DegronMD

Uniprot ID: Q8N1I0

Source protein: Dedicator of cytokinesis protein 4

Source gene: DOCK4

Class: ITCH

Location: 1900:1903

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9993

ASA_SCORE: 67.075

COIL: 0.949

CONS_SCORE: 0.225

DSS_SCORE: 0.5678

HELIX: 0.0282

FCONS_SCORE: 1.0202

RIG_SCORE: 0.6521

Degron related mutations and impact score

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y1906F	TCGA-VQ-A8PH	STAD	TCGA	PPPY	ITCH	0.6944
p.Y1906C	TCGA-VS-A9UV	CESC	TCGA	PPPY	ITCH	0.6944
p.P1902L	TCGA-YG-AA3N	SKCM	TCGA	PPPY	ITCH	0.6471
p.P1902S	TCGA-FR-A3YO	SKCM	TCGA	PPPY	ITCH	0.5641
p.P1902S	TCGA-YG-AA3N	SKCM	TCGA	PPPY	ITCH	0.5641
p.K1898N	TCGA-BB-4223	HNSC	TCGA	PPPY	ITCH	0.2778
p.V1905I	TCGA-DF-A2KZ	UCEC	TCGA	PPPY	ITCH	0.2778
p.R1908Q	TCGA-2L-AAQJ	PAAD	TCGA	PPPY	ITCH	0.1944
p.R1908W	TCGA-BR-8078	STAD	TCGA	PPPY	ITCH	0.1944
p.L1910V	TCGA-DW-7842	KIRP	TCGA	PPPY	ITCH	0.1389
p.V1893M	SIDM00111	Glioma	GDSC	PPPY	ITCH	0.1389
p.V1893M	U251	central_nervous_system	COSMIC	PPPY	ITCH	0.1389
p.R1911Q	ACH-000918	Leukemia	CCLE	PPPY	ITCH	0.1111
p.R1911Q	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	PPPY	ITCH	0.1111
p.R1911W	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PPPY	ITCH	0.1111
p.R1911W	SNU-175	large_intestine	COSMIC	PPPY	ITCH	0.1111
p.R1912C	TCGA-CV-7425	HNSC	TCGA	PPPY	ITCH	0.0833
p.R1912L	SIDM02059	Colorectal Carcinoma	GDSC	PPPY	ITCH	0.0833
p.P1913L	TCGA-DA-A1I7	SKCM	TCGA	PPPY	ITCH	0.0556
p.E1890G	ACH-000008	Skin Cancer	CCLE	PPPY	ITCH	0.0556
p.E1890G	ACH-000219	Skin Cancer	CCLE	PPPY	ITCH	0.0556
p.E1890G	ACH-000356	Gastric Cancer	CCLE	PPPY	ITCH	0.0556
p.E1890G	ACH-000401	Skin Cancer	CCLE	PPPY	ITCH	0.0556
p.E1890G	ACH-000431	Lung Cancer	CCLE	PPPY	ITCH	0.0556
p.E1890G	ACH-000465	Skin Cancer	CCLE	PPPY	ITCH	0.0556

Showing 1 to 25 of 31 entries

Previous1 2Next

Drug responses associated with DOCK4 mutations

Show entries

Search:

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

Showing 0 to 0 of 0 entries

PreviousNext

All proteins holding degron of PPPY

Show entries

Search:

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96DV4	39S ribosomal protein L38, mitochondrial	ITCH	347:350	PPPY	ITCH,NEDD4	0.6466	More...
O15072	A disintegrin and metalloproteinase with thrombospondin motifs 3	ITCH	1058:1061	PPPY	ITCH,NEDD4	0.9797	More...
Q13625	Apoptosis-stimulating of p53 protein 2	ITCH	871:874	PPPY	ITCH,NEDD4	0.9885	More...
P54259	Atrophin-1	ITCH	445:448	PPPY	ITCH,NEDD4	0.973	More...
P54259	Atrophin-1	ITCH	636:639	PPPY	ITCH,NEDD4	0.9909	More...
Q8WXX7	Autism susceptibility gene 2 protein	ITCH	516:519	PPPY	ITCH,NEDD4	0.9979	More...
O00512	B-cell CLL/lymphoma 9 protein	ITCH	515:518	PPPY	ITCH,NEDD4	0.9973	More...
Q86UU0	B-cell CLL/lymphoma 9-like protein	ITCH	561:564	PPPY	ITCH,NEDD4	0.9923	More...
O95395	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3	ITCH	285:288	PPPY	ITCH,NEDD4	0.5532	More...
O95415	Brain protein I3	ITCH	39:42	PPPY	ITCH,NEDD4	0.9496	More...
Q15018	BRISC complex subunit Abraxas 2	ITCH	305:308	PPPY	ITCH,NEDD4	0.9939	More...
Q9P203	BTB/POZ domain-containing protein 7	ITCH	762:765	PPPY	ITCH,NEDD4	0.9575	More...
Q9Y6W3	Calpain-7	ITCH	624:627	PPPY	ITCH,NEDD4	0.5393	More...
Q8WXE0	Caskin-2	ITCH	751:754	PPPY	ITCH,NEDD4	0.6879	More...
Q9H305	Cell death-inducing p53-target protein 1	ITCH	6:9	PPPY	ITCH,NEDD4	0.9945	More...
Q9H305	Cell death-inducing p53-target protein 1	ITCH	51:54	PPPY	ITCH,NEDD4	0.9943	More...
Q16630	Cleavage and polyadenylation specificity factor subunit 6	ITCH	387:390	PPPY	ITCH,NEDD4	0.9919	More...
Q8WXI2	Connector enhancer of kinase suppressor of ras 2	ITCH	704:707	PPPY	ITCH,NEDD4	0.9478	More...
Q86YQ8	Copine-8	ITCH	550:553	PPPY	ITCH,NEDD4	0.743	More...
Q6UUV7	CREB-regulated transcription coactivator 3	ITCH	445:448	PPPY	ITCH,NEDD4	0.998	More...
Q96J86	Cysteine and tyrosine-rich protein 1	ITCH	113:116	PPPY	ITCH,NEDD4	0.9396	More...
Q96J86	Cysteine and tyrosine-rich protein 1	ITCH	129:132	PPPY	ITCH,NEDD4	0.9428	More...
Q96J86	Cysteine and tyrosine-rich protein 1	ITCH	145:148	PPPY	ITCH,NEDD4	0.9794	More...
Q9H1C7	Cysteine-rich and transmembrane domain-containing protein 1	ITCH	6:9	PPPY	ITCH,NEDD4	0.9391	More...
Q9BTC0	Death-inducer obliterator 1	ITCH	1817:1820	PPPY	ITCH,NEDD4	0.9967	More...

Showing 1 to 25 of 180 entries

Previous1 2 3 4 5…8Next

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPPY

Degron related mutations and impact score

Drug responses associated with DOCK4 mutations

All proteins holding degron of PPPY