DegronMD - Q8N1I0(DOCK4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1908Q	TCGA-2L-AAQJ	PAAD	TCGA	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.1944
p.K1898N	TCGA-BB-4223	HNSC	TCGA	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.2778
p.R1908W	TCGA-BR-8078	STAD	TCGA	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.1944
p.R1912C	TCGA-CV-7425	HNSC	TCGA	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.0833
p.P1913L	TCGA-DA-A1I7	SKCM	TCGA	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.0556
p.V1905I	TCGA-DF-A2KZ	UCEC	TCGA	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.2778
p.L1910V	TCGA-DW-7842	KIRP	TCGA	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.1389
p.P1902S	TCGA-FR-A3YO	SKCM	TCGA	PPPY	ITCH	1900:1903	Mutation altering degron motif	0.5641
p.P1902S	TCGA-YG-AA3N	SKCM	TCGA	PPPY	ITCH	1900:1903	Mutation altering degron motif	0.5641
p.Y1906F	TCGA-VQ-A8PH	STAD	TCGA	PPPY	ITCH	1900:1903	Mutation blocking phosphorylation signal	0.6944
p.Y1906C	TCGA-VS-A9UV	CESC	TCGA	PPPY	ITCH	1900:1903	Mutation blocking phosphorylation signal	0.6944
p.P1902L	TCGA-YG-AA3N	SKCM	TCGA	PPPY	ITCH	1900:1903	Mutation altering degron motif	0.6471
p.R1912L	SIDM02059	Colorectal Carcinoma	GDSC	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.0833
p.V1893M	SIDM00111	Glioma	GDSC	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.1389
p.V1893M	U251	central nervous system	COSMIC	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.1389
p.E1890G	ACH-000008	Skin Cancer	CCLE	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.0556
p.E1890G	ACH-000219	Skin Cancer	CCLE	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.0556
p.E1890G	ACH-000356	Gastric Cancer	CCLE	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.0556
p.E1890G	ACH-000401	Skin Cancer	CCLE	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.0556
p.E1890G	ACH-000431	Lung Cancer	CCLE	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.0556
p.E1890G	ACH-000465	Skin Cancer	CCLE	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.0556
p.E1890G	ACH-000491	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.0556
p.E1890G	ACH-000881	Skin Cancer	CCLE	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.0556
p.E1890G	ACH-000971	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.0556
p.E1890G	ACH-000987	Skin Cancer	CCLE	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.0556
p.E1890G	ACH-002120	Skin Cancer	CCLE	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.0556
p.E1890G	ACH-002173	Lung Cancer	CCLE	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.0556
p.R1911Q	ACH-000918	Leukemia	CCLE	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.1111
p.R1911Q	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.1111
p.R1911W	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.1111
p.R1911W	SNU-175	large intestine	COSMIC	PPPY	ITCH	1900:1903	Mutation rewiring degron network	0.1111

Kaplan plot for DOCK4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DOCK4

UniProt ID: Q8N1I0

Entrez ID: 9732

Protein name: Dedicator of cytokinesis protein 4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DOCK4 in