DegronMD

Uniprot ID: Q86UU0

Source protein: B-cell CLL/lymphoma 9-like protein

Source gene: BCL9L

Class: DEG_SCF_FBW7_1

Location: 1176:1183

E3 ligase: FBXW7

DEGRON score: 0.9865

ASA_SCORE: 86.975

COIL: 0.9614

CONS_SCORE: 0.6641

DSS_SCORE: 0.7282

HELIX: 0.0154

FCONS_SCORE: 1.2871

RIG_SCORE: 0.5511

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1171L	DO233888	GACA	ICGC	PSPTPLGS	DEG_SCF_FBW7_1	0.1944
p.P1172T	DO229009	LICA	ICGC	PSPTPLGS	DEG_SCF_FBW7_1	0.2222
p.P1178L	DO222662	MELA	ICGC	PSPTPLGS	DEG_SCF_FBW7_1	0.6471
p.M1174V	DO228741	PRAD	ICGC	PSPTPLGS	DEG_SCF_FBW7_1	0.2778
p.T1179P	DO229253	THCA	ICGC	PSPTPLGS	DEG_SCF_FBW7_1	0.7031
p.T1179P	DO229245	THCA	ICGC	PSPTPLGS	DEG_SCF_FBW7_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UU0	B-cell CLL/lymphoma 9-like protein	DEG_SCF_FBW7_1	1176:1183	PSPTPLGS	FBXW7	0.9865	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons