DegronMD

Uniprot ID: Q9BTC0

Source protein: Death-inducer obliterator 1

Source gene: DIDO1

Class: DEG_SCF_TRCP1_1

Location: 95:101

E3 ligase: BTRC

DEGRON score: 0.9887

ASA_SCORE: 79.0571

COIL: 0.9191

CONS_SCORE: 0.3531

DSS_SCORE: 0.6981

HELIX: 0.062

FCONS_SCORE: 0.8638

RIG_SCORE: 0.5891

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G85S	TCGA-06-0877	GBM	TCGA	DSGEPTS	DEG_SCF_TRCP1_1	0.0556
p.G85S	DO13108	GBM	ICGC	DSGEPTS	DEG_SCF_TRCP1_1	0.0556
p.A104S	TCGA-44-5644	LUAD	TCGA	DSGEPTS	DEG_SCF_TRCP1_1	0.25
p.A104S	DO25153	LUAD	ICGC	DSGEPTS	DEG_SCF_TRCP1_1	0.25
p.T109I	TCGA-78-7220	LUAD	TCGA	DSGEPTS	DEG_SCF_TRCP1_1	0.5556
p.T109I	DO24409	LUAD	ICGC	DSGEPTS	DEG_SCF_TRCP1_1	0.5556
p.S92C	TCGA-T3-A92M	HNSC	TCGA	DSGEPTS	DEG_SCF_TRCP1_1	0.6944
p.S92C	DO223269	HNSC	ICGC	DSGEPTS	DEG_SCF_TRCP1_1	0.6944
p.E108K	TCGA-W3-AA1R	SKCM	TCGA	DSGEPTS	DEG_SCF_TRCP1_1	0.1389
p.E108K	DO51275	SKCM	ICGC	DSGEPTS	DEG_SCF_TRCP1_1	0.1389
p.P103H	DO229022	LICA	ICGC	DSGEPTS	DEG_SCF_TRCP1_1	0.2778
p.T100M	DO229253	THCA	ICGC	DSGEPTS	DEG_SCF_TRCP1_1	0.6312
p.P99L	SIDM01175	Other Sarcomas	GDSC	DSGEPTS	DEG_SCF_TRCP1_1	0.6471
p.P99L	ACH-002309	Sarcoma	CCLE	DSGEPTS	DEG_SCF_TRCP1_1	0.6471
p.P99L	SW684	soft_tissue	COSMIC	DSGEPTS	DEG_SCF_TRCP1_1	0.6471
p.M89I	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSGEPTS	DEG_SCF_TRCP1_1	0.1667
p.M89I	ACH-002256	Leukemia	CCLE	DSGEPTS	DEG_SCF_TRCP1_1	0.1667
p.M89I	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DSGEPTS	DEG_SCF_TRCP1_1	0.1667
p.P103L	SIDM00503	Gastric Carcinoma	GDSC	DSGEPTS	DEG_SCF_TRCP1_1	0.2778
p.P103L	ACH-000633	Gastric Cancer	CCLE	DSGEPTS	DEG_SCF_TRCP1_1	0.2778
p.P103L	FU97	stomach	COSMIC	DSGEPTS	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BTC0	Death-inducer obliterator 1	DEG_SCF_TRCP1_1	95:101	DSGEPTS	BTRC	0.9887	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons