DegronMD - Q9BTC0(DIDO1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G85S	TCGA-06-0877	GBM	TCGA	DSGEPTS	DEG_SCF_TRCP1_1	95:101	Mutation rewiring degron network	0.0556
p.G85S	DO13108	GBM	ICGC	DSGEPTS	DEG_SCF_TRCP1_1	95:101	Mutation rewiring degron network	0.0556
p.R2040H	TCGA-41-3393	GBM	TCGA	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.0833
p.R2040H	DO12646	GBM	ICGC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.0833
p.R2040H	SIDM01049	Non-Cancerous	GDSC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.0833
p.R2040H	ACH-000038	Lymphoma	CCLE	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.0833
p.R2040H	EHEB	haematopoietic and lymphoid tissue	COSMIC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.0833
p.A104S	TCGA-44-5644	LUAD	TCGA	DSGEPTS	DEG_SCF_TRCP1_1	95:101	Mutation rewiring degron network	0.25
p.A104S	DO25153	LUAD	ICGC	DSGEPTS	DEG_SCF_TRCP1_1	95:101	Mutation rewiring degron network	0.25
p.E772Q	TCGA-55-8092	LUAD	TCGA	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.0556
p.E772Q	DO26220	LUAD	ICGC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.0556
p.R2040C	TCGA-5M-AAT6	COAD	TCGA	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.0833
p.R2040C	DO223703	COAD	ICGC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.0833
p.T109I	TCGA-78-7220	LUAD	TCGA	DSGEPTS	DEG_SCF_TRCP1_1	95:101	Mutation blocking phosphorylation signal	0.5556
p.T109I	DO24409	LUAD	ICGC	DSGEPTS	DEG_SCF_TRCP1_1	95:101	Mutation blocking phosphorylation signal	0.5556
p.P1258A	TCGA-83-5908	LUAD	TCGA	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation altering degron motif	0.6392
p.P1258A	DO23572	LUAD	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation altering degron motif	0.6392
p.E2060D	TCGA-86-8585	LUAD	TCGA	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.1389
p.E2060D	DO24850	LUAD	ICGC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.1389
p.S1829F	TCGA-86-A4JF	LUAD	TCGA	PPPY	ITCH	1817:1820	Mutation rewiring degron network	0.0833
p.S1829F	DO45317	LUAD	ICGC	PPPY	ITCH	1817:1820	Mutation rewiring degron network	0.0833
p.S1312L	TCGA-98-A538	LUSC	TCGA	AASST	DEG_SPOP_SBC_1	1299:1303	Mutation blocking phosphorylation signal	0.5278
p.S1312L	DO219177	LUSC	ICGC	AASST	DEG_SPOP_SBC_1	1299:1303	Mutation blocking phosphorylation signal	0.5278
p.P1262A	TCGA-A8-A09M	BRCA	TCGA	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation rewiring degron network	0.2778
p.P1262A	TCGA-A8-A09M	BRCA	TCGA	AVSTT	DEG_SPOP_SBC_1	1252:1256	Mutation rewiring degron network	0.1667
p.P1262A	DO3852	BRCA	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation rewiring degron network	0.2778
p.P1262A	DO3852	BRCA	ICGC	AVSTT	DEG_SPOP_SBC_1	1252:1256	Mutation rewiring degron network	0.1667
p.P1313L	TCGA-AA-3713	COAD	TCGA	AASST	DEG_SPOP_SBC_1	1299:1303	Mutation rewiring degron network	0.0556
p.P1313L	TCGA-FI-A2D6	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	1299:1303	Mutation rewiring degron network	0.0556
p.P1313L	DO8400	COAD	ICGC	AASST	DEG_SPOP_SBC_1	1299:1303	Mutation rewiring degron network	0.0556
p.P1313L	DO43867	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	1299:1303	Mutation rewiring degron network	0.0556
p.E788K	TCGA-AC-A23H	BRCA	TCGA	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation altering degron motif	0.7022
p.E788K	TCGA-IR-A3LA	CESC	TCGA	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation altering degron motif	0.7022
p.E788K	DO2401	BRCA	ICGC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation altering degron motif	0.7022
p.E788K	DO44377	CESC	ICGC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation altering degron motif	0.7022
p.E772K	TCGA-AC-A23H	BRCA	TCGA	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.0556
p.E772K	DO2401	BRCA	ICGC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.0556
p.E772K	SIDM00745	Non-Small Cell Lung Carcinoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.0556
p.E772K	ACH-000035	Lung Cancer	CCLE	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.0556
p.E772K	NCI-H1650	lung	COSMIC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.0556
p.R773S	TCGA-AP-A051	UCEC	TCGA	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.0833
p.R773S	DO42673	UCEC	ICGC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.0833
p.C1247Y	TCGA-AX-A2HD	UCEC	TCGA	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation rewiring degron network	0.1667
p.C1247Y	TCGA-AX-A2HD	UCEC	TCGA	AVSTT	DEG_SPOP_SBC_1	1252:1256	Mutation rewiring degron network	0.1944
p.C1247Y	DO42608	UCEC	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation rewiring degron network	0.1667
p.C1247Y	DO42608	UCEC	ICGC	AVSTT	DEG_SPOP_SBC_1	1252:1256	Mutation rewiring degron network	0.1944
p.P1808L	TCGA-B2-4102	KIRC	TCGA	PPPY	ITCH	1817:1820	Mutation rewiring degron network	0.0833
p.P1808L	DO18839	KIRC	ICGC	PPPY	ITCH	1817:1820	Mutation rewiring degron network	0.0833
p.P1262L	TCGA-B7-5816	STAD	TCGA	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation rewiring degron network	0.2778
p.P1262L	TCGA-B7-5816	STAD	TCGA	AVSTT	DEG_SPOP_SBC_1	1252:1256	Mutation rewiring degron network	0.1667
p.P1262L	DO38599	STAD	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation rewiring degron network	0.2778
p.P1262L	DO38599	STAD	ICGC	AVSTT	DEG_SPOP_SBC_1	1252:1256	Mutation rewiring degron network	0.1667
p.S777F	TCGA-BF-AAP1	SKCM	TCGA	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.1944
p.S777F	DO219464	SKCM	ICGC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.1944
p.S1305L	TCGA-BR-8680	STAD	TCGA	AASST	DEG_SPOP_SBC_1	1299:1303	Mutation rewiring degron network	0.2778
p.S1305L	TCGA-EE-A29V	SKCM	TCGA	AASST	DEG_SPOP_SBC_1	1299:1303	Mutation rewiring degron network	0.2778
p.S1305L	TCGA-F5-6814	READ	TCGA	AASST	DEG_SPOP_SBC_1	1299:1303	Mutation rewiring degron network	0.2778
p.S1305L	DO36556	READ	ICGC	AASST	DEG_SPOP_SBC_1	1299:1303	Mutation rewiring degron network	0.2778
p.S1305L	DO38006	SKCM	ICGC	AASST	DEG_SPOP_SBC_1	1299:1303	Mutation rewiring degron network	0.2778
p.S1305L	DO47769	STAD	ICGC	AASST	DEG_SPOP_SBC_1	1299:1303	Mutation rewiring degron network	0.2778
p.G965C	TCGA-CG-5721	STAD	TCGA	APSSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.1667
p.G965C	DO38192	STAD	ICGC	APSSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.1667
p.P1828L	TCGA-CR-7388	HNSC	TCGA	PPPY	ITCH	1817:1820	Mutation rewiring degron network	0.1111
p.P1828L	DO14284	HNSC	ICGC	PPPY	ITCH	1817:1820	Mutation rewiring degron network	0.1111
p.S2051F	TCGA-D3-A5GN	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation altering degron motif	0.7982
p.S2051F	DO47317	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation altering degron motif	0.7982
p.A2054V	TCGA-DF-A2KU	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.3056
p.A2054V	TCGA-FP-A4BE	STAD	TCGA	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.3056
p.A2054V	TCGA-HU-A4H3	STAD	TCGA	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.3056
p.A2054V	DO48016	STAD	ICGC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.3056
p.A2054V	DO47903	STAD	ICGC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.3056
p.A2054V	DO223286	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.3056
p.A2054V	SIDM00683	Prostate Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.3056
p.A2054V	SIDM00216	Colorectal Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.3056
p.A2054V	SIDM00837	Colorectal Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.3056
p.A2054V	ACH-000958	Colon/Colorectal Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.3056
p.A2054V	ACH-000977	lymph node	CCLE	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.3056
p.A2054V	ACH-000989	Colon/Colorectal Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.3056
p.A2054V	SW48	large intestine	COSMIC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.3056
p.A2054V	LNCaP-Clone-FGC	prostate	COSMIC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.3056
p.A2054V	SNU-175	large intestine	COSMIC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.3056
p.R1824T	TCGA-DK-A1A6	BLCA	TCGA	PPPY	ITCH	1817:1820	Mutation rewiring degron network	0.2222
p.R1824T	DO472	BLCA	ICGC	PPPY	ITCH	1817:1820	Mutation rewiring degron network	0.2222
p.G1259V	TCGA-DK-A3IK	BLCA	TCGA	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation altering degron motif	0.6421
p.G1259V	DO454	BLCA	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation altering degron motif	0.6421
p.E2043K	TCGA-EA-A439	CESC	TCGA	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.1667
p.E2043K	DO44297	CESC	ICGC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.1667
p.P1264L	TCGA-EB-A41A	SKCM	TCGA	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation rewiring degron network	0.2222
p.P1264L	TCGA-EB-A41A	SKCM	TCGA	AVSTT	DEG_SPOP_SBC_1	1252:1256	Mutation rewiring degron network	0.1111
p.P1264L	TCGA-KQ-A41N	BLCA	TCGA	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation rewiring degron network	0.2222
p.P1264L	TCGA-KQ-A41N	BLCA	TCGA	AVSTT	DEG_SPOP_SBC_1	1252:1256	Mutation rewiring degron network	0.1111
p.P1264L	DO223588	BLCA	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation rewiring degron network	0.2222
p.P1264L	DO223588	BLCA	ICGC	AVSTT	DEG_SPOP_SBC_1	1252:1256	Mutation rewiring degron network	0.1111
p.P1264L	DO37429	SKCM	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation rewiring degron network	0.2222
p.P1264L	DO37429	SKCM	ICGC	AVSTT	DEG_SPOP_SBC_1	1252:1256	Mutation rewiring degron network	0.1111
p.P2059L	TCGA-EE-A183	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.1667
p.P2059L	DO37715	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.1667
p.P2059L	SIDM00695	Melanoma	GDSC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.1667
p.P2059L	ACH-000322	Skin Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.1667
p.P2059L	ACH-002458	Skin Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.1667
p.P2059L	ACH-002459	Skin Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.1667
p.P2059L	ACH-002460	Skin Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.1667
p.P2059L	HT-144	skin	COSMIC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.1667
p.P972S	TCGA-EE-A2GC	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	971:975	Mutation altering degron motif	0.5641
p.P972S	DO37839	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	971:975	Mutation altering degron motif	0.5641
p.P794S	TCGA-EE-A2GO	SKCM	TCGA	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.1667
p.P794S	DO37823	SKCM	ICGC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.1667
p.P1268S	TCGA-EE-A3JA	SKCM	TCGA	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation rewiring degron network	0.1111
p.P1268S	DO47625	SKCM	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation rewiring degron network	0.1111
p.E2060K	TCGA-ER-A42L	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.1389
p.E2060K	DO223910	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.1389
p.E2060K	SIDM00679	Cervical Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.1389
p.E2060K	ACH-001525	Cervical Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.1389
p.E2060K	HT-3	cervix	COSMIC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.1389
p.S1809Y	TCGA-G2-A2EC	BLCA	TCGA	PPPY	ITCH	1817:1820	Mutation rewiring degron network	0.1111
p.S1809Y	DO651	BLCA	ICGC	PPPY	ITCH	1817:1820	Mutation rewiring degron network	0.1111
p.P1261S	TCGA-G4-6304	COAD	TCGA	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation rewiring degron network	0.3056
p.P1261S	TCGA-G4-6304	COAD	TCGA	AVSTT	DEG_SPOP_SBC_1	1252:1256	Mutation rewiring degron network	0.1944
p.P1261S	DO10639	COAD	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation rewiring degron network	0.3056
p.P1261S	DO10639	COAD	ICGC	AVSTT	DEG_SPOP_SBC_1	1252:1256	Mutation rewiring degron network	0.1944
p.P1261S	DO233168	GACA	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation rewiring degron network	0.3056
p.P1261S	DO233168	GACA	ICGC	AVSTT	DEG_SPOP_SBC_1	1252:1256	Mutation rewiring degron network	0.1944
p.S1260L	TCGA-GN-A266	SKCM	TCGA	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation altering degron motif	0.8778
p.S1260L	DO37432	SKCM	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation altering degron motif	0.8778
p.T792K	TCGA-GS-A9TY	DLBC	TCGA	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.2222
p.T792K	DO219917	DLBC	ICGC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.2222
p.A1304V	TCGA-IP-7968	STAD	TCGA	AASST	DEG_SPOP_SBC_1	1299:1303	Mutation rewiring degron network	0.3056
p.A1304V	DO38183	STAD	ICGC	AASST	DEG_SPOP_SBC_1	1299:1303	Mutation rewiring degron network	0.3056
p.D967Y	TCGA-KN-8427	KICH	TCGA	APSSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.2222
p.D967Y	DO220479	KICH	ICGC	APSSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.2222
p.A1249G	TCGA-KO-8408	KICH	TCGA	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation rewiring degron network	0.2222
p.A1249G	TCGA-KO-8408	KICH	TCGA	AVSTT	DEG_SPOP_SBC_1	1252:1256	Mutation rewiring degron network	0.25
p.A1249G	DO220562	KICH	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation rewiring degron network	0.2222
p.A1249G	DO220562	KICH	ICGC	AVSTT	DEG_SPOP_SBC_1	1252:1256	Mutation rewiring degron network	0.25
p.A2049V	TCGA-S4-A8RM	PAAD	TCGA	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation altering degron motif	0.5825
p.A2049V	DO50266	PAAD	ICGC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation altering degron motif	0.5825
p.A2049V	SIDM02049	Pancreatic Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation altering degron motif	0.5825
p.R1824K	TCGA-SY-A9G5	BLCA	TCGA	PPPY	ITCH	1817:1820	Mutation rewiring degron network	0.2222
p.R1824K	DO51906	BLCA	ICGC	PPPY	ITCH	1817:1820	Mutation rewiring degron network	0.2222
p.S92C	TCGA-T3-A92M	HNSC	TCGA	DSGEPTS	DEG_SCF_TRCP1_1	95:101	Mutation blocking phosphorylation signal	0.6944
p.S92C	DO223269	HNSC	ICGC	DSGEPTS	DEG_SCF_TRCP1_1	95:101	Mutation blocking phosphorylation signal	0.6944
p.E108K	TCGA-W3-AA1R	SKCM	TCGA	DSGEPTS	DEG_SCF_TRCP1_1	95:101	Mutation rewiring degron network	0.1389
p.E108K	DO51275	SKCM	ICGC	DSGEPTS	DEG_SCF_TRCP1_1	95:101	Mutation rewiring degron network	0.1389
p.T1298M	TCGA-Z5-AAPL	PAAD	TCGA	AASST	DEG_SPOP_SBC_1	1299:1303	Mutation rewiring degron network	0.3056
p.T1298M	DO218975	PAAD	ICGC	AASST	DEG_SPOP_SBC_1	1299:1303	Mutation rewiring degron network	0.3056
p.P1270L	DO48421	BLCA	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation rewiring degron network	0.0556
p.V778L	DO225280	BRCA	ICGC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.2222
p.R776K	DO1158	BRCA	ICGC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.1667
p.E772D	DO222594	ESCA	ICGC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.0556
p.Q2057K	DO228974	LICA	ICGC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.2222
p.S1254R	DO228976	LICA	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation altering degron motif	0.7427
p.S1254R	DO228976	LICA	ICGC	AVSTT	DEG_SPOP_SBC_1	1252:1256	Mutation altering degron motif	0.8538
p.T1310K	DO228985	LICA	ICGC	AASST	DEG_SPOP_SBC_1	1299:1303	Mutation blocking phosphorylation signal	0.5833
p.F1811L	DO229029	LICA	ICGC	PPPY	ITCH	1817:1820	Mutation rewiring degron network	0.1667
p.P103H	DO229022	LICA	ICGC	DSGEPTS	DEG_SCF_TRCP1_1	95:101	Mutation rewiring degron network	0.2778
p.A775E	DO229038	LICA	ICGC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.1389
p.P1270Q	DO229041	LICA	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation rewiring degron network	0.0556
p.T1256A	DO231792	LINC	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation altering degron motif	0.825
p.T1256A	DO231792	LINC	ICGC	AVSTT	DEG_SPOP_SBC_1	1252:1256	Mutation altering degron motif	0.825
p.S973G	DO45077	LINC	ICGC	APSSS	DEG_SPOP_SBC_1	971:975	Mutation altering degron motif	0.6993
p.P2046S	DO220886	MELA	ICGC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.25
p.P1819F	DO222644	MELA	ICGC	PPPY	ITCH	1817:1820	Mutation altering degron motif	0.6786
p.T100M	DO229253	THCA	ICGC	DSGEPTS	DEG_SCF_TRCP1_1	95:101	Mutation altering degron motif	0.6312
p.A775V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.1389
p.A775V	ACH-000995	Leukemia	CCLE	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.1389
p.A775V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.1389
p.N787S	SIDM01151	Hepatocellular Carcinoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation altering degron motif	0.5958
p.N787S	SIDM00535	Chondrosarcoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation altering degron motif	0.5958
p.N787S	SIDM00555	Glioblastoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation altering degron motif	0.5958
p.N787S	SIDM00193	Colorectal Carcinoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation altering degron motif	0.5958
p.N787S	SIDM01196	Hepatocellular Carcinoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation altering degron motif	0.5958
p.N787S	SIDM00489	Oral Cavity Carcinoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation altering degron motif	0.5958
p.N787S	SIDM00245	Small Cell Lung Carcinoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation altering degron motif	0.5958
p.N787S	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation altering degron motif	0.5958
p.N787S	SIDM01336	Glioblastoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation altering degron motif	0.5958
p.N787S	SIDM00497	Colorectal Carcinoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation altering degron motif	0.5958
p.P99L	SIDM01175	Other Sarcomas	GDSC	DSGEPTS	DEG_SCF_TRCP1_1	95:101	Mutation altering degron motif	0.6471
p.P99L	ACH-002309	Sarcoma	CCLE	DSGEPTS	DEG_SCF_TRCP1_1	95:101	Mutation altering degron motif	0.6471
p.P99L	SW684	soft tissue	COSMIC	DSGEPTS	DEG_SCF_TRCP1_1	95:101	Mutation altering degron motif	0.6471
p.A1251T	SIDM00789	Colorectal Carcinoma	GDSC	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation rewiring degron network	0.2778
p.A1251T	SIDM00789	Colorectal Carcinoma	GDSC	AVSTT	DEG_SPOP_SBC_1	1252:1256	Mutation rewiring degron network	0.3056
p.A1251T	ACH-000997	Colon/Colorectal Cancer	CCLE	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation rewiring degron network	0.2778
p.A1251T	ACH-000997	Colon/Colorectal Cancer	CCLE	AVSTT	DEG_SPOP_SBC_1	1252:1256	Mutation rewiring degron network	0.3056
p.A1251T	ACH-001061	Colon/Colorectal Cancer	CCLE	VSTTPPGS	DEG_SCF_FBW7_1	1253:1260	Mutation rewiring degron network	0.2778
p.A1251T	ACH-001061	Colon/Colorectal Cancer	CCLE	AVSTT	DEG_SPOP_SBC_1	1252:1256	Mutation rewiring degron network	0.3056
p.G1825C	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	1817:1820	Mutation rewiring degron network	0.1944
p.G1825C	ACH-002256	Leukemia	CCLE	PPPY	ITCH	1817:1820	Mutation rewiring degron network	0.1944
p.G1825C	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	1817:1820	Mutation rewiring degron network	0.1944
p.G965D	SIDM01007	T-Lymphoblastic Leukemia	GDSC	APSSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.1667
p.G965D	ACH-002256	Leukemia	CCLE	APSSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.1667
p.G965D	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	APSSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.1667
p.M89I	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSGEPTS	DEG_SCF_TRCP1_1	95:101	Mutation rewiring degron network	0.1667
p.M89I	ACH-002256	Leukemia	CCLE	DSGEPTS	DEG_SCF_TRCP1_1	95:101	Mutation rewiring degron network	0.1667
p.M89I	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DSGEPTS	DEG_SCF_TRCP1_1	95:101	Mutation rewiring degron network	0.1667
p.A793T	SIDM00282	Colorectal Carcinoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.1944
p.A793T	ACH-000998	Colon/Colorectal Cancer	CCLE	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.1944
p.A793T	CW-2	large intestine	COSMIC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.1944
p.A978V	SIDM00290	Gastric Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.25
p.A978V	ACH-000847	Gastric Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.25
p.A978V	HGC-27	stomach	COSMIC	APSSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.25
p.P972L	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	971:975	Mutation altering degron motif	0.6471
p.P972L	ACH-000945	Lung Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	971:975	Mutation altering degron motif	0.6471
p.P972L	NCI-H650	lung	COSMIC	APSSS	DEG_SPOP_SBC_1	971:975	Mutation altering degron motif	0.6471
p.V961I	SIDM01051	Ovarian Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.0556
p.S1809F	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	1817:1820	Mutation rewiring degron network	0.1111
p.S1809F	ACH-000904	Lung Cancer	CCLE	PPPY	ITCH	1817:1820	Mutation rewiring degron network	0.1111
p.S1809F	ACH-001362	Lung Cancer	CCLE	PPPY	ITCH	1817:1820	Mutation rewiring degron network	0.1111
p.S1809F	NCI-H1770	lung	COSMIC	PPPY	ITCH	1817:1820	Mutation rewiring degron network	0.1111
p.H786Y	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation altering degron motif	0.6118
p.H786Y	ACH-000873	Esophageal Cancer	CCLE	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation altering degron motif	0.6118
p.H786Y	KYSE-270	oesophagus	COSMIC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation altering degron motif	0.6118
p.A2044V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.1944
p.A2044V	ACH-001127	Leukemia	CCLE	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.1944
p.A2044V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	ALSSS	DEG_SPOP_SBC_1	2049:2053	Mutation rewiring degron network	0.1944
p.P103L	SIDM00503	Gastric Carcinoma	GDSC	DSGEPTS	DEG_SCF_TRCP1_1	95:101	Mutation rewiring degron network	0.2778
p.P103L	ACH-000633	Gastric Cancer	CCLE	DSGEPTS	DEG_SCF_TRCP1_1	95:101	Mutation rewiring degron network	0.2778
p.P103L	FU97	stomach	COSMIC	DSGEPTS	DEG_SCF_TRCP1_1	95:101	Mutation rewiring degron network	0.2778
p.S973R	SIDM00153	T-Lymphoblastic Leukemia	GDSC	APSSS	DEG_SPOP_SBC_1	971:975	Mutation altering degron motif	0.7427
p.S973R	ACH-000964	Leukemia	CCLE	APSSS	DEG_SPOP_SBC_1	971:975	Mutation altering degron motif	0.7427
p.G1825D	SIDM01570	Ovarian Carcinoma	GDSC	PPPY	ITCH	1817:1820	Mutation rewiring degron network	0.1944
p.G1825D	ACH-000324	Ovarian Cancer	CCLE	PPPY	ITCH	1817:1820	Mutation rewiring degron network	0.1944
p.R985H	SIDM01699	Chondrosarcoma	GDSC	APSSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.0556
p.A1290V	ACH-000998	Colon/Colorectal Cancer	CCLE	AASST	DEG_SPOP_SBC_1	1299:1303	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DIDO1

UniProt ID: Q9BTC0

Entrez ID: 11083

Protein name: Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DIDO1 in