DegronMD

Uniprot ID: Q9UBC2

Source protein: Epidermal growth factor receptor substrate 15-like 1

Source gene: EPS15L1

Class: DEG_APCC_DBOX_1

Location: 543:551

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8871

ASA_SCORE: 92.4

COIL: 0.1837

CONS_SCORE: 0.5287

DSS_SCORE: 0.5449

HELIX: 0.8186

FCONS_SCORE: 1.0877

RIG_SCORE: 0.6994

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q542K	TCGA-09-2044	OV	TCGA	ARSKLSQLH	DEG_APCC_DBOX_1	0.3056
p.S548F	TCGA-44-6144	LUAD	TCGA	ARSKLSQLH	DEG_APCC_DBOX_1	0.7982
p.S548F	TCGA-D3-A8GI	SKCM	TCGA	ARSKLSQLH	DEG_APCC_DBOX_1	0.7982
p.R544S	TCGA-60-2714	LUSC	TCGA	ARSKLSQLH	DEG_APCC_DBOX_1	0.7427
p.R544S	DO26530	LUSC	ICGC	ARSKLSQLH	DEG_APCC_DBOX_1	0.7427
p.E539K	TCGA-AA-3984	COAD	TCGA	ARSKLSQLH	DEG_APCC_DBOX_1	0.2222
p.E539K	TCGA-BR-8680	STAD	TCGA	ARSKLSQLH	DEG_APCC_DBOX_1	0.2222
p.E539K	DO9002	COAD	ICGC	ARSKLSQLH	DEG_APCC_DBOX_1	0.2222
p.E539K	DO47769	STAD	ICGC	ARSKLSQLH	DEG_APCC_DBOX_1	0.2222
p.E552G	TCGA-B9-5155	KIRP	TCGA	ARSKLSQLH	DEG_APCC_DBOX_1	0.3056
p.E552G	DO20843	KIRP	ICGC	ARSKLSQLH	DEG_APCC_DBOX_1	0.3056
p.R554C	SIDM00342	T-Lymphoblastic Leukemia	GDSC	ARSKLSQLH	DEG_APCC_DBOX_1	0.25
p.R554C	LOUCY	haematopoietic_and_lymphoid_tissue	COSMIC	ARSKLSQLH	DEG_APCC_DBOX_1	0.25
p.S548Y	ACH-001408	Bladder Cancer	CCLE	ARSKLSQLH	DEG_APCC_DBOX_1	0.712

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	DEG_APCC_DBOX_1	543:551	ARSKLSQLH	APC,CDC20,FZR1	0.8871	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons