DegronMD

Uniprot ID: Q86UU0

Source protein: B-cell CLL/lymphoma 9-like protein

Source gene: BCL9L

Class: DEG_SCF_FBW7_1

Location: 353:359

E3 ligase: FBXW7

DEGRON score: 0.8767

ASA_SCORE: 99.4286

COIL: 0.9717

CONS_SCORE: 0.6025

DSS_SCORE: 0.7858

HELIX: 0.0141

FCONS_SCORE: 0.9906

RIG_SCORE: 0.6132

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P356L	TCGA-AA-A01R	COAD	TCGA	PNTPTAT	DEG_SCF_FBW7_1	0.7582
p.P356L	DO7934	COAD	ICGC	PNTPTAT	DEG_SCF_FBW7_1	0.7582
p.A361T	TCGA-VQ-A8PB	STAD	TCGA	PNTPTAT	DEG_SCF_FBW7_1	0.2778
p.A361T	DO51766	STAD	ICGC	PNTPTAT	DEG_SCF_FBW7_1	0.2778
p.G349R	DO50743	LICA	ICGC	PNTPTAT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UU0	B-cell CLL/lymphoma 9-like protein	DEG_SCF_FBW7_1	353:359	PNTPTAT	FBXW7	0.8767	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons