DegronMD

Uniprot ID: P41162

Source protein: ETS translocation variant 3

Source gene: ETV3

Class: DEG_SCF_FBW7_2

Location: 436:443

E3 ligase: FBXW7

DEGRON score: 0.9987

ASA_SCORE: 78.9375

COIL: 0.9509

CONS_SCORE: 0.4047

DSS_SCORE: 0.667

HELIX: 0.0215

FCONS_SCORE: 1.1966

RIG_SCORE: 0.5926

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I437V	TCGA-AP-A1DK	UCEC	TCGA	PISTPSGE	DEG_SCF_FBW7_2	0.5965
p.I437V	DO42033	UCEC	ICGC	PISTPSGE	DEG_SCF_FBW7_2	0.5965
p.P440S	TCGA-DF-A2KN	UCEC	TCGA	PISTPSGE	DEG_SCF_FBW7_2	0.6752
p.P440S	DO223282	UCEC	ICGC	PISTPSGE	DEG_SCF_FBW7_2	0.6752
p.P430T	DO228948	LICA	ICGC	PISTPSGE	DEG_SCF_FBW7_2	0.1667
p.D450Y	SIDM00807	Bladder Carcinoma	GDSC	PISTPSGE	DEG_SCF_FBW7_2	0.1389
p.D450Y	ACH-000905	Bladder Cancer	CCLE	PISTPSGE	DEG_SCF_FBW7_2	0.1389
p.D450Y	5637	urinary_tract	COSMIC	PISTPSGE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41162	ETS translocation variant 3	DEG_SCF_FBW7_2	436:443	PISTPSGE	FBXW7	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons