DegronMD

Uniprot ID: Q92922

Source protein: SWI/SNF complex subunit SMARCC1

Source gene: SMARCC1

Class: DEG_SCF_SKP2-CKS1_1

Location: 394:401

E3 ligase: SKP2,CSK1

DEGRON score: 0.9929

ASA_SCORE: 96.4375

COIL: 0.914

CONS_SCORE: 0.3329

DSS_SCORE: 0.5825

HELIX: 0.0576

FCONS_SCORE: 1.0694

RIG_SCORE: 0.6731

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V400G	TCGA-D9-A6EC	SKCM	TCGA	DSENTPVK	DEG_SCF_SKP2-CKS1_1	0.6421
p.V400G	DO232761	PBCA	ICGC	DSENTPVK	DEG_SCF_SKP2-CKS1_1	0.6421
p.V400G	DO50291	SKCM	ICGC	DSENTPVK	DEG_SCF_SKP2-CKS1_1	0.6421
p.D394Y	TCGA-BS-A0UV	UCEC	TCGA	DSENTPVK	DEG_SCF_SKP2-CKS1_1	0.6214
p.D394Y	DO42793	UCEC	ICGC	DSENTPVK	DEG_SCF_SKP2-CKS1_1	0.6214
p.V400L	DO231987	LICA	ICGC	DSENTPVK	DEG_SCF_SKP2-CKS1_1	0.5654
p.K392N	TCGA-BR-8680	STAD	TCGA	DSENTPVK	DEG_SCF_SKP2-CKS1_1	0.2778
p.K392N	DO47769	STAD	ICGC	DSENTPVK	DEG_SCF_SKP2-CKS1_1	0.2778
p.E410K	TCGA-DK-AA71	BLCA	TCGA	DSENTPVK	DEG_SCF_SKP2-CKS1_1	0.0833
p.L385I	DO229221	THCA	ICGC	DSENTPVK	DEG_SCF_SKP2-CKS1_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92922	SWI/SNF complex subunit SMARCC1	DEG_SCF_SKP2-CKS1_1	394:401	DSENTPVK	SKP2,CSK1	0.9929	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons