutations and impact score

Drug responses associated with SUN1 mutations

All proteins holding degron of DSGTSS