DegronMD

Uniprot ID: Q86UU0

Source protein: B-cell CLL/lymphoma 9-like protein

Source gene: BCL9L

Class: DEG_SIAH_1

Location: 96:104

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9927

ASA_SCORE: 83.9444

COIL: 0.9516

CONS_SCORE: 0.6198

DSS_SCORE: 0.6291

HELIX: 0.0241

FCONS_SCORE: 0.7533

RIG_SCORE: 0.6272

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A99V	TCGA-A2-A4S2	BRCA	TCGA	NPQAGVPPF	DEG_SIAH_1	0.6936
p.A99V	DO44184	BRCA	ICGC	NPQAGVPPF	DEG_SIAH_1	0.6936
p.G109S	TCGA-BH-A1FL	BRCA	TCGA	NPQAGVPPF	DEG_SIAH_1	0.1944
p.G109S	DO5221	BRCA	ICGC	NPQAGVPPF	DEG_SIAH_1	0.1944
p.Q98R	TCGA-GC-A3YS	BLCA	TCGA	NPQAGVPPF	DEG_SIAH_1	0.6218
p.Q98R	DO850	BLCA	ICGC	NPQAGVPPF	DEG_SIAH_1	0.6218
p.P103H	TCGA-L5-A43J	ESCA	TCGA	NPQAGVPPF	DEG_SIAH_1	0.7694
p.L94V	DO222489	ESCA	ICGC	NPQAGVPPF	DEG_SIAH_1	0.2778
p.N96S	DO233867	GACA	ICGC	NPQAGVPPF	DEG_SIAH_1	0.5958
p.P102T	DO229026	LICA	ICGC	NPQAGVPPF	DEG_SIAH_1	0.5919
p.G109D	DO35406	PACA	ICGC	NPQAGVPPF	DEG_SIAH_1	0.1944
p.P97L	SIDM00177	Melanoma	GDSC	NPQAGVPPF	DEG_SIAH_1	0.7582
p.L112V	SK-GT-4	oesophagus	COSMIC	NPQAGVPPF	DEG_SIAH_1	0.2222
p.R109C	SNU-1040	large_intestine	COSMIC	NPQAGVPPF	DEG_SIAH_1	0.1944
p.R114P	NCI-H1299	lung	COSMIC	NPQAGVPPF	DEG_SIAH_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UU0	B-cell CLL/lymphoma 9-like protein	DEG_SIAH_1	96:104	NPQAGVPPF	SIAH1,SIAH2,SIAH3	0.9927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons