DegronMD - O94901(SUN1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E75Q	DO856	BLCA	ICGC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation altering degron motif	0.6744
p.V81A	DO220823	BRCA	ICGC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation rewiring degron network	0.2778
p.Y67H	DO219724	CESC	ICGC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation rewiring degron network	0.1389
p.P70L	DO219106	COAD	ICGC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation rewiring degron network	0.2222
p.D67N	DO222358	LICA	ICGC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation rewiring degron network	0.1389
p.T80R	DO28249	OV	ICGC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation rewiring degron network	0.3056
p.P69L	DO47569	SKCM	ICGC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation rewiring degron network	0.1944
p.R86Q	SIDM00672	Hepatocellular Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation rewiring degron network	0.1389
p.R86Q	ACH-000625	Liver Cancer	CCLE	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation rewiring degron network	0.1389
p.R86Q	Hep_3B2_1-7	NS	COSMIC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation rewiring degron network	0.1389
p.R86P	SIDM00002	Neuroblastoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation rewiring degron network	0.1389
p.R86P	SIDM01180	Hepatocellular Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation rewiring degron network	0.1389
p.R86P	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation rewiring degron network	0.1389
p.R86P	SIDM01413	Oral Cavity Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation rewiring degron network	0.1389
p.R86P	HCC-15	lung	COSMIC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation rewiring degron network	0.1389
p.R86P	SNU-387	liver	COSMIC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation rewiring degron network	0.1389
p.R86P	NBsusSR	autonomic ganglia	COSMIC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation rewiring degron network	0.1389
p.S79G	SIDM00518	Mesothelioma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation altering degron motif	0.8104
p.S79G	SIDM01050	Biliary Tract Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation altering degron motif	0.8104
p.G68D	SIDM00488	Colorectal Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation rewiring degron network	0.1667
p.G68D	SIDM01146	Gastric Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation rewiring degron network	0.1667
p.G68D	SIDM00988	Kidney Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation rewiring degron network	0.1667
p.G76A	SIDM00576	Acute Myeloid Leukemia	GDSC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation altering degron motif	0.754
p.G76A	SIDM01449	Pancreatic Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation altering degron motif	0.754
p.G76A	SIDM01471	Chronic Myelogenous Leukemia	GDSC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation altering degron motif	0.754
p.G76A	SIDM01685	B-Lymphoblastic Leukemia	GDSC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation altering degron motif	0.754
p.G76A	SIDM01753	Gastric Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation altering degron motif	0.754
p.G76C	SIDM01318	Hepatocellular Carcinoma	GDSC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation altering degron motif	0.76
p.G76D	ACH-001970	Metastasis	CCLE	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation altering degron motif	0.7198
p.T79I	BT-483	breast	COSMIC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation altering degron motif	0.7078
p.R74H	GP5d	large intestine	COSMIC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation altering degron motif	0.8244
p.V66A	LNCaP-Clone-FGC	prostate	COSMIC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation rewiring degron network	0.1111
p.T71A	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	DSGTSS	DEG_SCF_TRCP1_1	74:79	Mutation rewiring degron network	0.25

Kaplan plot for SUN1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SUN1

UniProt ID: O94901

Entrez ID: 23353

Protein name: SUN domain-containing protein 1 (Protein unc-84 homolog A) (Sad1/unc-84 protein-like 1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SUN1 in