DegronMD - Q9UBC2(EPS15L1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q542K	TCGA-09-2044	OV	TCGA	ARSKLSQLH	DEG_APCC_DBOX_1	543:551	Mutation rewiring degron network	0.3056
p.S548F	TCGA-44-6144	LUAD	TCGA	ARSKLSQLH	DEG_APCC_DBOX_1	543:551	Mutation altering degron motif	0.7982
p.S548F	TCGA-D3-A8GI	SKCM	TCGA	ARSKLSQLH	DEG_APCC_DBOX_1	543:551	Mutation altering degron motif	0.7982
p.R544S	TCGA-60-2714	LUSC	TCGA	ARSKLSQLH	DEG_APCC_DBOX_1	543:551	Mutation altering degron motif	0.7427
p.R544S	DO26530	LUSC	ICGC	ARSKLSQLH	DEG_APCC_DBOX_1	543:551	Mutation altering degron motif	0.7427
p.E539K	TCGA-AA-3984	COAD	TCGA	ARSKLSQLH	DEG_APCC_DBOX_1	543:551	Mutation rewiring degron network	0.2222
p.E539K	TCGA-BR-8680	STAD	TCGA	ARSKLSQLH	DEG_APCC_DBOX_1	543:551	Mutation rewiring degron network	0.2222
p.E539K	DO9002	COAD	ICGC	ARSKLSQLH	DEG_APCC_DBOX_1	543:551	Mutation rewiring degron network	0.2222
p.E539K	DO47769	STAD	ICGC	ARSKLSQLH	DEG_APCC_DBOX_1	543:551	Mutation rewiring degron network	0.2222
p.E552G	TCGA-B9-5155	KIRP	TCGA	ARSKLSQLH	DEG_APCC_DBOX_1	543:551	Mutation rewiring degron network	0.3056
p.E552G	DO20843	KIRP	ICGC	ARSKLSQLH	DEG_APCC_DBOX_1	543:551	Mutation rewiring degron network	0.3056
p.P755S	TCGA-DA-A1I5	SKCM	TCGA	PFTSS	DEG_SPOP_SBC_1	755:759	Mutation altering degron motif	0.6752
p.P755S	DO37447	SKCM	ICGC	PFTSS	DEG_SPOP_SBC_1	755:759	Mutation altering degron motif	0.6752
p.S708N	TCGA-DF-A2KU	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	710:714	Mutation blocking phosphorylation signal	0.7222
p.S708N	DO223286	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	710:714	Mutation blocking phosphorylation signal	0.7222
p.P723L	TCGA-EE-A2GC	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	710:714	Mutation rewiring degron network	0.0833
p.P723L	TCGA-ER-A19J	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	710:714	Mutation rewiring degron network	0.0833
p.P723L	DO37839	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	710:714	Mutation rewiring degron network	0.0833
p.P723L	DO37426	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	710:714	Mutation rewiring degron network	0.0833
p.D703N	TCGA-EO-A22R	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	710:714	Mutation rewiring degron network	0.1389
p.D703N	DO234353	ESAD	ICGC	PFSSS	DEG_SPOP_SBC_1	710:714	Mutation rewiring degron network	0.1389
p.D703N	DO42713	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	710:714	Mutation rewiring degron network	0.1389
p.S700L	TCGA-EO-A22U	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	710:714	Mutation rewiring degron network	0.0556
p.S700L	DO43755	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	710:714	Mutation rewiring degron network	0.0556
p.P710S	TCGA-FR-A726	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	710:714	Mutation altering degron motif	0.6752
p.P710S	DO48665	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	710:714	Mutation altering degron motif	0.6752
p.S717F	TCGA-W3-A824	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	710:714	Mutation blocking phosphorylation signal	0.6944
p.S717F	DO51271	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	710:714	Mutation blocking phosphorylation signal	0.6944
p.Q746H	DO225213	BRCA	ICGC	PFTSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.0833
p.Q746H	DO227529	BRCA	ICGC	PFTSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.0833
p.S712L	DO49009	CESC	ICGC	PFSSS	DEG_SPOP_SBC_1	710:714	Mutation altering degron motif	0.8778
p.S745R	DO229019	LICA	ICGC	PFTSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.0556
p.D768E	DO229006	LICA	ICGC	PFTSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.0833
p.D768E	DO229259	THCA	ICGC	PFTSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.0833
p.S707C	DO33000	PACA	ICGC	PFSSS	DEG_SPOP_SBC_1	710:714	Mutation blocking phosphorylation signal	0.6944
p.A763T	SIDM00845	Burkitt's Lymphoma	GDSC	PFTSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.2222
p.A763T	ACH-000786	Lymphoma	CCLE	PFTSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.2222
p.R554C	SIDM00342	T-Lymphoblastic Leukemia	GDSC	ARSKLSQLH	DEG_APCC_DBOX_1	543:551	Mutation rewiring degron network	0.25
p.R554C	LOUCY	haematopoietic and lymphoid tissue	COSMIC	ARSKLSQLH	DEG_APCC_DBOX_1	543:551	Mutation rewiring degron network	0.25
p.S548Y	ACH-001408	Bladder Cancer	CCLE	ARSKLSQLH	DEG_APCC_DBOX_1	543:551	Mutation altering degron motif	0.712

Kaplan plot for EPS15L1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EPS15L1

UniProt ID: Q9UBC2

Entrez ID: 58513

Protein name: Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EPS15L1 in