DegronMD

Uniprot ID: Q86UU0

Source protein: B-cell CLL/lymphoma 9-like protein

Source gene: BCL9L

Class: DEG_Kelch_Keap1_1

Location: 118:123

E3 ligase: KEAP1

DEGRON score: 0.989

ASA_SCORE: 84.2667

COIL: 0.9178

CONS_SCORE: 0.7999

DSS_SCORE: 0.6511

HELIX: 0.0388

FCONS_SCORE: 0.9801

RIG_SCORE: 0.6299

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G109S	TCGA-BH-A1FL	BRCA	TCGA	SVDSGE	DEG_Kelch_Keap1_1	0.0833
p.G109S	DO5221	BRCA	ICGC	SVDSGE	DEG_Kelch_Keap1_1	0.0833
p.P130S	TCGA-CN-5355	HNSC	TCGA	SVDSGE	DEG_Kelch_Keap1_1	0.1389
p.P130S	DO14638	HNSC	ICGC	SVDSGE	DEG_Kelch_Keap1_1	0.1389
p.R125Q	TCGA-MX-A5UJ	STAD	TCGA	SVDSGE	DEG_Kelch_Keap1_1	0.2778
p.R125Q	DO48547	STAD	ICGC	SVDSGE	DEG_Kelch_Keap1_1	0.2778
p.Q124K	DO229028	LICA	ICGC	SVDSGE	DEG_Kelch_Keap1_1	0.3056
p.S118Y	DO229035	LICA	ICGC	SVDSGE	DEG_Kelch_Keap1_1	0.8231
p.D120E	DO229008	LICA	ICGC	SVDSGE	DEG_Kelch_Keap1_1	0.5647
p.G109D	DO35406	PACA	ICGC	SVDSGE	DEG_Kelch_Keap1_1	0.0833
p.L112V	SK-GT-4	oesophagus	COSMIC	SVDSGE	DEG_Kelch_Keap1_1	0.2778
p.R109C	SNU-1040	large_intestine	COSMIC	SVDSGE	DEG_Kelch_Keap1_1	0.0833
p.R114P	NCI-H1299	lung	COSMIC	SVDSGE	DEG_Kelch_Keap1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UU0	B-cell CLL/lymphoma 9-like protein	DEG_Kelch_Keap1_1	118:123	SVDSGE	KEAP1	0.989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons