DegronMD - Q92922(SMARCC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E198D	TCGA-06-5416	GBM	TCGA	PYSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.0556
p.E198D	DO222884	COCA	ICGC	PYSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.0556
p.E198D	DO10880	GBM	ICGC	PYSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.0556
p.P208Q	TCGA-53-7626	LUAD	TCGA	PYSSS	DEG_SPOP_SBC_1	208:212	Mutation altering degron motif	0.7035
p.P208Q	DO23774	LUAD	ICGC	PYSSS	DEG_SPOP_SBC_1	208:212	Mutation altering degron motif	0.7035
p.E198Q	TCGA-56-A49D	LUSC	TCGA	PYSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.0556
p.E198Q	DO45475	LUSC	ICGC	PYSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.0556
p.K392N	TCGA-BR-8680	STAD	TCGA	DSENTPVK	DEG_SCF_SKP2-CKS1_1	394:401	Mutation rewiring degron network	0.2778
p.K392N	DO47769	STAD	ICGC	DSENTPVK	DEG_SCF_SKP2-CKS1_1	394:401	Mutation rewiring degron network	0.2778
p.D394Y	TCGA-BS-A0UV	UCEC	TCGA	DSENTPVK	DEG_SCF_SKP2-CKS1_1	394:401	Mutation altering degron motif	0.6214
p.D394Y	DO42793	UCEC	ICGC	DSENTPVK	DEG_SCF_SKP2-CKS1_1	394:401	Mutation altering degron motif	0.6214
p.P996S	TCGA-CK-4951	COAD	TCGA	PPPY	ITCH	996:999	Mutation altering degron motif	0.6752
p.P996S	DO10582	COAD	ICGC	PPPY	ITCH	996:999	Mutation altering degron motif	0.6752
p.V400G	TCGA-D9-A6EC	SKCM	TCGA	DSENTPVK	DEG_SCF_SKP2-CKS1_1	394:401	Mutation altering degron motif	0.6421
p.V400G	DO232761	PBCA	ICGC	DSENTPVK	DEG_SCF_SKP2-CKS1_1	394:401	Mutation altering degron motif	0.6421
p.V400G	DO50291	SKCM	ICGC	DSENTPVK	DEG_SCF_SKP2-CKS1_1	394:401	Mutation altering degron motif	0.6421
p.E410K	TCGA-DK-AA71	BLCA	TCGA	DSENTPVK	DEG_SCF_SKP2-CKS1_1	394:401	Mutation rewiring degron network	0.0833
p.P997L	TCGA-FW-A3R5	SKCM	TCGA	PPPY	ITCH	996:999	Mutation altering degron motif	0.7582
p.P997L	DO37406	SKCM	ICGC	PPPY	ITCH	996:999	Mutation altering degron motif	0.7582
p.D215N	DO228046	EOPC	ICGC	PYSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.25
p.V400L	DO231987	LICA	ICGC	DSENTPVK	DEG_SCF_SKP2-CKS1_1	394:401	Mutation altering degron motif	0.5654
p.P1000T	DO229035	LICA	ICGC	PPPY	ITCH	996:999	Mutation rewiring degron network	0.3056
p.P998F	DO220881	MELA	ICGC	PPPY	ITCH	996:999	Mutation altering degron motif	0.6786
p.P998S	DO220881	MELA	ICGC	PPPY	ITCH	996:999	Mutation altering degron motif	0.5641
p.P998L	DO220881	MELA	ICGC	PPPY	ITCH	996:999	Mutation altering degron motif	0.6471
p.S211F	DO222536	MELA	ICGC	PYSSS	DEG_SPOP_SBC_1	208:212	Mutation altering degron motif	0.7982
p.P992S	DO232761	PBCA	ICGC	PPPY	ITCH	996:999	Mutation rewiring degron network	0.2222
p.M991I	DO229264	THCA	ICGC	PPPY	ITCH	996:999	Mutation rewiring degron network	0.1944
p.L385I	DO229221	THCA	ICGC	DSENTPVK	DEG_SCF_SKP2-CKS1_1	394:401	Mutation rewiring degron network	0.0833
p.M990I	SIDM01218	Other Solid Cancers	GDSC	PPPY	ITCH	996:999	Mutation rewiring degron network	0.1667
p.M990I	ACH-001530	Endometrial/Uterine Cancer	CCLE	PPPY	ITCH	996:999	Mutation rewiring degron network	0.1667
p.M990I	JEG-3	placenta	COSMIC	PPPY	ITCH	996:999	Mutation rewiring degron network	0.1667
p.P221L	SIDM00449	B-Lymphoblastic Leukemia	GDSC	PYSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.0833
p.P221L	SIDM00596	Endometrial Carcinoma	GDSC	PYSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.0833
p.P221L	ACH-000922	Leukemia	CCLE	PYSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.0833
p.P221L	ACH-001517	Endometrial/Uterine Cancer	CCLE	PYSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.0833
p.P221L	HEC-1	endometrium	COSMIC	PYSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.0833
p.P221L	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	PYSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.0833

Kaplan plot for SMARCC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMARCC1

UniProt ID: Q92922

Entrez ID: 6599

Protein name: SWI/SNF complex subunit SMARCC1 (BRG1-associated factor 155) (BAF155) (SWI/SNF complex 155 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMARCC1 in