DegronMD

Uniprot ID: Q86UU0

Source protein: B-cell CLL/lymphoma 9-like protein

Source gene: BCL9L

Class: DEG_COP1_1

Location: 997:1005

E3 ligase: COP1

DEGRON score: 0.9893

ASA_SCORE: 84.4333

COIL: 0.9677

CONS_SCORE: 0.8316

DSS_SCORE: 0.5636

HELIX: 0.0176

FCONS_SCORE: 0.9361

RIG_SCORE: 0.5939

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R994M	TCGA-21-1082	LUSC	TCGA	SPSMAVPSP	DEG_COP1_1	0.25
p.R994M	DO26463	LUSC	ICGC	SPSMAVPSP	DEG_COP1_1	0.25
p.P998H	TCGA-A5-A0G2	UCEC	TCGA	SPSMAVPSP	DEG_COP1_1	0.6583
p.P998H	DO41235	UCEC	ICGC	SPSMAVPSP	DEG_COP1_1	0.6583
p.A1001V	TCGA-EY-A549	UCEC	TCGA	SPSMAVPSP	DEG_COP1_1	0.5825
p.A1001V	TCGA-XK-AAIW	PRAD	TCGA	SPSMAVPSP	DEG_COP1_1	0.5825
p.A1001V	DO51407	PRAD	ICGC	SPSMAVPSP	DEG_COP1_1	0.5825
p.A1001V	DO48174	UCEC	ICGC	SPSMAVPSP	DEG_COP1_1	0.5825
p.A1001V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	SPSMAVPSP	DEG_COP1_1	0.5825
p.A1001V	SIDM00980	Gastric Carcinoma	GDSC	SPSMAVPSP	DEG_COP1_1	0.5825
p.A1001V	ACH-000948	Gastric Cancer	CCLE	SPSMAVPSP	DEG_COP1_1	0.5825
p.A1001V	ACH-001127	Leukemia	CCLE	SPSMAVPSP	DEG_COP1_1	0.5825
p.A1001V	23132-87	stomach	COSMIC	SPSMAVPSP	DEG_COP1_1	0.5825
p.A1001V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	SPSMAVPSP	DEG_COP1_1	0.5825
p.S991L	TCGA-FS-A4F5	SKCM	TCGA	SPSMAVPSP	DEG_COP1_1	0.6111
p.S991L	DO37881	SKCM	ICGC	SPSMAVPSP	DEG_COP1_1	0.6111
p.G1006S	DO233216	GACA	ICGC	SPSMAVPSP	DEG_COP1_1	0.3056
p.P1011T	DO229037	LICA	ICGC	SPSMAVPSP	DEG_COP1_1	0.1667
p.A1009V	SIDM00999	Bladder Carcinoma	GDSC	SPSMAVPSP	DEG_COP1_1	0.2222
p.A1009V	ACH-000973	Bladder Cancer	CCLE	SPSMAVPSP	DEG_COP1_1	0.2222
p.A1009V	639-V	urinary_tract	COSMIC	SPSMAVPSP	DEG_COP1_1	0.2222
p.R1013W	LS-411N	large_intestine	COSMIC	SPSMAVPSP	DEG_COP1_1	0.5556
p.T997N	JAR	placenta	COSMIC	SPSMAVPSP	DEG_COP1_1	0.7055

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UU0	B-cell CLL/lymphoma 9-like protein	DEG_COP1_1	997:1005	SPSMAVPSP	COP1	0.9893	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons